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dc.creatorTakić-Miladinov, Dijana
dc.creatorTomić, Simonida
dc.creatorStojanović, Sanja T.
dc.creatorNajdanović, Jelena
dc.creatorFilipović, Jovanka
dc.creatorTrajanović, Miroslav
dc.creatorNajman, Stevo
dc.date.accessioned2021-03-10T13:05:42Z
dc.date.available2021-03-10T13:05:42Z
dc.date.issued2016
dc.identifier.issn1516-1439
dc.identifier.urihttp://TechnoRep.tmf.bg.ac.rs/handle/123456789/3307
dc.description.abstractIn this study we prepared hydrogels based on 2-hydroxyethyl methacrylate (HEMA): PHEMA homopolymer and two terpolymers of HEMA, itaconic acid (IA) and two poly(alkylene glycol) (meth) acrylates (PAGM): poly(ethylene glycol)(6) acrylate (P(HEMA/IA/PAGM1)) and poly(propylene glycol)(5) methacrylate (P(HEMA/IA/PAGM2)). Hydrogels were synthesized by gamma-irradiated radical polymerization and subjected to swelling measurements and genotoxicity evaluation. Swelling studies confirmed that these hydrogels deserve consideration as biomaterials due to their ability to swell in phosphate buffer but maintaining physical integrity for a prolonged contact time after equilibrium state has been reached. Comet assay showed certain genotoxic effect following cell exposure to extracts of hydrogels, which was dependent on the concentration of extracts, chemical composition of hydrogels and the degree of crosslinking. The influence of concentration on genotoxicity was the most pronounced. The synthesis of these novel HEMA-based hydrogels should be optimized so as to reduce their toxicity and enable the use in clinical practice.en
dc.publisherUniversity of Fed Sao Carlos, Dept Engenharia Materials, Sao Carlos
dc.relationinfo:eu-repo/grantAgreement/MESTD/Integrated and Interdisciplinary Research (IIR or III)/41017/RS//
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172062/RS//
dc.rightsopenAccess
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.sourceMaterials Research-Ibero-American Journal of Materials
dc.subjectHEMA-based hydrogelsen
dc.subjectitaconic aciden
dc.subjectswellingen
dc.subjectgenotoxicityen
dc.subjectComet assayen
dc.titleSynthesis, Swelling Properties and Evaluation of Genotoxicity of Hydrogels Based on (Meth)acrylates and Itaconic Aciden
dc.typearticle
dc.rights.licenseBY
dc.citation.epage1079
dc.citation.issue5
dc.citation.other19(5): 1070-1079
dc.citation.rankM23
dc.citation.spage1070
dc.citation.volume19
dc.identifier.doi10.1590/1980-5373-MR-2016-0222
dc.identifier.fulltexthttp://TechnoRep.tmf.bg.ac.rs/bitstream/id/1234/3304.pdf
dc.identifier.scopus2-s2.0-84989872169
dc.identifier.wos000385626000014
dc.type.versionpublishedVersion


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Приказ основних података о документу