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dc.creatorVuković, Jovana
dc.creatorBabić, Marija
dc.creatorAntić, Katarina
dc.creatorFilipović, Jovanka M.
dc.creatorStojanović, Sanja T.
dc.creatorNajman, Stevo
dc.creatorTomić, Simonida
dc.date.accessioned2021-03-10T13:08:38Z
dc.date.available2021-03-10T13:08:38Z
dc.date.issued2016
dc.identifier.issn0254-0584
dc.identifier.urihttp://TechnoRep.tmf.bg.ac.rs/handle/123456789/3352
dc.description.abstractIn order to evaluate biological response and potential toxicity prior to clinical use as wound dressing materials, three series of hydrogels, based on 2-hydroxyethyl acrylate (HEA) and itaconic acid (IA), unloaded, with incorporated copper(II) ions and reduced copper, were subjected to cytotoxicity testing on L929 cell line (mouse fibroblasts). MTT test revealed proper fibroblast growth in the presence of tested hydrogels, with an absence of any acute toxic effects. Mechanical properties of all three hydrogel series were studied by dynamic mechanical analysis (DMA) and obtained results indicated dominant elastic over viscous behaviour, which supports their application in wound management. The temperature sensitive behaviour of the hydrogels was detected in swelling study conducted in wide range of temperature values 25-50 degrees C, in buffer pH 7.40. The hydrogels exhibited excellent microbial barrier characteristics against Pseudomonas aeruginosa, reducing the risk of bacterial infection in wound bed.en
dc.publisherElsevier Science Sa, Lausanne
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172062/RS//
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172026/RS//
dc.rightsrestrictedAccess
dc.sourceMaterials Chemistry and Physics
dc.subjectPolymersen
dc.subjectMechanical propertiesen
dc.subjectTransport propertiesen
dc.subjectBiomaterialsen
dc.titleIn vitro cytotoxicity assessment of intelligent acrylate based hydrogels with incorporated copper in wound managementen
dc.typearticle
dc.rights.licenseARR
dc.citation.epage163
dc.citation.other175: 158-163
dc.citation.rankM22
dc.citation.spage158
dc.citation.volume175
dc.identifier.doi10.1016/j.matchemphys.2016.03.009
dc.identifier.rcubconv_4977
dc.identifier.scopus2-s2.0-84977934865
dc.identifier.wos000374612000020
dc.type.versionpublishedVersion


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