Investigation of electrochemical behavior of anisomycin on gold electrode followed by HPLC-MS/MS analysis
2015
Autori
Tolić, LjiljanaLović, Jelena
Petrović, Slobodan
Mijin, Dušan
Grujić, Svetlana
Laušević, Mila
Avramov-Ivić, Milka
Članak u časopisu (Objavljena verzija)
Metapodaci
Prikaz svih podataka o dokumentuApstrakt
Anisomycin is an immunosuppressant in low doses ( lt 0.1 mu M) with possible application in treatment of some autoimmune diseases and in inhibiting transplantation rejection. Anisomycin suppresses malignant tumor cell growth and affects memory. For the first time it was the subject of the electrochemical investigations by cyclic voltammetry and square wave voltammetry on gold electrode in 0.05 M NaHCO3 using its electrochemical activity. The cyclic voltammetry experiments at different sweep rates show that electrochemical process is irreversible and diffusion controlled. Based on square wave voltammetry measurements, the calculated values of LOD and LOQ were 1 and 4 nM (in the absence of biological fluid), as well as 2 and 6 nM (in the presence of spiked urine) indicating the high sensitivity of the proposed electroanalytical method. High performance liquid chromatography-tandem mass spectrometry was a reference method for quantification of anisomycin and served for structural identifi...cation of its hydrolysis product (deacetylanisomycin).
Ključne reči:
Anisomycin / Electroactivity / SWV / HPLC-MS/MSIzvor:
Electrochemistry Communications, 2015, 58, 20-24Izdavač:
- Elsevier Science Inc, New York
Finansiranje / projekti:
- Proučavanje sinteze, strukture i aktivnosti organskih jedinjenja prirodnog i sintetskog porekla (RS-172013)
- Nov pristup dizajniranju materijala za konverziju i skladištenje energije (RS-172060)
- Razvoj i primena metoda i materijala za monitoring novih zagađujućih i toksičnih organskih materija i teških metala (RS-172007)
DOI: 10.1016/j.elecom.2015.05.017
ISSN: 1388-2481
WoS: 000360514600005
Scopus: 2-s2.0-84934888024
Kolekcije
Institucija/grupa
Tehnološko-metalurški fakultetTY - JOUR AU - Tolić, Ljiljana AU - Lović, Jelena AU - Petrović, Slobodan AU - Mijin, Dušan AU - Grujić, Svetlana AU - Laušević, Mila AU - Avramov-Ivić, Milka PY - 2015 UR - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/3148 AB - Anisomycin is an immunosuppressant in low doses ( lt 0.1 mu M) with possible application in treatment of some autoimmune diseases and in inhibiting transplantation rejection. Anisomycin suppresses malignant tumor cell growth and affects memory. For the first time it was the subject of the electrochemical investigations by cyclic voltammetry and square wave voltammetry on gold electrode in 0.05 M NaHCO3 using its electrochemical activity. The cyclic voltammetry experiments at different sweep rates show that electrochemical process is irreversible and diffusion controlled. Based on square wave voltammetry measurements, the calculated values of LOD and LOQ were 1 and 4 nM (in the absence of biological fluid), as well as 2 and 6 nM (in the presence of spiked urine) indicating the high sensitivity of the proposed electroanalytical method. High performance liquid chromatography-tandem mass spectrometry was a reference method for quantification of anisomycin and served for structural identification of its hydrolysis product (deacetylanisomycin). PB - Elsevier Science Inc, New York T2 - Electrochemistry Communications T1 - Investigation of electrochemical behavior of anisomycin on gold electrode followed by HPLC-MS/MS analysis EP - 24 SP - 20 VL - 58 DO - 10.1016/j.elecom.2015.05.017 ER -
@article{ author = "Tolić, Ljiljana and Lović, Jelena and Petrović, Slobodan and Mijin, Dušan and Grujić, Svetlana and Laušević, Mila and Avramov-Ivić, Milka", year = "2015", abstract = "Anisomycin is an immunosuppressant in low doses ( lt 0.1 mu M) with possible application in treatment of some autoimmune diseases and in inhibiting transplantation rejection. Anisomycin suppresses malignant tumor cell growth and affects memory. For the first time it was the subject of the electrochemical investigations by cyclic voltammetry and square wave voltammetry on gold electrode in 0.05 M NaHCO3 using its electrochemical activity. The cyclic voltammetry experiments at different sweep rates show that electrochemical process is irreversible and diffusion controlled. Based on square wave voltammetry measurements, the calculated values of LOD and LOQ were 1 and 4 nM (in the absence of biological fluid), as well as 2 and 6 nM (in the presence of spiked urine) indicating the high sensitivity of the proposed electroanalytical method. High performance liquid chromatography-tandem mass spectrometry was a reference method for quantification of anisomycin and served for structural identification of its hydrolysis product (deacetylanisomycin).", publisher = "Elsevier Science Inc, New York", journal = "Electrochemistry Communications", title = "Investigation of electrochemical behavior of anisomycin on gold electrode followed by HPLC-MS/MS analysis", pages = "24-20", volume = "58", doi = "10.1016/j.elecom.2015.05.017" }
Tolić, L., Lović, J., Petrović, S., Mijin, D., Grujić, S., Laušević, M.,& Avramov-Ivić, M.. (2015). Investigation of electrochemical behavior of anisomycin on gold electrode followed by HPLC-MS/MS analysis. in Electrochemistry Communications Elsevier Science Inc, New York., 58, 20-24. https://doi.org/10.1016/j.elecom.2015.05.017
Tolić L, Lović J, Petrović S, Mijin D, Grujić S, Laušević M, Avramov-Ivić M. Investigation of electrochemical behavior of anisomycin on gold electrode followed by HPLC-MS/MS analysis. in Electrochemistry Communications. 2015;58:20-24. doi:10.1016/j.elecom.2015.05.017 .
Tolić, Ljiljana, Lović, Jelena, Petrović, Slobodan, Mijin, Dušan, Grujić, Svetlana, Laušević, Mila, Avramov-Ivić, Milka, "Investigation of electrochemical behavior of anisomycin on gold electrode followed by HPLC-MS/MS analysis" in Electrochemistry Communications, 58 (2015):20-24, https://doi.org/10.1016/j.elecom.2015.05.017 . .