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dc.creatorVuković, Jovana
dc.creatorBabić, Marija
dc.creatorAntić, Katarina
dc.creatorMiljković, Miona
dc.creatorPerić-Grujić, Aleksandra
dc.creatorFilipović, Jovanka M.
dc.creatorTomić, Simonida
dc.date.accessioned2021-03-10T12:54:50Z
dc.date.available2021-03-10T12:54:50Z
dc.date.issued2015
dc.identifier.issn0254-0584
dc.identifier.urihttp://TechnoRep.tmf.bg.ac.rs/handle/123456789/3139
dc.description.abstractIn this study, three series of hydrogels based on 2-hydroxyethyl acrylate and itaconic acid, unloaded, with incorporated copper(II) ions and reduced copper, were successfully prepared, characterized and evaluated as novel wound healing materials. Fourier transform infrared spectroscopy (FTIR) confirmed the expected structure of obtained hydrogels. Scanning electron microscopy (SEM) revealed porous morphology of unloaded hydrogels, and the morphological modifications in case of loaded hydrogels. Thermal characteristics were examined by differential scanning calorimetry (DSC) and the glass transition temperatures were observed in range of 12-50 degrees C. Swelling study was conducted in wide range of pHs at 37 degrees C, confirming pH sensitive behaviour for all three series of hydrogels. The in vitro copper release was investigated and the experimental data were analysed using several models in order to elucidate the transport mechanism. The antimicrobial assay revealed excellent antimicrobial activity, over 99% against Escherichia coli, Staphylococcus aureus and Candida albicans, as well as good correlation with the copper release experiments. In accordance with potential application, water vapour transmission rate, oxygen penetration, dispersion characteristics, fluid retention were observed and the suitability of the hydrogels for wound healing application was discussed.en
dc.publisherElsevier Science Sa, Lausanne
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172062/RS//
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172026/RS//
dc.rightsrestrictedAccess
dc.sourceMaterials Chemistry and Physics
dc.subjectPolymersen
dc.subjectThermal propertiesen
dc.subjectTransport propertiesen
dc.subjectBiomaterialsen
dc.titleA high efficacy antimicrobial acrylate based hydrogels with incorporated copper for wound healing applicationen
dc.typearticle
dc.rights.licenseARR
dc.citation.epage62
dc.citation.other164: 51-62
dc.citation.rankM22
dc.citation.spage51
dc.citation.volume164
dc.identifier.doi10.1016/j.matchemphys.2015.08.022
dc.identifier.scopus2-s2.0-84941413164
dc.identifier.wos000362144800008
dc.type.versionpublishedVersion


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