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dc.creatorJanković, Ana
dc.creatorEraković, Sanja
dc.creatorRistoscu, Carmen
dc.creatorMihailescu, Ion N.
dc.creatorDuta, L.
dc.creatorVisan, A.
dc.creatorStan, George E.
dc.creatorPopa, A. C.
dc.creatorHusanu, M. A.
dc.creatorLuculescu, C. R.
dc.creatorSrdić, Vladimir V.
dc.creatorJanaćković, Đorđe
dc.creatorMišković-Stanković, Vesna
dc.creatorBleotu, C.
dc.creatorChifiriuc, M. C.
dc.creatorMihailescu, Ion N.
dc.date.accessioned2021-03-10T12:48:34Z
dc.date.available2021-03-10T12:48:34Z
dc.date.issued2015
dc.identifier.issn0957-4530
dc.identifier.urihttp://TechnoRep.tmf.bg.ac.rs/handle/123456789/3042
dc.description.abstractWe report on thin film deposition by matrix-assisted pulsed laser evaporation of simple hydroxyapatite (HA) or silver (Ag) doped HA combined with the natural biopolymer organosolv lignin (Lig) (Ag:HA-Lig). Solid cryogenic target of aqueous dispersions of Ag:HA-Lig composite and its counterpart without silver (HA-Lig) were prepared for evaporation using a KrF* excimer laser source. The expulsed material was assembled onto TiO2/Ti substrata or silicon wafers and subjected to physical-chemical investigations. Smooth, uniform films adherent to substratum were observed. The chemical analyses confirmed the presence of the HA components, but also evidenced traces of Ag and Lig. Deposited HA was Ca deficient, which is indicative of a film with increased solubility. Recorded X-ray Diffraction patterns were characteristic for amorphous films. Lig presence in thin films was undoubtedly proved by both X-ray Photoelectron and Fourier Transform Infra-Red Spectroscopy analyses. The microbiological evaluation showed that the newly assembled surfaces exhibited an inhibitory activity both on the initial steps of biofilm forming, and on mature bacterial and fungal biofilm development. The intensity of the antibiofilm activity was positively influenced by the presence of the Lig and/or Ag, in the case of Staphylococcus aureus, Pseudomonas aeruginosa and Candida famata biofilms. The obtained surfaces exhibited a low cytotoxicity toward human mesenchymal stem cells, being therefore promising candidates for fabricating implantable biomaterials with increased biocompatibility and resistance to microbial colonization and further biofilm development.en
dc.publisherSpringer, Dordrecht
dc.relationExecutive Unit for Financing Higher Education, Research, Development and Innovation (UEFISCDI) of Romania [304/2011, TE82/2011]
dc.relationinfo:eu-repo/grantAgreement/EC/FP7/245916/EU//
dc.relationinfo:eu-repo/grantAgreement/MESTD/Integrated and Interdisciplinary Research (IIR or III)/45019/RS//
dc.relation[TE 49/2011]
dc.rightsrestrictedAccess
dc.sourceJournal of Materials Science-Materials in Medicine
dc.titleStructural and biological evaluation of lignin addition to simple and silver-doped hydroxyapatite thin films synthesized by matrix-assisted pulsed laser evaporationen
dc.typearticle
dc.rights.licenseARR
dc.citation.issue1
dc.citation.other26(1): -
dc.citation.rankM22
dc.citation.volume26
dc.identifier.doi10.1007/s10856-014-5333-y
dc.identifier.pmid25578691
dc.identifier.scopus2-s2.0-84983585727
dc.identifier.wos000349016900017
dc.type.versionpublishedVersion


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