Upregulation of Heme Oxygenase-1 in Response to Wild Thyme Treatment Protects against Hypertension and Oxidative Stress
Autori
Mihailović-Stanojević, NevenaMiloradović, Zoran
Ivanov, Milan
Bugarski, Branko
Jovović, Đurđica
Karanović, Danijela
Vajić, Una-Jovana
Komes, Drazenka
Grujić-Milanović, Jelica
Članak u časopisu (Objavljena verzija)
Metapodaci
Prikaz svih podataka o dokumentuApstrakt
High blood pressure is the most powerful contributor to the cardiovascular morbidity and mortality, and inverse correlation between consumption of polyphenol-rich foods or beverages and incidence of cardiovascular diseases gains more importance. Reactive oxygen species plays an important role in the development of hypertension. We found that wild thyme (a spice plant, rich in polyphenolic compounds) induced a significant decrease of blood pressure and vascular resistance in hypertensive rats. The inverse correlation between vascular resistance and plasma heme oxygenase-1 suggests that endogenous vasodilator carbon monoxide generated by heme oxidation could account for this normalization of blood pressure. Next product of heme oxidation, bilirubin (a chain-breaking antioxidant that acts as a lipid peroxyl radical scavenger), becomes significantly increased after wild thyme treatment and induces the reduction of plasma lipid peroxidation in hypertensive, but not in normotensive rats. The... obtained results promote wild thyme as useful supplement for cardiovascular interventions.
Izvor:
Oxidative Medicine and Cellular Longevity, 2016, 2016Izdavač:
- Hindawi Ltd, London
Finansiranje / projekti:
- Razvoj novih inkapsulacionih i enzimskih tehnologija za proizvodnju biokatalizatora i biološki aktivnih komponenata hrane u cilju povećanja njene konkurentnosti, kvaliteta i bezbednosti (RS-MESTD-Integrated and Interdisciplinary Research (IIR or III)-46010)
DOI: 10.1155/2016/1458793
ISSN: 1942-0900
PubMed: 27774115
WoS: 000385101300001
Scopus: 2-s2.0-84991387659
Institucija/grupa
Tehnološko-metalurški fakultetTY - JOUR AU - Mihailović-Stanojević, Nevena AU - Miloradović, Zoran AU - Ivanov, Milan AU - Bugarski, Branko AU - Jovović, Đurđica AU - Karanović, Danijela AU - Vajić, Una-Jovana AU - Komes, Drazenka AU - Grujić-Milanović, Jelica PY - 2016 UR - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/3363 AB - High blood pressure is the most powerful contributor to the cardiovascular morbidity and mortality, and inverse correlation between consumption of polyphenol-rich foods or beverages and incidence of cardiovascular diseases gains more importance. Reactive oxygen species plays an important role in the development of hypertension. We found that wild thyme (a spice plant, rich in polyphenolic compounds) induced a significant decrease of blood pressure and vascular resistance in hypertensive rats. The inverse correlation between vascular resistance and plasma heme oxygenase-1 suggests that endogenous vasodilator carbon monoxide generated by heme oxidation could account for this normalization of blood pressure. Next product of heme oxidation, bilirubin (a chain-breaking antioxidant that acts as a lipid peroxyl radical scavenger), becomes significantly increased after wild thyme treatment and induces the reduction of plasma lipid peroxidation in hypertensive, but not in normotensive rats. The obtained results promote wild thyme as useful supplement for cardiovascular interventions. PB - Hindawi Ltd, London T2 - Oxidative Medicine and Cellular Longevity T1 - Upregulation of Heme Oxygenase-1 in Response to Wild Thyme Treatment Protects against Hypertension and Oxidative Stress VL - 2016 DO - 10.1155/2016/1458793 ER -
@article{ author = "Mihailović-Stanojević, Nevena and Miloradović, Zoran and Ivanov, Milan and Bugarski, Branko and Jovović, Đurđica and Karanović, Danijela and Vajić, Una-Jovana and Komes, Drazenka and Grujić-Milanović, Jelica", year = "2016", abstract = "High blood pressure is the most powerful contributor to the cardiovascular morbidity and mortality, and inverse correlation between consumption of polyphenol-rich foods or beverages and incidence of cardiovascular diseases gains more importance. Reactive oxygen species plays an important role in the development of hypertension. We found that wild thyme (a spice plant, rich in polyphenolic compounds) induced a significant decrease of blood pressure and vascular resistance in hypertensive rats. The inverse correlation between vascular resistance and plasma heme oxygenase-1 suggests that endogenous vasodilator carbon monoxide generated by heme oxidation could account for this normalization of blood pressure. Next product of heme oxidation, bilirubin (a chain-breaking antioxidant that acts as a lipid peroxyl radical scavenger), becomes significantly increased after wild thyme treatment and induces the reduction of plasma lipid peroxidation in hypertensive, but not in normotensive rats. The obtained results promote wild thyme as useful supplement for cardiovascular interventions.", publisher = "Hindawi Ltd, London", journal = "Oxidative Medicine and Cellular Longevity", title = "Upregulation of Heme Oxygenase-1 in Response to Wild Thyme Treatment Protects against Hypertension and Oxidative Stress", volume = "2016", doi = "10.1155/2016/1458793" }
Mihailović-Stanojević, N., Miloradović, Z., Ivanov, M., Bugarski, B., Jovović, Đ., Karanović, D., Vajić, U., Komes, D.,& Grujić-Milanović, J.. (2016). Upregulation of Heme Oxygenase-1 in Response to Wild Thyme Treatment Protects against Hypertension and Oxidative Stress. in Oxidative Medicine and Cellular Longevity Hindawi Ltd, London., 2016. https://doi.org/10.1155/2016/1458793
Mihailović-Stanojević N, Miloradović Z, Ivanov M, Bugarski B, Jovović Đ, Karanović D, Vajić U, Komes D, Grujić-Milanović J. Upregulation of Heme Oxygenase-1 in Response to Wild Thyme Treatment Protects against Hypertension and Oxidative Stress. in Oxidative Medicine and Cellular Longevity. 2016;2016. doi:10.1155/2016/1458793 .
Mihailović-Stanojević, Nevena, Miloradović, Zoran, Ivanov, Milan, Bugarski, Branko, Jovović, Đurđica, Karanović, Danijela, Vajić, Una-Jovana, Komes, Drazenka, Grujić-Milanović, Jelica, "Upregulation of Heme Oxygenase-1 in Response to Wild Thyme Treatment Protects against Hypertension and Oxidative Stress" in Oxidative Medicine and Cellular Longevity, 2016 (2016), https://doi.org/10.1155/2016/1458793 . .