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Hydroxylated fullerene-capped, vinblastine-loaded folic acid-functionalized mesoporous silica nanoparticles for targeted anticancer therapy
dc.creator | Knežević, Nikola Ž. | |
dc.creator | Mrdanović, Jasminka | |
dc.creator | Borisev, Ivana | |
dc.creator | Milenković, Sanja | |
dc.creator | Janaćković, Đorđe | |
dc.creator | Cunin, Frederique | |
dc.creator | Đorđević, Aleksandar | |
dc.date.accessioned | 2021-03-10T13:10:50Z | |
dc.date.available | 2021-03-10T13:10:50Z | |
dc.date.issued | 2016 | |
dc.identifier.issn | 2046-2069 | |
dc.identifier.uri | http://TechnoRep.tmf.bg.ac.rs/handle/123456789/3386 | |
dc.description.abstract | A novel cancer-targeting drug delivery system is constructed and characterized, based on folic acid-functionalized mesoporous silica nanoparticles with pore-loaded anticancer drug vinblastine and pore-blocking fullerenol molecules. The selective treatment efficacy based on targeting of cancer-verexpressed folate receptors is demonstrated by comparison of cell viability upon the treatment of healthy MRC-5, breast cancer MCF-7 and cervical cancer HeLa cells, which are known to differ in the amount of folate receptors on their surfaces. | en |
dc.publisher | Royal Society of Chemistry | |
dc.relation | info:eu-repo/grantAgreement/MESTD/Integrated and Interdisciplinary Research (IIR or III)/45005/RS// | |
dc.relation | info:eu-repo/grantAgreement/MESTD/Integrated and Interdisciplinary Research (IIR or III)/45019/RS// | |
dc.rights | openAccess | |
dc.rights.uri | https://creativecommons.org/licenses/by-nc/4.0/ | |
dc.source | RSC Advances | |
dc.title | Hydroxylated fullerene-capped, vinblastine-loaded folic acid-functionalized mesoporous silica nanoparticles for targeted anticancer therapy | en |
dc.type | article | |
dc.rights.license | BY-NC | |
dc.citation.epage | 7065 | |
dc.citation.issue | 9 | |
dc.citation.other | 6(9): 7061-7065 | |
dc.citation.rank | M22 | |
dc.citation.spage | 7061 | |
dc.citation.volume | 6 | |
dc.identifier.doi | 10.1039/c5ra22937e | |
dc.identifier.fulltext | http://TechnoRep.tmf.bg.ac.rs/bitstream/id/13116/c5ra22937e.pdf | |
dc.identifier.scopus | 2-s2.0-84977261333 | |
dc.identifier.wos | 000369515500025 | |
dc.type.version | publishedVersion |