Micro-environmentally restricted cell growth dynamics - modeling considerations
Само за регистроване кориснике
2015
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
Various modeling approaches have been applied to describe the rearrangement of immobilized cell clusters within the extracellular matrix. The cell rearrangement has been related with the micro-environmental restrictions to cell growth. Herein, an attempt is made to discuss and connect various modeling approaches on various time scales which have been proposed in the literature in order to shed further light to this complex phenomenon which induces micro-environmental restrictions to cell growth. The rearrangement is driven by internal stress generated within the cluster. The internal stress represents a consequence of the matrix rheological response to cell expansion. The rearrangement includes the interplay between the processes of: (1) single and collective cell migrations, (2) cell deformation and orientation, (3) decrease of cell-to-cell separation distances and (4) cell growth. It has been considered on two time scales: a short time scale (i.e. the rearrangement time) and a long t...ime scale (i.e. the growing time). The results indicate that short and long times cell rearrangement induces energy dissipation. The dissipation provokes biological responses of cells which cause the resistance effects to cell growth. Deeper insight in the anomalous nature of the energy dissipation would be useful for understanding the biological mechanisms which causes the resistance effects to cell growth.
Кључне речи:
Cell rearrangement / extracellular matrix / immobilized cell cluster / internal stress / mathematical modelingИзвор:
Critical Reviews in Biotechnology, 2015, 35, 3, 402-409Издавач:
- Taylor & Francis Ltd, Abingdon
Финансирање / пројекти:
- Развој нових инкапсулационих и ензимских технологија за производњу биокатализатора и биолошки активних компонената хране у циљу повећања њене конкурентности, квалитета и безбедности (RS-MESTD-Integrated and Interdisciplinary Research (IIR or III)-46010)
- Развој и примена нових и традиционалних технологија у производњи конкурентних прехрамбених производа са додатом вредношћу за европско и светско тржиште - Створимо богатство из богатства Србије (RS-MESTD-Integrated and Interdisciplinary Research (IIR or III)-46001)
DOI: 10.3109/07388551.2014.889078
ISSN: 0738-8551
PubMed: 24641483
WoS: 000361319400011
Scopus: 2-s2.0-84954210218
Институција/група
Tehnološko-metalurški fakultetTY - JOUR AU - Pajić-Lijaković, Ivana PY - 2015 UR - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/3147 AB - Various modeling approaches have been applied to describe the rearrangement of immobilized cell clusters within the extracellular matrix. The cell rearrangement has been related with the micro-environmental restrictions to cell growth. Herein, an attempt is made to discuss and connect various modeling approaches on various time scales which have been proposed in the literature in order to shed further light to this complex phenomenon which induces micro-environmental restrictions to cell growth. The rearrangement is driven by internal stress generated within the cluster. The internal stress represents a consequence of the matrix rheological response to cell expansion. The rearrangement includes the interplay between the processes of: (1) single and collective cell migrations, (2) cell deformation and orientation, (3) decrease of cell-to-cell separation distances and (4) cell growth. It has been considered on two time scales: a short time scale (i.e. the rearrangement time) and a long time scale (i.e. the growing time). The results indicate that short and long times cell rearrangement induces energy dissipation. The dissipation provokes biological responses of cells which cause the resistance effects to cell growth. Deeper insight in the anomalous nature of the energy dissipation would be useful for understanding the biological mechanisms which causes the resistance effects to cell growth. PB - Taylor & Francis Ltd, Abingdon T2 - Critical Reviews in Biotechnology T1 - Micro-environmentally restricted cell growth dynamics - modeling considerations EP - 409 IS - 3 SP - 402 VL - 35 DO - 10.3109/07388551.2014.889078 ER -
@article{ author = "Pajić-Lijaković, Ivana", year = "2015", abstract = "Various modeling approaches have been applied to describe the rearrangement of immobilized cell clusters within the extracellular matrix. The cell rearrangement has been related with the micro-environmental restrictions to cell growth. Herein, an attempt is made to discuss and connect various modeling approaches on various time scales which have been proposed in the literature in order to shed further light to this complex phenomenon which induces micro-environmental restrictions to cell growth. The rearrangement is driven by internal stress generated within the cluster. The internal stress represents a consequence of the matrix rheological response to cell expansion. The rearrangement includes the interplay between the processes of: (1) single and collective cell migrations, (2) cell deformation and orientation, (3) decrease of cell-to-cell separation distances and (4) cell growth. It has been considered on two time scales: a short time scale (i.e. the rearrangement time) and a long time scale (i.e. the growing time). The results indicate that short and long times cell rearrangement induces energy dissipation. The dissipation provokes biological responses of cells which cause the resistance effects to cell growth. Deeper insight in the anomalous nature of the energy dissipation would be useful for understanding the biological mechanisms which causes the resistance effects to cell growth.", publisher = "Taylor & Francis Ltd, Abingdon", journal = "Critical Reviews in Biotechnology", title = "Micro-environmentally restricted cell growth dynamics - modeling considerations", pages = "409-402", number = "3", volume = "35", doi = "10.3109/07388551.2014.889078" }
Pajić-Lijaković, I.. (2015). Micro-environmentally restricted cell growth dynamics - modeling considerations. in Critical Reviews in Biotechnology Taylor & Francis Ltd, Abingdon., 35(3), 402-409. https://doi.org/10.3109/07388551.2014.889078
Pajić-Lijaković I. Micro-environmentally restricted cell growth dynamics - modeling considerations. in Critical Reviews in Biotechnology. 2015;35(3):402-409. doi:10.3109/07388551.2014.889078 .
Pajić-Lijaković, Ivana, "Micro-environmentally restricted cell growth dynamics - modeling considerations" in Critical Reviews in Biotechnology, 35, no. 3 (2015):402-409, https://doi.org/10.3109/07388551.2014.889078 . .