Uracil derivatives are potentially biologically active compounds, so the investigation of their physical and chemical properties is very important for their further application. In this work a series of newly synthesized derivatives of uracil was investigated by applying the spectrophotometric method. The absorption spectra were recorded in seventeen solvents with different properties. The effect of solvent was interpreted by Kamlet-Taft solvatochromic model. The dominance and the types of interactions that occur between the investigated derivatives and solvent were interpreted by applying the multiple linear correlation obtained values of absorption maxima and Hansen's solvent parameters. In addition to the effect of solvent, the influence of substituents in the molecule on absorption spectra was studied by applying Hammett equation.
Derivati uracila predstavljaju potencijalno biološki aktivna jedinjenja, pa je ispitivanje njihovih fizičko- hemijskih svojstava veoma značajno za njihovu dalju primenu. U ovom radu je ispitana serija novosintetisanih derivata uracila primenom spektrofotometrijske metode. Apsorpcioni spektri su snimljeni u sedamnaest rastvarača različitih svojstava. Uticaj rastvarača na apsorpcione spektre tumačen je primenom Kamlet-Taft-ovog solvatohromnog modela. Dominantnost i vrste interakcija koje se javljaju između ispitivanih derivata i rastvarača analizirane su metodom višestruke linearne korelacije dobijenih vrednosti položaja apsorpcionih maksimuma i Hansen-ovih parametara rastvarača. Pored uticaja rastvarača, tumačen je i uticaj supstituenta prisutnog u molekulu na apsorpcione spektre pomoću Hammett-ove jednačine.
TY - JOUR
AU - Matijević, Borko M.
AU - Vaštag, Đenđi
AU - Apostolov, Suzana
AU - Tot, Jadranka
AU - Assaleh, Fathi H.
AU - Marinković, Aleksandar
PY - 2015
UR - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/2962
AB - Uracil derivatives are potentially biologically active compounds, so the investigation of their physical and chemical properties is very important for their further application. In this work a series of newly synthesized derivatives of uracil was investigated by applying the spectrophotometric method. The absorption spectra were recorded in seventeen solvents with different properties. The effect of solvent was interpreted by Kamlet-Taft solvatochromic model. The dominance and the types of interactions that occur between the investigated derivatives and solvent were interpreted by applying the multiple linear correlation obtained values of absorption maxima and Hansen's solvent parameters. In addition to the effect of solvent, the influence of substituents in the molecule on absorption spectra was studied by applying Hammett equation.
AB - Derivati uracila predstavljaju potencijalno biološki aktivna jedinjenja, pa je ispitivanje njihovih fizičko- hemijskih svojstava veoma značajno za njihovu dalju primenu. U ovom radu je ispitana serija novosintetisanih derivata uracila primenom spektrofotometrijske metode. Apsorpcioni spektri su snimljeni u sedamnaest rastvarača različitih svojstava. Uticaj rastvarača na apsorpcione spektre tumačen je primenom Kamlet-Taft-ovog solvatohromnog modela. Dominantnost i vrste interakcija koje se javljaju između ispitivanih derivata i rastvarača analizirane su metodom višestruke linearne korelacije dobijenih vrednosti položaja apsorpcionih maksimuma i Hansen-ovih parametara rastvarača. Pored uticaja rastvarača, tumačen je i uticaj supstituenta prisutnog u molekulu na apsorpcione spektre pomoću Hammett-ove jednačine.
PB - Engineering Society for Corrosion, Belgrade, Serbia
T2 - Zaštita materijala
T1 - Studying of physicochemical properties of newly synthesized uracil derivatives
T1 - Proučavanje fizičko-hemijskih svojstava novosintetisanih derivata uracila
EP - 288
IS - 3
SP - 279
VL - 56
DO - 10.5937/ZasMat1503279M
ER -
@article{
author = "Matijević, Borko M. and Vaštag, Đenđi and Apostolov, Suzana and Tot, Jadranka and Assaleh, Fathi H. and Marinković, Aleksandar",
year = "2015",
abstract = "Uracil derivatives are potentially biologically active compounds, so the investigation of their physical and chemical properties is very important for their further application. In this work a series of newly synthesized derivatives of uracil was investigated by applying the spectrophotometric method. The absorption spectra were recorded in seventeen solvents with different properties. The effect of solvent was interpreted by Kamlet-Taft solvatochromic model. The dominance and the types of interactions that occur between the investigated derivatives and solvent were interpreted by applying the multiple linear correlation obtained values of absorption maxima and Hansen's solvent parameters. In addition to the effect of solvent, the influence of substituents in the molecule on absorption spectra was studied by applying Hammett equation., Derivati uracila predstavljaju potencijalno biološki aktivna jedinjenja, pa je ispitivanje njihovih fizičko- hemijskih svojstava veoma značajno za njihovu dalju primenu. U ovom radu je ispitana serija novosintetisanih derivata uracila primenom spektrofotometrijske metode. Apsorpcioni spektri su snimljeni u sedamnaest rastvarača različitih svojstava. Uticaj rastvarača na apsorpcione spektre tumačen je primenom Kamlet-Taft-ovog solvatohromnog modela. Dominantnost i vrste interakcija koje se javljaju između ispitivanih derivata i rastvarača analizirane su metodom višestruke linearne korelacije dobijenih vrednosti položaja apsorpcionih maksimuma i Hansen-ovih parametara rastvarača. Pored uticaja rastvarača, tumačen je i uticaj supstituenta prisutnog u molekulu na apsorpcione spektre pomoću Hammett-ove jednačine.",
publisher = "Engineering Society for Corrosion, Belgrade, Serbia",
journal = "Zaštita materijala",
title = "Studying of physicochemical properties of newly synthesized uracil derivatives, Proučavanje fizičko-hemijskih svojstava novosintetisanih derivata uracila",
pages = "288-279",
number = "3",
volume = "56",
doi = "10.5937/ZasMat1503279M"
}
Matijević, B. M., Vaštag, Đ., Apostolov, S., Tot, J., Assaleh, F. H.,& Marinković, A.. (2015). Studying of physicochemical properties of newly synthesized uracil derivatives. in Zaštita materijala
Engineering Society for Corrosion, Belgrade, Serbia., 56(3), 279-288.
https://doi.org/10.5937/ZasMat1503279M
Matijević BM, Vaštag Đ, Apostolov S, Tot J, Assaleh FH, Marinković A. Studying of physicochemical properties of newly synthesized uracil derivatives. in Zaštita materijala. 2015;56(3):279-288.
doi:10.5937/ZasMat1503279M .
Matijević, Borko M., Vaštag, Đenđi, Apostolov, Suzana, Tot, Jadranka, Assaleh, Fathi H., Marinković, Aleksandar, "Studying of physicochemical properties of newly synthesized uracil derivatives" in Zaštita materijala, 56, no. 3 (2015):279-288,
https://doi.org/10.5937/ZasMat1503279M . .
