Hydroxyapatite (HA) is a widely used biomaterial for implant thin films, largely recognized for its excellent capability to chemically bond to hard tissue inducing the osteogenesis without immune response from human tissues. Nowadays, intense research efforts are focused on development of antimicrobial HA doped thin films. In particular, HA doped with Ag (Ag:HA) is expected to inhibit the attachment of microbes and contamination of metallic implant surface. We herewith report on nano-sized HA and Ag:HA thin films synthesized by pulsed laser deposition on pure Ti and Ti modified with 100 nm diameter TiO2 nanotubes (fabricated by anodization of Ti plates) substrates. The HA-based thin films were characterized by SEM, AFM, EDS, FUR, and XRD. The cytotoxic activity was tested with HEp2 cells against controls. The antifungal efficiency of the deposited layers was tested against the Candida albicans and Aspergillus niger strains. The Ti substrates modified with TiO2 nanotubes covered with Ag...:HA thin films showed the highest antifungal activity.
Keywords:
Antifungal activity / Ag doped thin films / TiO2 nanotubes / Hydroxyapatite / Pulsed laser deposition
TY - JOUR
AU - Eraković, Sanja
AU - Janković, Ana
AU - Ristoscu, Carmen
AU - Duta, L.
AU - Serban, N.
AU - Visan, A.
AU - Mihailescu, Ion N.
AU - Stan, George E.
AU - Socol, M.
AU - Iordache, O.
AU - Dumitrescu, I.
AU - Luculescu, C. R.
AU - Janaćković, Đorđe
AU - Mišković-Stanković, Vesna
PY - 2014
UR - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/2816
AB - Hydroxyapatite (HA) is a widely used biomaterial for implant thin films, largely recognized for its excellent capability to chemically bond to hard tissue inducing the osteogenesis without immune response from human tissues. Nowadays, intense research efforts are focused on development of antimicrobial HA doped thin films. In particular, HA doped with Ag (Ag:HA) is expected to inhibit the attachment of microbes and contamination of metallic implant surface. We herewith report on nano-sized HA and Ag:HA thin films synthesized by pulsed laser deposition on pure Ti and Ti modified with 100 nm diameter TiO2 nanotubes (fabricated by anodization of Ti plates) substrates. The HA-based thin films were characterized by SEM, AFM, EDS, FUR, and XRD. The cytotoxic activity was tested with HEp2 cells against controls. The antifungal efficiency of the deposited layers was tested against the Candida albicans and Aspergillus niger strains. The Ti substrates modified with TiO2 nanotubes covered with Ag:HA thin films showed the highest antifungal activity.
PB - Elsevier Science Bv, Amsterdam
T2 - Applied Surface Science
T1 - Antifungal activity of Ag:hydroxyapatite thin films synthesized by pulsed laser deposition on Ti and Ti modified by TiO2 nanotubes substrates
EP - 45
SP - 37
VL - 293
DO - 10.1016/j.apsusc.2013.12.029
ER -
@article{
author = "Eraković, Sanja and Janković, Ana and Ristoscu, Carmen and Duta, L. and Serban, N. and Visan, A. and Mihailescu, Ion N. and Stan, George E. and Socol, M. and Iordache, O. and Dumitrescu, I. and Luculescu, C. R. and Janaćković, Đorđe and Mišković-Stanković, Vesna",
year = "2014",
abstract = "Hydroxyapatite (HA) is a widely used biomaterial for implant thin films, largely recognized for its excellent capability to chemically bond to hard tissue inducing the osteogenesis without immune response from human tissues. Nowadays, intense research efforts are focused on development of antimicrobial HA doped thin films. In particular, HA doped with Ag (Ag:HA) is expected to inhibit the attachment of microbes and contamination of metallic implant surface. We herewith report on nano-sized HA and Ag:HA thin films synthesized by pulsed laser deposition on pure Ti and Ti modified with 100 nm diameter TiO2 nanotubes (fabricated by anodization of Ti plates) substrates. The HA-based thin films were characterized by SEM, AFM, EDS, FUR, and XRD. The cytotoxic activity was tested with HEp2 cells against controls. The antifungal efficiency of the deposited layers was tested against the Candida albicans and Aspergillus niger strains. The Ti substrates modified with TiO2 nanotubes covered with Ag:HA thin films showed the highest antifungal activity.",
publisher = "Elsevier Science Bv, Amsterdam",
journal = "Applied Surface Science",
title = "Antifungal activity of Ag:hydroxyapatite thin films synthesized by pulsed laser deposition on Ti and Ti modified by TiO2 nanotubes substrates",
pages = "45-37",
volume = "293",
doi = "10.1016/j.apsusc.2013.12.029"
}
Eraković, S., Janković, A., Ristoscu, C., Duta, L., Serban, N., Visan, A., Mihailescu, I. N., Stan, G. E., Socol, M., Iordache, O., Dumitrescu, I., Luculescu, C. R., Janaćković, Đ.,& Mišković-Stanković, V.. (2014). Antifungal activity of Ag:hydroxyapatite thin films synthesized by pulsed laser deposition on Ti and Ti modified by TiO2 nanotubes substrates. in Applied Surface Science
Elsevier Science Bv, Amsterdam., 293, 37-45.
https://doi.org/10.1016/j.apsusc.2013.12.029
Eraković S, Janković A, Ristoscu C, Duta L, Serban N, Visan A, Mihailescu IN, Stan GE, Socol M, Iordache O, Dumitrescu I, Luculescu CR, Janaćković Đ, Mišković-Stanković V. Antifungal activity of Ag:hydroxyapatite thin films synthesized by pulsed laser deposition on Ti and Ti modified by TiO2 nanotubes substrates. in Applied Surface Science. 2014;293:37-45.
doi:10.1016/j.apsusc.2013.12.029 .
Eraković, Sanja, Janković, Ana, Ristoscu, Carmen, Duta, L., Serban, N., Visan, A., Mihailescu, Ion N., Stan, George E., Socol, M., Iordache, O., Dumitrescu, I., Luculescu, C. R., Janaćković, Đorđe, Mišković-Stanković, Vesna, "Antifungal activity of Ag:hydroxyapatite thin films synthesized by pulsed laser deposition on Ti and Ti modified by TiO2 nanotubes substrates" in Applied Surface Science, 293 (2014):37-45,
https://doi.org/10.1016/j.apsusc.2013.12.029 . .
