The oxidative ability of donepezil, a frequently prescribed drug for the treatment of Alzheimer's disease is reported for the first time at a gold electrode. It was oxidized by cyclic voltammetry and determined by square wave voltammetry in phosphate buffer electrolyte. Electrochemical degradation of donepezil was carried out by long term potential cycling. The identification and characterization of the major product, isolated by preparative high performance liquid chromatography, was performed by high resolution mass spectrometry and 1D and 2D nuclear magnetic resonance spectroscopy. Donepezil hydroxy derivative was identified as the major electrochemical oxidation product from donepezil.
TY - JOUR
AU - Mladenović, Aleksandar R.
AU - Mijin, Dušan
AU - Drmanić, Saša
AU - Vajs, Vlatka
AU - Jovanović, Vladislava M.
AU - Petrović, Slobodan
AU - Avramov-Ivić, Milka
PY - 2014
UR - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/2820
AB - The oxidative ability of donepezil, a frequently prescribed drug for the treatment of Alzheimer's disease is reported for the first time at a gold electrode. It was oxidized by cyclic voltammetry and determined by square wave voltammetry in phosphate buffer electrolyte. Electrochemical degradation of donepezil was carried out by long term potential cycling. The identification and characterization of the major product, isolated by preparative high performance liquid chromatography, was performed by high resolution mass spectrometry and 1D and 2D nuclear magnetic resonance spectroscopy. Donepezil hydroxy derivative was identified as the major electrochemical oxidation product from donepezil.
PB - Wiley-VCH Verlag Gmbh, Weinheim
T2 - Electroanalysis
T1 - Electrochemical Oxidation of Donepezil and Its Voltammetric Determination at Gold Electrode
EP - 897
IS - 5
SP - 893
VL - 26
DO - 10.1002/elan.201400034
ER -
@article{
author = "Mladenović, Aleksandar R. and Mijin, Dušan and Drmanić, Saša and Vajs, Vlatka and Jovanović, Vladislava M. and Petrović, Slobodan and Avramov-Ivić, Milka",
year = "2014",
abstract = "The oxidative ability of donepezil, a frequently prescribed drug for the treatment of Alzheimer's disease is reported for the first time at a gold electrode. It was oxidized by cyclic voltammetry and determined by square wave voltammetry in phosphate buffer electrolyte. Electrochemical degradation of donepezil was carried out by long term potential cycling. The identification and characterization of the major product, isolated by preparative high performance liquid chromatography, was performed by high resolution mass spectrometry and 1D and 2D nuclear magnetic resonance spectroscopy. Donepezil hydroxy derivative was identified as the major electrochemical oxidation product from donepezil.",
publisher = "Wiley-VCH Verlag Gmbh, Weinheim",
journal = "Electroanalysis",
title = "Electrochemical Oxidation of Donepezil and Its Voltammetric Determination at Gold Electrode",
pages = "897-893",
number = "5",
volume = "26",
doi = "10.1002/elan.201400034"
}
Mladenović, A. R., Mijin, D., Drmanić, S., Vajs, V., Jovanović, V. M., Petrović, S.,& Avramov-Ivić, M.. (2014). Electrochemical Oxidation of Donepezil and Its Voltammetric Determination at Gold Electrode. in Electroanalysis
Wiley-VCH Verlag Gmbh, Weinheim., 26(5), 893-897.
https://doi.org/10.1002/elan.201400034
Mladenović AR, Mijin D, Drmanić S, Vajs V, Jovanović VM, Petrović S, Avramov-Ivić M. Electrochemical Oxidation of Donepezil and Its Voltammetric Determination at Gold Electrode. in Electroanalysis. 2014;26(5):893-897.
doi:10.1002/elan.201400034 .
Mladenović, Aleksandar R., Mijin, Dušan, Drmanić, Saša, Vajs, Vlatka, Jovanović, Vladislava M., Petrović, Slobodan, Avramov-Ivić, Milka, "Electrochemical Oxidation of Donepezil and Its Voltammetric Determination at Gold Electrode" in Electroanalysis, 26, no. 5 (2014):893-897,
https://doi.org/10.1002/elan.201400034 . .
