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dc.creatorDrvenica, Ivana
dc.creatorBukara, Katarina
dc.creatorIlić, Vesna Lj.
dc.creatorMišić, Danijela
dc.creatorVasić, Borislav
dc.creatorGajić, Radoš B.
dc.creatorĐorđević, Verica
dc.creatorVeljović, Đorđe
dc.creatorBelić, Aleksandar
dc.creatorBugarski, Branko
dc.date.accessioned2021-03-10T13:07:08Z
dc.date.available2021-03-10T13:07:08Z
dc.date.issued2016
dc.identifier.issn8756-7938
dc.identifier.urihttp://TechnoRep.tmf.bg.ac.rs/handle/123456789/3329
dc.description.abstractThe present study investigated preparation of bovine and porcine erythrocyte membranes from slaughterhouse blood as bio-derived materials for delivery of dexamethasone-sodium phosphate (DexP). The obtained biomembranes, i.e., ghosts were characterized in vitro in terms of morphological properties, loading parameters, and release behavior. For the last two, an UHPLC/-HESI-MS/MS based analytical procedure for absolute drug identification and quantification was developed. The results revealed that loading of DexP into both type of ghosts was directly proportional to the increase of drug concentration in the incubation medium, while incubation at 37 degrees C had statistically significant effect on loaded amount of DexP (P lt 0.05). The encapsulation efficiency was about fivefold higher in porcine compared to bovine ghosts. Insight into ghosts' surface morphology by field emission-scanning electron microscopy and atomic force microscopy confirmed that besides inevitable effects of osmosis, DexP inclusion itself had no observable additional effect on the morphology of the ghosts carriers. DexP release profiles were dependent on erythrocyte ghost type and amount of residual hemoglobin. However, sustained DexP release was achieved and shown over 3 days from porcine ghosts and 5 days from bovine erythrocyte ghosts.en
dc.publisherWiley, Hoboken
dc.relationinfo:eu-repo/grantAgreement/MESTD/Integrated and Interdisciplinary Research (IIR or III)/46010/RS//
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/171005/RS//
dc.rightsopenAccess
dc.sourceBiotechnology Progress
dc.subjectbiomembranesen
dc.subjecterythrocyte ghostsen
dc.subjectslaughterhouse blooden
dc.subjectdexamethasone sodium phosphateen
dc.subjectdrug delivery systemsen
dc.titleBiomembranes from slaughterhouse blood erythrocytes as prolonged release systems for dexamethasone sodium phosphateen
dc.typearticle
dc.rights.licenseARR
dc.citation.epage1055
dc.citation.issue4
dc.citation.other32(4): 1046-1055
dc.citation.rankM22
dc.citation.spage1046
dc.citation.volume32
dc.identifier.doi10.1002/btpr.2304
dc.identifier.fulltexthttp://TechnoRep.tmf.bg.ac.rs/bitstream/id/1253/3326.pdf
dc.identifier.pmid27254304
dc.identifier.scopus2-s2.0-85027919097
dc.identifier.wos000383396800024
dc.type.versionpublishedVersion


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Приказ основних података о документу