A Chemometrical Analysis of Voltammetric Data for Simultaneous Determination of Phenobarbital Sodium and Paracetamol Obtained at a Gold Electrode

2016
Authors
Avramov-Ivić, Milka
Antanasijević, Jelena
Trišović, Nemanja

Antanasijević, Davor

Lović, Jelena

Mijin, Dušan

Petrović, Slobodan
Article (Published version)

Metadata
Show full item recordAbstract
The electrochemical behavior of phenobarbital sodium (PBS), paracetamol (PCM) and their binary mixtures was investigated using cyclic voltammetry (CV) and square wave voltammetry (SWV) at a bare gold electrode in a 0.05 M bicarbonate solution. A calibration curve of PBS obtained by SWV had two linear ranges, from 1.0 to 3.0 mu M and from 5.0 to 35.0 mu M with a limit of quantification (LOQ) of 0.62 mu M and a limit of detection (LOD) of 0.19 mu M, while a calibration curve of PCM was determined within the range from 10.0 to 50.0 mu M with a LOQ of 8.53 mu M and a LOD of 2.56 mu M. Both drugs underwent oxidation by irreversible, diffusion controlled process. The SW voltammograms of the drug mixtures produced complex, overlapping profiles and a chemometric method was applied for their decomposition. Two different artificial neural network (ANN) architectures, namely back-propagation neural network (BPNN) and general regression neural network (GRNN) were employed for the simultaneous pred...iction of the concentrations of the drugs in a synthetic sample. The BPNN model had higher accuracy (mean absolute percentage error values were in the range of 3.6-8.4%) and thus it can be used for the simultaneous determination of PBS and PCM.
Keywords:
phenobarbital / paracetamol / voltammetry / chemometricsSource:
International Journal of Electrochemical Science, 2016, 11, 7, 5935-5951Publisher:
- Electrochemical Science Group, Beograd
Funding / projects:
- Study of the Synthesis, Structure and Activity of Natural and Synthetic Organic Compounds (RS-172013)
- New approach in designing materials for energy conversion and energy storage systems (RS-172060)
- Development and Application of Methods and Materials for Monitoring New Organic Contaminants, Toxic Compounds and Heavy Metals (RS-172007)
DOI: 10.20964/2016.07.48
ISSN: 1452-3981
WoS: 000384905600050
Scopus: 2-s2.0-84978138152
Institution/Community
Tehnološko-metalurški fakultetTY - JOUR AU - Avramov-Ivić, Milka AU - Antanasijević, Jelena AU - Trišović, Nemanja AU - Antanasijević, Davor AU - Lović, Jelena AU - Mijin, Dušan AU - Petrović, Slobodan PY - 2016 UR - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/3358 AB - The electrochemical behavior of phenobarbital sodium (PBS), paracetamol (PCM) and their binary mixtures was investigated using cyclic voltammetry (CV) and square wave voltammetry (SWV) at a bare gold electrode in a 0.05 M bicarbonate solution. A calibration curve of PBS obtained by SWV had two linear ranges, from 1.0 to 3.0 mu M and from 5.0 to 35.0 mu M with a limit of quantification (LOQ) of 0.62 mu M and a limit of detection (LOD) of 0.19 mu M, while a calibration curve of PCM was determined within the range from 10.0 to 50.0 mu M with a LOQ of 8.53 mu M and a LOD of 2.56 mu M. Both drugs underwent oxidation by irreversible, diffusion controlled process. The SW voltammograms of the drug mixtures produced complex, overlapping profiles and a chemometric method was applied for their decomposition. Two different artificial neural network (ANN) architectures, namely back-propagation neural network (BPNN) and general regression neural network (GRNN) were employed for the simultaneous prediction of the concentrations of the drugs in a synthetic sample. The BPNN model had higher accuracy (mean absolute percentage error values were in the range of 3.6-8.4%) and thus it can be used for the simultaneous determination of PBS and PCM. PB - Electrochemical Science Group, Beograd T2 - International Journal of Electrochemical Science T1 - A Chemometrical Analysis of Voltammetric Data for Simultaneous Determination of Phenobarbital Sodium and Paracetamol Obtained at a Gold Electrode EP - 5951 IS - 7 SP - 5935 VL - 11 DO - 10.20964/2016.07.48 ER -
@article{ author = "Avramov-Ivić, Milka and Antanasijević, Jelena and Trišović, Nemanja and Antanasijević, Davor and Lović, Jelena and Mijin, Dušan and Petrović, Slobodan", year = "2016", abstract = "The electrochemical behavior of phenobarbital sodium (PBS), paracetamol (PCM) and their binary mixtures was investigated using cyclic voltammetry (CV) and square wave voltammetry (SWV) at a bare gold electrode in a 0.05 M bicarbonate solution. A calibration curve of PBS obtained by SWV had two linear ranges, from 1.0 to 3.0 mu M and from 5.0 to 35.0 mu M with a limit of quantification (LOQ) of 0.62 mu M and a limit of detection (LOD) of 0.19 mu M, while a calibration curve of PCM was determined within the range from 10.0 to 50.0 mu M with a LOQ of 8.53 mu M and a LOD of 2.56 mu M. Both drugs underwent oxidation by irreversible, diffusion controlled process. The SW voltammograms of the drug mixtures produced complex, overlapping profiles and a chemometric method was applied for their decomposition. Two different artificial neural network (ANN) architectures, namely back-propagation neural network (BPNN) and general regression neural network (GRNN) were employed for the simultaneous prediction of the concentrations of the drugs in a synthetic sample. The BPNN model had higher accuracy (mean absolute percentage error values were in the range of 3.6-8.4%) and thus it can be used for the simultaneous determination of PBS and PCM.", publisher = "Electrochemical Science Group, Beograd", journal = "International Journal of Electrochemical Science", title = "A Chemometrical Analysis of Voltammetric Data for Simultaneous Determination of Phenobarbital Sodium and Paracetamol Obtained at a Gold Electrode", pages = "5951-5935", number = "7", volume = "11", doi = "10.20964/2016.07.48" }
Avramov-Ivić, M., Antanasijević, J., Trišović, N., Antanasijević, D., Lović, J., Mijin, D.,& Petrović, S.. (2016). A Chemometrical Analysis of Voltammetric Data for Simultaneous Determination of Phenobarbital Sodium and Paracetamol Obtained at a Gold Electrode. in International Journal of Electrochemical Science Electrochemical Science Group, Beograd., 11(7), 5935-5951. https://doi.org/10.20964/2016.07.48
Avramov-Ivić M, Antanasijević J, Trišović N, Antanasijević D, Lović J, Mijin D, Petrović S. A Chemometrical Analysis of Voltammetric Data for Simultaneous Determination of Phenobarbital Sodium and Paracetamol Obtained at a Gold Electrode. in International Journal of Electrochemical Science. 2016;11(7):5935-5951. doi:10.20964/2016.07.48 .
Avramov-Ivić, Milka, Antanasijević, Jelena, Trišović, Nemanja, Antanasijević, Davor, Lović, Jelena, Mijin, Dušan, Petrović, Slobodan, "A Chemometrical Analysis of Voltammetric Data for Simultaneous Determination of Phenobarbital Sodium and Paracetamol Obtained at a Gold Electrode" in International Journal of Electrochemical Science, 11, no. 7 (2016):5935-5951, https://doi.org/10.20964/2016.07.48 . .