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A high efficacy antimicrobial acrylate based hydrogels with incorporated copper for wound healing application

Authorized Users Only
2015
Authors
Vuković, Jovana
Babić, Marija
Antić, Katarina
Miljković, Miona
Perić-Grujić, Aleksandra
Filipović, Jovanka M.
Tomić, Simonida
Article (Published version)
Metadata
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Abstract
In this study, three series of hydrogels based on 2-hydroxyethyl acrylate and itaconic acid, unloaded, with incorporated copper(II) ions and reduced copper, were successfully prepared, characterized and evaluated as novel wound healing materials. Fourier transform infrared spectroscopy (FTIR) confirmed the expected structure of obtained hydrogels. Scanning electron microscopy (SEM) revealed porous morphology of unloaded hydrogels, and the morphological modifications in case of loaded hydrogels. Thermal characteristics were examined by differential scanning calorimetry (DSC) and the glass transition temperatures were observed in range of 12-50 degrees C. Swelling study was conducted in wide range of pHs at 37 degrees C, confirming pH sensitive behaviour for all three series of hydrogels. The in vitro copper release was investigated and the experimental data were analysed using several models in order to elucidate the transport mechanism. The antimicrobial assay revealed excellent antimi...crobial activity, over 99% against Escherichia coli, Staphylococcus aureus and Candida albicans, as well as good correlation with the copper release experiments. In accordance with potential application, water vapour transmission rate, oxygen penetration, dispersion characteristics, fluid retention were observed and the suitability of the hydrogels for wound healing application was discussed.

Keywords:
Polymers / Thermal properties / Transport properties / Biomaterials
Source:
Materials Chemistry and Physics, 2015, 164, 51-62
Publisher:
  • Elsevier Science Sa, Lausanne
Funding / projects:
  • Synthesis and characterization of novel functional polymers and polymeric nanocomposites (RS-172062)
  • Chemical and structural designing of nanomaterials for application in medicine and tissue engineering (RS-172026)

DOI: 10.1016/j.matchemphys.2015.08.022

ISSN: 0254-0584

WoS: 000362144800008

Scopus: 2-s2.0-84941413164
[ Google Scholar ]
9
7
URI
http://TechnoRep.tmf.bg.ac.rs/handle/123456789/3139
Collections
  • Radovi istraživača / Researchers’ publications (TMF)
  • Radovi istraživača (Inovacioni centar) / Researchers’ publications (Innovation Centre)
Institution/Community
Tehnološko-metalurški fakultet
TY  - JOUR
AU  - Vuković, Jovana
AU  - Babić, Marija
AU  - Antić, Katarina
AU  - Miljković, Miona
AU  - Perić-Grujić, Aleksandra
AU  - Filipović, Jovanka M.
AU  - Tomić, Simonida
PY  - 2015
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/3139
AB  - In this study, three series of hydrogels based on 2-hydroxyethyl acrylate and itaconic acid, unloaded, with incorporated copper(II) ions and reduced copper, were successfully prepared, characterized and evaluated as novel wound healing materials. Fourier transform infrared spectroscopy (FTIR) confirmed the expected structure of obtained hydrogels. Scanning electron microscopy (SEM) revealed porous morphology of unloaded hydrogels, and the morphological modifications in case of loaded hydrogels. Thermal characteristics were examined by differential scanning calorimetry (DSC) and the glass transition temperatures were observed in range of 12-50 degrees C. Swelling study was conducted in wide range of pHs at 37 degrees C, confirming pH sensitive behaviour for all three series of hydrogels. The in vitro copper release was investigated and the experimental data were analysed using several models in order to elucidate the transport mechanism. The antimicrobial assay revealed excellent antimicrobial activity, over 99% against Escherichia coli, Staphylococcus aureus and Candida albicans, as well as good correlation with the copper release experiments. In accordance with potential application, water vapour transmission rate, oxygen penetration, dispersion characteristics, fluid retention were observed and the suitability of the hydrogels for wound healing application was discussed.
PB  - Elsevier Science Sa, Lausanne
T2  - Materials Chemistry and Physics
T1  - A high efficacy antimicrobial acrylate based hydrogels with incorporated copper for wound healing application
EP  - 62
SP  - 51
VL  - 164
DO  - 10.1016/j.matchemphys.2015.08.022
ER  - 
@article{
author = "Vuković, Jovana and Babić, Marija and Antić, Katarina and Miljković, Miona and Perić-Grujić, Aleksandra and Filipović, Jovanka M. and Tomić, Simonida",
year = "2015",
abstract = "In this study, three series of hydrogels based on 2-hydroxyethyl acrylate and itaconic acid, unloaded, with incorporated copper(II) ions and reduced copper, were successfully prepared, characterized and evaluated as novel wound healing materials. Fourier transform infrared spectroscopy (FTIR) confirmed the expected structure of obtained hydrogels. Scanning electron microscopy (SEM) revealed porous morphology of unloaded hydrogels, and the morphological modifications in case of loaded hydrogels. Thermal characteristics were examined by differential scanning calorimetry (DSC) and the glass transition temperatures were observed in range of 12-50 degrees C. Swelling study was conducted in wide range of pHs at 37 degrees C, confirming pH sensitive behaviour for all three series of hydrogels. The in vitro copper release was investigated and the experimental data were analysed using several models in order to elucidate the transport mechanism. The antimicrobial assay revealed excellent antimicrobial activity, over 99% against Escherichia coli, Staphylococcus aureus and Candida albicans, as well as good correlation with the copper release experiments. In accordance with potential application, water vapour transmission rate, oxygen penetration, dispersion characteristics, fluid retention were observed and the suitability of the hydrogels for wound healing application was discussed.",
publisher = "Elsevier Science Sa, Lausanne",
journal = "Materials Chemistry and Physics",
title = "A high efficacy antimicrobial acrylate based hydrogels with incorporated copper for wound healing application",
pages = "62-51",
volume = "164",
doi = "10.1016/j.matchemphys.2015.08.022"
}
Vuković, J., Babić, M., Antić, K., Miljković, M., Perić-Grujić, A., Filipović, J. M.,& Tomić, S.. (2015). A high efficacy antimicrobial acrylate based hydrogels with incorporated copper for wound healing application. in Materials Chemistry and Physics
Elsevier Science Sa, Lausanne., 164, 51-62.
https://doi.org/10.1016/j.matchemphys.2015.08.022
Vuković J, Babić M, Antić K, Miljković M, Perić-Grujić A, Filipović JM, Tomić S. A high efficacy antimicrobial acrylate based hydrogels with incorporated copper for wound healing application. in Materials Chemistry and Physics. 2015;164:51-62.
doi:10.1016/j.matchemphys.2015.08.022 .
Vuković, Jovana, Babić, Marija, Antić, Katarina, Miljković, Miona, Perić-Grujić, Aleksandra, Filipović, Jovanka M., Tomić, Simonida, "A high efficacy antimicrobial acrylate based hydrogels with incorporated copper for wound healing application" in Materials Chemistry and Physics, 164 (2015):51-62,
https://doi.org/10.1016/j.matchemphys.2015.08.022 . .

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