A high efficacy antimicrobial acrylate based hydrogels with incorporated copper for wound healing application
Samo za registrovane korisnike
2015
Autori
Vuković, Jovana
Babić, Marija

Antić, Katarina

Miljković, Miona

Perić-Grujić, Aleksandra

Filipović, Jovanka M.
Tomić, Simonida

Članak u časopisu (Objavljena verzija)

Metapodaci
Prikaz svih podataka o dokumentuApstrakt
In this study, three series of hydrogels based on 2-hydroxyethyl acrylate and itaconic acid, unloaded, with incorporated copper(II) ions and reduced copper, were successfully prepared, characterized and evaluated as novel wound healing materials. Fourier transform infrared spectroscopy (FTIR) confirmed the expected structure of obtained hydrogels. Scanning electron microscopy (SEM) revealed porous morphology of unloaded hydrogels, and the morphological modifications in case of loaded hydrogels. Thermal characteristics were examined by differential scanning calorimetry (DSC) and the glass transition temperatures were observed in range of 12-50 degrees C. Swelling study was conducted in wide range of pHs at 37 degrees C, confirming pH sensitive behaviour for all three series of hydrogels. The in vitro copper release was investigated and the experimental data were analysed using several models in order to elucidate the transport mechanism. The antimicrobial assay revealed excellent antimi...crobial activity, over 99% against Escherichia coli, Staphylococcus aureus and Candida albicans, as well as good correlation with the copper release experiments. In accordance with potential application, water vapour transmission rate, oxygen penetration, dispersion characteristics, fluid retention were observed and the suitability of the hydrogels for wound healing application was discussed.
Ključne reči:
Polymers / Thermal properties / Transport properties / BiomaterialsIzvor:
Materials Chemistry and Physics, 2015, 164, 51-62Izdavač:
- Elsevier Science Sa, Lausanne
Finansiranje / projekti:
- Sinteza i karakterizacija novih funkcionalnih polimera i polimernih nanokompozita (RS-172062)
- Hemijsko i strukturno dizajniranje nanomaterijala za primenu u medicini i inženjerstvu tkiva (RS-172026)
DOI: 10.1016/j.matchemphys.2015.08.022
ISSN: 0254-0584
WoS: 000362144800008
Scopus: 2-s2.0-84941413164
Kolekcije
Institucija/grupa
Tehnološko-metalurški fakultetTY - JOUR AU - Vuković, Jovana AU - Babić, Marija AU - Antić, Katarina AU - Miljković, Miona AU - Perić-Grujić, Aleksandra AU - Filipović, Jovanka M. AU - Tomić, Simonida PY - 2015 UR - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/3139 AB - In this study, three series of hydrogels based on 2-hydroxyethyl acrylate and itaconic acid, unloaded, with incorporated copper(II) ions and reduced copper, were successfully prepared, characterized and evaluated as novel wound healing materials. Fourier transform infrared spectroscopy (FTIR) confirmed the expected structure of obtained hydrogels. Scanning electron microscopy (SEM) revealed porous morphology of unloaded hydrogels, and the morphological modifications in case of loaded hydrogels. Thermal characteristics were examined by differential scanning calorimetry (DSC) and the glass transition temperatures were observed in range of 12-50 degrees C. Swelling study was conducted in wide range of pHs at 37 degrees C, confirming pH sensitive behaviour for all three series of hydrogels. The in vitro copper release was investigated and the experimental data were analysed using several models in order to elucidate the transport mechanism. The antimicrobial assay revealed excellent antimicrobial activity, over 99% against Escherichia coli, Staphylococcus aureus and Candida albicans, as well as good correlation with the copper release experiments. In accordance with potential application, water vapour transmission rate, oxygen penetration, dispersion characteristics, fluid retention were observed and the suitability of the hydrogels for wound healing application was discussed. PB - Elsevier Science Sa, Lausanne T2 - Materials Chemistry and Physics T1 - A high efficacy antimicrobial acrylate based hydrogels with incorporated copper for wound healing application EP - 62 SP - 51 VL - 164 DO - 10.1016/j.matchemphys.2015.08.022 ER -
@article{ author = "Vuković, Jovana and Babić, Marija and Antić, Katarina and Miljković, Miona and Perić-Grujić, Aleksandra and Filipović, Jovanka M. and Tomić, Simonida", year = "2015", abstract = "In this study, three series of hydrogels based on 2-hydroxyethyl acrylate and itaconic acid, unloaded, with incorporated copper(II) ions and reduced copper, were successfully prepared, characterized and evaluated as novel wound healing materials. Fourier transform infrared spectroscopy (FTIR) confirmed the expected structure of obtained hydrogels. Scanning electron microscopy (SEM) revealed porous morphology of unloaded hydrogels, and the morphological modifications in case of loaded hydrogels. Thermal characteristics were examined by differential scanning calorimetry (DSC) and the glass transition temperatures were observed in range of 12-50 degrees C. Swelling study was conducted in wide range of pHs at 37 degrees C, confirming pH sensitive behaviour for all three series of hydrogels. The in vitro copper release was investigated and the experimental data were analysed using several models in order to elucidate the transport mechanism. The antimicrobial assay revealed excellent antimicrobial activity, over 99% against Escherichia coli, Staphylococcus aureus and Candida albicans, as well as good correlation with the copper release experiments. In accordance with potential application, water vapour transmission rate, oxygen penetration, dispersion characteristics, fluid retention were observed and the suitability of the hydrogels for wound healing application was discussed.", publisher = "Elsevier Science Sa, Lausanne", journal = "Materials Chemistry and Physics", title = "A high efficacy antimicrobial acrylate based hydrogels with incorporated copper for wound healing application", pages = "62-51", volume = "164", doi = "10.1016/j.matchemphys.2015.08.022" }
Vuković, J., Babić, M., Antić, K., Miljković, M., Perić-Grujić, A., Filipović, J. M.,& Tomić, S.. (2015). A high efficacy antimicrobial acrylate based hydrogels with incorporated copper for wound healing application. in Materials Chemistry and Physics Elsevier Science Sa, Lausanne., 164, 51-62. https://doi.org/10.1016/j.matchemphys.2015.08.022
Vuković J, Babić M, Antić K, Miljković M, Perić-Grujić A, Filipović JM, Tomić S. A high efficacy antimicrobial acrylate based hydrogels with incorporated copper for wound healing application. in Materials Chemistry and Physics. 2015;164:51-62. doi:10.1016/j.matchemphys.2015.08.022 .
Vuković, Jovana, Babić, Marija, Antić, Katarina, Miljković, Miona, Perić-Grujić, Aleksandra, Filipović, Jovanka M., Tomić, Simonida, "A high efficacy antimicrobial acrylate based hydrogels with incorporated copper for wound healing application" in Materials Chemistry and Physics, 164 (2015):51-62, https://doi.org/10.1016/j.matchemphys.2015.08.022 . .