Antifungal activity of Ag:hydroxyapatite thin films synthesized by pulsed laser deposition on Ti and Ti modified by TiO2 nanotubes substrates
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2014
Authors
Eraković, Sanja
Janković, Ana

Ristoscu, Carmen

Duta, L.
Serban, N.
Visan, A.

Mihailescu, Ion N.
Stan, George E.

Socol, M.
Iordache, O.

Dumitrescu, I.
Luculescu, C. R.

Janaćković, Đorđe

Mišković-Stanković, Vesna

Article (Published version)

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Hydroxyapatite (HA) is a widely used biomaterial for implant thin films, largely recognized for its excellent capability to chemically bond to hard tissue inducing the osteogenesis without immune response from human tissues. Nowadays, intense research efforts are focused on development of antimicrobial HA doped thin films. In particular, HA doped with Ag (Ag:HA) is expected to inhibit the attachment of microbes and contamination of metallic implant surface. We herewith report on nano-sized HA and Ag:HA thin films synthesized by pulsed laser deposition on pure Ti and Ti modified with 100 nm diameter TiO2 nanotubes (fabricated by anodization of Ti plates) substrates. The HA-based thin films were characterized by SEM, AFM, EDS, FUR, and XRD. The cytotoxic activity was tested with HEp2 cells against controls. The antifungal efficiency of the deposited layers was tested against the Candida albicans and Aspergillus niger strains. The Ti substrates modified with TiO2 nanotubes covered with Ag...:HA thin films showed the highest antifungal activity.
Keywords:
Antifungal activity / Ag doped thin films / TiO2 nanotubes / Hydroxyapatite / Pulsed laser depositionSource:
Applied Surface Science, 2014, 293, 37-45Publisher:
- Elsevier Science Bv, Amsterdam
Funding / projects:
- Synthesis, processing and applications of nanostructured multifunctional materials with defined properties (RS-45019)
- UEFISCDI [ID 304/2011, TE49/2011]
DOI: 10.1016/j.apsusc.2013.12.029
ISSN: 0169-4332
WoS: 000330576600005
Scopus: 2-s2.0-84895059014
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Tehnološko-metalurški fakultetTY - JOUR AU - Eraković, Sanja AU - Janković, Ana AU - Ristoscu, Carmen AU - Duta, L. AU - Serban, N. AU - Visan, A. AU - Mihailescu, Ion N. AU - Stan, George E. AU - Socol, M. AU - Iordache, O. AU - Dumitrescu, I. AU - Luculescu, C. R. AU - Janaćković, Đorđe AU - Mišković-Stanković, Vesna PY - 2014 UR - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/2816 AB - Hydroxyapatite (HA) is a widely used biomaterial for implant thin films, largely recognized for its excellent capability to chemically bond to hard tissue inducing the osteogenesis without immune response from human tissues. Nowadays, intense research efforts are focused on development of antimicrobial HA doped thin films. In particular, HA doped with Ag (Ag:HA) is expected to inhibit the attachment of microbes and contamination of metallic implant surface. We herewith report on nano-sized HA and Ag:HA thin films synthesized by pulsed laser deposition on pure Ti and Ti modified with 100 nm diameter TiO2 nanotubes (fabricated by anodization of Ti plates) substrates. The HA-based thin films were characterized by SEM, AFM, EDS, FUR, and XRD. The cytotoxic activity was tested with HEp2 cells against controls. The antifungal efficiency of the deposited layers was tested against the Candida albicans and Aspergillus niger strains. The Ti substrates modified with TiO2 nanotubes covered with Ag:HA thin films showed the highest antifungal activity. PB - Elsevier Science Bv, Amsterdam T2 - Applied Surface Science T1 - Antifungal activity of Ag:hydroxyapatite thin films synthesized by pulsed laser deposition on Ti and Ti modified by TiO2 nanotubes substrates EP - 45 SP - 37 VL - 293 DO - 10.1016/j.apsusc.2013.12.029 ER -
@article{ author = "Eraković, Sanja and Janković, Ana and Ristoscu, Carmen and Duta, L. and Serban, N. and Visan, A. and Mihailescu, Ion N. and Stan, George E. and Socol, M. and Iordache, O. and Dumitrescu, I. and Luculescu, C. R. and Janaćković, Đorđe and Mišković-Stanković, Vesna", year = "2014", abstract = "Hydroxyapatite (HA) is a widely used biomaterial for implant thin films, largely recognized for its excellent capability to chemically bond to hard tissue inducing the osteogenesis without immune response from human tissues. Nowadays, intense research efforts are focused on development of antimicrobial HA doped thin films. In particular, HA doped with Ag (Ag:HA) is expected to inhibit the attachment of microbes and contamination of metallic implant surface. We herewith report on nano-sized HA and Ag:HA thin films synthesized by pulsed laser deposition on pure Ti and Ti modified with 100 nm diameter TiO2 nanotubes (fabricated by anodization of Ti plates) substrates. The HA-based thin films were characterized by SEM, AFM, EDS, FUR, and XRD. The cytotoxic activity was tested with HEp2 cells against controls. The antifungal efficiency of the deposited layers was tested against the Candida albicans and Aspergillus niger strains. The Ti substrates modified with TiO2 nanotubes covered with Ag:HA thin films showed the highest antifungal activity.", publisher = "Elsevier Science Bv, Amsterdam", journal = "Applied Surface Science", title = "Antifungal activity of Ag:hydroxyapatite thin films synthesized by pulsed laser deposition on Ti and Ti modified by TiO2 nanotubes substrates", pages = "45-37", volume = "293", doi = "10.1016/j.apsusc.2013.12.029" }
Eraković, S., Janković, A., Ristoscu, C., Duta, L., Serban, N., Visan, A., Mihailescu, I. N., Stan, G. E., Socol, M., Iordache, O., Dumitrescu, I., Luculescu, C. R., Janaćković, Đ.,& Mišković-Stanković, V.. (2014). Antifungal activity of Ag:hydroxyapatite thin films synthesized by pulsed laser deposition on Ti and Ti modified by TiO2 nanotubes substrates. in Applied Surface Science Elsevier Science Bv, Amsterdam., 293, 37-45. https://doi.org/10.1016/j.apsusc.2013.12.029
Eraković S, Janković A, Ristoscu C, Duta L, Serban N, Visan A, Mihailescu IN, Stan GE, Socol M, Iordache O, Dumitrescu I, Luculescu CR, Janaćković Đ, Mišković-Stanković V. Antifungal activity of Ag:hydroxyapatite thin films synthesized by pulsed laser deposition on Ti and Ti modified by TiO2 nanotubes substrates. in Applied Surface Science. 2014;293:37-45. doi:10.1016/j.apsusc.2013.12.029 .
Eraković, Sanja, Janković, Ana, Ristoscu, Carmen, Duta, L., Serban, N., Visan, A., Mihailescu, Ion N., Stan, George E., Socol, M., Iordache, O., Dumitrescu, I., Luculescu, C. R., Janaćković, Đorđe, Mišković-Stanković, Vesna, "Antifungal activity of Ag:hydroxyapatite thin films synthesized by pulsed laser deposition on Ti and Ti modified by TiO2 nanotubes substrates" in Applied Surface Science, 293 (2014):37-45, https://doi.org/10.1016/j.apsusc.2013.12.029 . .