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dc.creatorPerić, Tamara
dc.creatorMarković, Dejan
dc.creatorPetrović, Bojan
dc.creatorRadojević, Vesna
dc.creatorTodorović, Tatjana
dc.creatorAnđelski-Radičević, Biljana
dc.creatorJančić-Heinemann, Radmila
dc.creatorSusić, Gordana
dc.creatorPerić‐Popadić, Aleksandra
dc.creatorTomić-Spirić, Vesna
dc.date.accessioned2021-03-10T12:52:23Z
dc.date.available2021-03-10T12:52:23Z
dc.date.issued2015
dc.identifier.issn1432-6981
dc.identifier.urihttp://TechnoRep.tmf.bg.ac.rs/handle/123456789/3101
dc.description.abstractThe purpose of this study was to evaluate efficacy of casein phosphopeptide-amorphous calcium phosphate (CPP-ACP) and casein phosphopeptide-amorphous calcium fluoride phosphate (CPP-ACFP) containing pastes among individuals with Sjogren's syndrome (SS). Thirty patients were randomised into three groups: CPP-ACP, CPP-ACFP, and 0.05 % NaF to be used two times a day during a 28-day experimental period. Saliva was analysed for flow rate, pH, buffering capacity and mineral concentrations. Dental plaque was examined for pH. Following the formation of artificial carious lesion, participants wore enamel slabs for an in situ remineralisation study. Remineralisation potential was examined using scanning electron microscope (SEM) and energy dispersive spectroscopic (EDS) technique. SE microphotographs were subsequently analysed for area, diameter, perimeter, roundness and the number of enamel defects and percentage of tooth surface affected by defects. At the end of the experimental period, a slight increase of salivary pH could have been observed. No differences in mineral composition of saliva were noted. The use of CPP-ACP and CPP-ACFP contributed to a significant rise of plaque pH. Image analysis revealed excessive reduction of defects' dimensions in the three experimental groups, and a decrease of the number of enamel defects in the CPP-ACP and CPP-ACFP groups. The EDS analysis did not show differences in Ca/P, Ca/O and P/O ratios in any of the treatment groups. CPP-ACP and CPP-ACFP hold promise as remineralising agents for patients with SS. Pastes containing CPP-ACP/CPP-ACFP show enhanced remineralisation potential compared with NaF mouthrinse in patients with SS.en
dc.publisherSpringer Heidelberg, Heidelberg
dc.rightsrestrictedAccess
dc.sourceClinical Oral Investigations
dc.subjectCasein phosphopeptide-amorphous calcium phosphateen
dc.subjectCasein phosphopeptide-amorphous calcium fluoride phosphateen
dc.subjectSjogren's syndromeen
dc.subjectSalivaen
dc.subjectDental plaqueen
dc.subjectEnamel remineralisationen
dc.titleEfficacy of pastes containing CPP-ACP and CPP-ACFP in patients with Sjogren's syndromeen
dc.typearticle
dc.rights.licenseARR
dc.citation.epage2165
dc.citation.issue9
dc.citation.other19(9): 2153-2165
dc.citation.rankM21
dc.citation.spage2153
dc.citation.volume19
dc.identifier.doi10.1007/s00784-015-1444-1
dc.identifier.pmid25762499
dc.identifier.rcubconv_4850
dc.identifier.scopus2-s2.0-84948113270
dc.identifier.wos000365519800001
dc.type.versionpublishedVersion


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