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dc.creatorVunduk, Jovana
dc.creatorKlaus, Anita
dc.creatorKozarski, Maja
dc.creatorPetrović, Predrag
dc.creatorŽižak, Željko
dc.creatorNikšić, Miomir
dc.creatorvan Griensven, Leo
dc.date.accessioned2021-03-10T12:50:30Z
dc.date.available2021-03-10T12:50:30Z
dc.date.issued2015
dc.identifier.issn1521-9437
dc.identifier.urihttp://TechnoRep.tmf.bg.ac.rs/handle/123456789/3072
dc.description.abstractThe birch polypore Piptoporus betulinus was among two mushrooms that were found in the Iceman's bag. Recent studies indicated that P. betulinus was probably used as a religious and medicinal item. In order to examine the medicinal potential of P. betulinus, hot water (HW), partially purified (PP), and alkali extract (HA) were prepared and tested for antioxidant, antimicrobial, cytotoxic, and angiotensin I-converting enzyme (ACE) inhibitory activity. All tested samples exhibited moderate cytotoxic activity, and HW appeared as the most effective (IC50 = 0.8 +/- 0.1 mg/ml for HeLa cells). HA proved to be a good 1,1-diphenyl-2-picrylhydrazyl radical scavenger and exhibited the strongest ferric-reducing power (EC50 = 0.07 +/- 0.3 mg/ml). The same extract (HA) also expressed the strongest ferric-reducing power (EC50 = 0.99 +/- 0.1 mg/ml). Hot alkali extraction contributed significantly to ACE inhibitory activity (EC50 = 0.06 +/- 0.00 mg/ml) and to antimicrobial activity, especially against highly resistant Enterococcus faecalis (minimum inhibitory concentration: 0.156 +/- 0.000 mg/ml; and minimum bactericidal concentration: 1.25 +/- 0.00 mg/ml).en
dc.publisherBegell House Inc, Danbury
dc.relationinfo:eu-repo/grantAgreement/EC/FP7/316004/EU//
dc.relationinfo:eu-repo/grantAgreement/MESTD/Integrated and Interdisciplinary Research (IIR or III)/46001/RS//
dc.relationinfo:eu-repo/grantAgreement/MESTD/Integrated and Interdisciplinary Research (IIR or III)/46010/RS//
dc.rightsrestrictedAccess
dc.sourceInternational Journal of Medicinal Mushrooms
dc.subjectmedicinal mushroomsen
dc.subjectangiotensin I-converting enzyme (ACE)en
dc.subjectantioxidant activityen
dc.subjectcytotoxic activityen
dc.subjectEnterococcus faecalisen
dc.subjectIcemanen
dc.subjectPiptoporus betulinusen
dc.titleDid the Iceman Know Better? Screening of the Medicinal Properties of the Birch Polypore Medicinal Mushroom, Piptoporus betulinus (Higher Basidiomycetes)en
dc.typearticle
dc.rights.licenseARR
dc.citation.epage1125
dc.citation.issue12
dc.citation.other17(12): 1113-1125
dc.citation.rankM23
dc.citation.spage1113
dc.citation.volume17
dc.identifier.doi10.1615/IntJMedMushrooms.v17.i12.10
dc.identifier.pmid26854098
dc.identifier.scopus2-s2.0-84955461039
dc.identifier.wos000368923000001
dc.type.versionpublishedVersion


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