Приказ основних података о документу

dc.creatorElshaflu, Hana
dc.creatorBjelogrlić, Snežana K.
dc.creatorMuller, Christian D.
dc.creatorTodorović, Tamara
dc.creatorRodić, Marko
dc.creatorMarinković, Aleksandar
dc.creatorFilipović, Nenad R.
dc.date.accessioned2021-03-10T13:07:00Z
dc.date.available2021-03-10T13:07:00Z
dc.date.issued2016
dc.identifier.issn0095-8972
dc.identifier.urihttp://TechnoRep.tmf.bg.ac.rs/handle/123456789/3327
dc.description.abstractCo(III) complex with a 2-hydrazonylthiazole ligand was synthesized and characterized by single-crystal X-ray diffraction. In the inner sphere of the complex, two monoionic ligands are coordinated tridentately forming octahedral geometry around Co(III). Activity of the complex was investigated on MCF-7 breast cancer cell line, with cisplatin (CDDP) as a reference compound. Results showed that after 24-h incubation, Co(III) complex revealed stronger cytotoxic activity compared to CDDP. Treatment of MCF-7 3-D cell model with the complex at 10M concentration achieved complete suppression of spheroid growth in almost the same extent as at 100M. In combination treatments on MCF-7 spheroids, the complex acted synergistically with CDDP, while additive interaction type was achieved when the complex was applied together with paclitaxel. [GRAPHICS] .en
dc.publisherTaylor & Francis Ltd, Abingdon
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172055/RS//
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172013/RS//
dc.relation.isversionofhttps://technorep.tmf.bg.ac.rs/handle/123456789/4721
dc.rightsrestrictedAccess
dc.sourceJournal of Coordination Chemistry
dc.subjectThiazolesen
dc.subjectCo(III) complexen
dc.subjectX-ray diffractionen
dc.subjectanticancer activityen
dc.subjectthree-drug combination studyen
dc.titleCo(III) complex with (E)-2-(2-(pyridine-2-ylmethylene)hydrazinyl)-4-(4-tolyl)-1,3-thiazole: structure and activity against 2-D and 3-D cancer cell modelsen
dc.typearticle
dc.rights.licenseARR
dc.citation.epage3366
dc.citation.issue22
dc.citation.other69(22): 3354-3366
dc.citation.rankM22
dc.citation.spage3354
dc.citation.volume69
dc.description.otherPeer-reviewed manuscript: [http://technorep.tmf.bg.ac.rs/handle/123456789/4721]
dc.identifier.doi10.1080/00958972.2016.1232404
dc.identifier.scopus2-s2.0-84988615513
dc.identifier.wos000386021200005
dc.type.versionpublishedVersion


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Приказ основних података о документу