Electrochemical Oxidation of Donepezil and Its Voltammetric Determination at Gold Electrode
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2014
Authors
Mladenović, Aleksandar R.Mijin, Dušan
Drmanić, Saša
Vajs, Vlatka
Jovanović, Vladislava M.
Petrović, Slobodan
Avramov-Ivić, Milka
Article (Published version)
Metadata
Show full item recordAbstract
The oxidative ability of donepezil, a frequently prescribed drug for the treatment of Alzheimer's disease is reported for the first time at a gold electrode. It was oxidized by cyclic voltammetry and determined by square wave voltammetry in phosphate buffer electrolyte. Electrochemical degradation of donepezil was carried out by long term potential cycling. The identification and characterization of the major product, isolated by preparative high performance liquid chromatography, was performed by high resolution mass spectrometry and 1D and 2D nuclear magnetic resonance spectroscopy. Donepezil hydroxy derivative was identified as the major electrochemical oxidation product from donepezil.
Keywords:
Cyclic voltammetry / Donepezil / Gold electrode / Oxidation / Square wave voltammetrySource:
Electroanalysis, 2014, 26, 5, 893-897Publisher:
- Wiley-VCH Verlag Gmbh, Weinheim
Funding / projects:
- Study of the Synthesis, Structure and Activity of Natural and Synthetic Organic Compounds (RS-MESTD-Basic Research (BR or ON)-172013)
DOI: 10.1002/elan.201400034
ISSN: 1040-0397
WoS: 000335997600001
Scopus: 2-s2.0-84900331905
Institution/Community
Tehnološko-metalurški fakultetTY - JOUR AU - Mladenović, Aleksandar R. AU - Mijin, Dušan AU - Drmanić, Saša AU - Vajs, Vlatka AU - Jovanović, Vladislava M. AU - Petrović, Slobodan AU - Avramov-Ivić, Milka PY - 2014 UR - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/2820 AB - The oxidative ability of donepezil, a frequently prescribed drug for the treatment of Alzheimer's disease is reported for the first time at a gold electrode. It was oxidized by cyclic voltammetry and determined by square wave voltammetry in phosphate buffer electrolyte. Electrochemical degradation of donepezil was carried out by long term potential cycling. The identification and characterization of the major product, isolated by preparative high performance liquid chromatography, was performed by high resolution mass spectrometry and 1D and 2D nuclear magnetic resonance spectroscopy. Donepezil hydroxy derivative was identified as the major electrochemical oxidation product from donepezil. PB - Wiley-VCH Verlag Gmbh, Weinheim T2 - Electroanalysis T1 - Electrochemical Oxidation of Donepezil and Its Voltammetric Determination at Gold Electrode EP - 897 IS - 5 SP - 893 VL - 26 DO - 10.1002/elan.201400034 ER -
@article{ author = "Mladenović, Aleksandar R. and Mijin, Dušan and Drmanić, Saša and Vajs, Vlatka and Jovanović, Vladislava M. and Petrović, Slobodan and Avramov-Ivić, Milka", year = "2014", abstract = "The oxidative ability of donepezil, a frequently prescribed drug for the treatment of Alzheimer's disease is reported for the first time at a gold electrode. It was oxidized by cyclic voltammetry and determined by square wave voltammetry in phosphate buffer electrolyte. Electrochemical degradation of donepezil was carried out by long term potential cycling. The identification and characterization of the major product, isolated by preparative high performance liquid chromatography, was performed by high resolution mass spectrometry and 1D and 2D nuclear magnetic resonance spectroscopy. Donepezil hydroxy derivative was identified as the major electrochemical oxidation product from donepezil.", publisher = "Wiley-VCH Verlag Gmbh, Weinheim", journal = "Electroanalysis", title = "Electrochemical Oxidation of Donepezil and Its Voltammetric Determination at Gold Electrode", pages = "897-893", number = "5", volume = "26", doi = "10.1002/elan.201400034" }
Mladenović, A. R., Mijin, D., Drmanić, S., Vajs, V., Jovanović, V. M., Petrović, S.,& Avramov-Ivić, M.. (2014). Electrochemical Oxidation of Donepezil and Its Voltammetric Determination at Gold Electrode. in Electroanalysis Wiley-VCH Verlag Gmbh, Weinheim., 26(5), 893-897. https://doi.org/10.1002/elan.201400034
Mladenović AR, Mijin D, Drmanić S, Vajs V, Jovanović VM, Petrović S, Avramov-Ivić M. Electrochemical Oxidation of Donepezil and Its Voltammetric Determination at Gold Electrode. in Electroanalysis. 2014;26(5):893-897. doi:10.1002/elan.201400034 .
Mladenović, Aleksandar R., Mijin, Dušan, Drmanić, Saša, Vajs, Vlatka, Jovanović, Vladislava M., Petrović, Slobodan, Avramov-Ivić, Milka, "Electrochemical Oxidation of Donepezil and Its Voltammetric Determination at Gold Electrode" in Electroanalysis, 26, no. 5 (2014):893-897, https://doi.org/10.1002/elan.201400034 . .