A Chemometrical Analysis of Voltammetric Data for Simultaneous Determination of Phenobarbital Sodium and Paracetamol Obtained at a Gold Electrode

2016
Authors
Avramov-Ivić, Milka
Antanasijević, Jelena
Trišović, Nemanja

Antanasijević, Davor

Lović, Jelena

Mijin, Dušan

Petrović, Slobodan
article (publishedVersion)

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Show full item recordAbstract
The electrochemical behavior of phenobarbital sodium (PBS), paracetamol (PCM) and their binary mixtures was investigated using cyclic voltammetry (CV) and square wave voltammetry (SWV) at a bare gold electrode in a 0.05 M bicarbonate solution. A calibration curve of PBS obtained by SWV had two linear ranges, from 1.0 to 3.0 mu M and from 5.0 to 35.0 mu M with a limit of quantification (LOQ) of 0.62 mu M and a limit of detection (LOD) of 0.19 mu M, while a calibration curve of PCM was determined within the range from 10.0 to 50.0 mu M with a LOQ of 8.53 mu M and a LOD of 2.56 mu M. Both drugs underwent oxidation by irreversible, diffusion controlled process. The SW voltammograms of the drug mixtures produced complex, overlapping profiles and a chemometric method was applied for their decomposition. Two different artificial neural network (ANN) architectures, namely back-propagation neural network (BPNN) and general regression neural network (GRNN) were employed for the simultaneous pred...iction of the concentrations of the drugs in a synthetic sample. The BPNN model had higher accuracy (mean absolute percentage error values were in the range of 3.6-8.4%) and thus it can be used for the simultaneous determination of PBS and PCM.
Keywords:
phenobarbital / paracetamol / voltammetry / chemometricsSource:
International Journal of Electrochemical Science, 2016, 11, 7, 5935-5951Publisher:
- Electrochemical Science Group, Beograd
Funding / projects:
- info:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172013/RS// (RS-172013)
- info:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172060/RS// (RS-172060)
- info:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172007/RS// (RS-172007)
DOI: 10.20964/2016.07.48
ISSN: 1452-3981