Novel nanocomposite containing fullerenol nanoparticles (FNP) and porous silica nanoparticles (PSNs) was constructed and characterized. The capability of FNP to serve as a pore-capping agent and for entrapping 9-aminoacridine (9-AA) inside the pores of the PSN material was also demonstrated. Nitrogen sorption measurements evidence the successful capping of the silica pores while thermogravimetric analysis of FNP loaded PSN indicates the existence of pore-loaded fullerenol molecules. Higher amount of the drug release was noted by exposing the material to weakly acidic conditions in comparison to physiological pH, which may find application in targeted treatment of weakly acidic tumor tissues.
Source:
Advances in Materials Science and Engineering, 2015, 2015
TY - JOUR
AU - Knezević, Nikola C.
AU - Milenković, Sanja
AU - Jović, Danica
AU - Lazarević, Slavica
AU - Mrdjanović, Jasminka
AU - Đorđević, Aleksandar
PY - 2015
UR - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/3130
AB - Novel nanocomposite containing fullerenol nanoparticles (FNP) and porous silica nanoparticles (PSNs) was constructed and characterized. The capability of FNP to serve as a pore-capping agent and for entrapping 9-aminoacridine (9-AA) inside the pores of the PSN material was also demonstrated. Nitrogen sorption measurements evidence the successful capping of the silica pores while thermogravimetric analysis of FNP loaded PSN indicates the existence of pore-loaded fullerenol molecules. Higher amount of the drug release was noted by exposing the material to weakly acidic conditions in comparison to physiological pH, which may find application in targeted treatment of weakly acidic tumor tissues.
PB - Hindawi Ltd, London
T2 - Advances in Materials Science and Engineering
T1 - Fullerenol-Capped Porous Silica Nanoparticles for pH-Responsive Drug Delivery
VL - 2015
DO - 10.1155/2015/567350
ER -
@article{
author = "Knezević, Nikola C. and Milenković, Sanja and Jović, Danica and Lazarević, Slavica and Mrdjanović, Jasminka and Đorđević, Aleksandar",
year = "2015",
abstract = "Novel nanocomposite containing fullerenol nanoparticles (FNP) and porous silica nanoparticles (PSNs) was constructed and characterized. The capability of FNP to serve as a pore-capping agent and for entrapping 9-aminoacridine (9-AA) inside the pores of the PSN material was also demonstrated. Nitrogen sorption measurements evidence the successful capping of the silica pores while thermogravimetric analysis of FNP loaded PSN indicates the existence of pore-loaded fullerenol molecules. Higher amount of the drug release was noted by exposing the material to weakly acidic conditions in comparison to physiological pH, which may find application in targeted treatment of weakly acidic tumor tissues.",
publisher = "Hindawi Ltd, London",
journal = "Advances in Materials Science and Engineering",
title = "Fullerenol-Capped Porous Silica Nanoparticles for pH-Responsive Drug Delivery",
volume = "2015",
doi = "10.1155/2015/567350"
}
Knezević, N. C., Milenković, S., Jović, D., Lazarević, S., Mrdjanović, J.,& Đorđević, A.. (2015). Fullerenol-Capped Porous Silica Nanoparticles for pH-Responsive Drug Delivery. in Advances in Materials Science and Engineering
Hindawi Ltd, London., 2015.
https://doi.org/10.1155/2015/567350
Knezević NC, Milenković S, Jović D, Lazarević S, Mrdjanović J, Đorđević A. Fullerenol-Capped Porous Silica Nanoparticles for pH-Responsive Drug Delivery. in Advances in Materials Science and Engineering. 2015;2015.
doi:10.1155/2015/567350 .
Knezević, Nikola C., Milenković, Sanja, Jović, Danica, Lazarević, Slavica, Mrdjanović, Jasminka, Đorđević, Aleksandar, "Fullerenol-Capped Porous Silica Nanoparticles for pH-Responsive Drug Delivery" in Advances in Materials Science and Engineering, 2015 (2015),
https://doi.org/10.1155/2015/567350 . .
