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Evaluation of novel antiproliferative controlled drug delivery system based on poly(2-hydroxypropyl acrylate/itaconic acid) hydrogels and nickel complex with Oxaprozin
A series of dual-sensitive poly(2-hydroxypropyl acrylate/itaconic acid) (P(HPA/IA)) hydrogels were synthesized and evaluated as potential highly effective antiproliferative drug delivery system. Investigated hydrophobic antiproliferative agent, Ni(II) complex with Oxaprozin, was successfully synthesized and efficiently loaded into the'"intelligent" P(HPA/IA) hydrogels. Swelling studies showed that loaded agent did not annul pH- and temperature-sensitivity of the investigated hydrogels. In vitro antiproliferative activity of investigated complex against human cervical (HeLa) and melanoma cancer (FemX) cell lines was tested. The results of in vitro release study at different pH values confirmed synthesized hydrogels loaded with investigated complex as a highly effective pH-triggered drug delivery system for the advanced anticancer therapy as well as for the targeted treatment of intestine/colon cancers.
Keywords:
Hydrogel / Transition metal drug / Controlled drug delivery / Antiproliferative activity
TY - JOUR
AU - Babić, Marija
AU - Božić, Bojan
AU - Božić, Biljana
AU - Filipović, Jovanka
AU - Ušćumlić, Gordana
AU - Tomić, Simonida
PY - 2016
UR - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/3409
AB - A series of dual-sensitive poly(2-hydroxypropyl acrylate/itaconic acid) (P(HPA/IA)) hydrogels were synthesized and evaluated as potential highly effective antiproliferative drug delivery system. Investigated hydrophobic antiproliferative agent, Ni(II) complex with Oxaprozin, was successfully synthesized and efficiently loaded into the'"intelligent" P(HPA/IA) hydrogels. Swelling studies showed that loaded agent did not annul pH- and temperature-sensitivity of the investigated hydrogels. In vitro antiproliferative activity of investigated complex against human cervical (HeLa) and melanoma cancer (FemX) cell lines was tested. The results of in vitro release study at different pH values confirmed synthesized hydrogels loaded with investigated complex as a highly effective pH-triggered drug delivery system for the advanced anticancer therapy as well as for the targeted treatment of intestine/colon cancers.
PB - Elsevier, Amsterdam
T2 - Materials Letters
T1 - Evaluation of novel antiproliferative controlled drug delivery system based on poly(2-hydroxypropyl acrylate/itaconic acid) hydrogels and nickel complex with Oxaprozin
EP - 217
SP - 214
VL - 163
DO - 10.1016/j.matlet.2015.10.078
ER -
@article{
author = "Babić, Marija and Božić, Bojan and Božić, Biljana and Filipović, Jovanka and Ušćumlić, Gordana and Tomić, Simonida",
year = "2016",
abstract = "A series of dual-sensitive poly(2-hydroxypropyl acrylate/itaconic acid) (P(HPA/IA)) hydrogels were synthesized and evaluated as potential highly effective antiproliferative drug delivery system. Investigated hydrophobic antiproliferative agent, Ni(II) complex with Oxaprozin, was successfully synthesized and efficiently loaded into the'"intelligent" P(HPA/IA) hydrogels. Swelling studies showed that loaded agent did not annul pH- and temperature-sensitivity of the investigated hydrogels. In vitro antiproliferative activity of investigated complex against human cervical (HeLa) and melanoma cancer (FemX) cell lines was tested. The results of in vitro release study at different pH values confirmed synthesized hydrogels loaded with investigated complex as a highly effective pH-triggered drug delivery system for the advanced anticancer therapy as well as for the targeted treatment of intestine/colon cancers.",
publisher = "Elsevier, Amsterdam",
journal = "Materials Letters",
title = "Evaluation of novel antiproliferative controlled drug delivery system based on poly(2-hydroxypropyl acrylate/itaconic acid) hydrogels and nickel complex with Oxaprozin",
pages = "217-214",
volume = "163",
doi = "10.1016/j.matlet.2015.10.078"
}
Babić, M., Božić, B., Božić, B., Filipović, J., Ušćumlić, G.,& Tomić, S.. (2016). Evaluation of novel antiproliferative controlled drug delivery system based on poly(2-hydroxypropyl acrylate/itaconic acid) hydrogels and nickel complex with Oxaprozin. in Materials Letters
Elsevier, Amsterdam., 163, 214-217.
https://doi.org/10.1016/j.matlet.2015.10.078
Babić M, Božić B, Božić B, Filipović J, Ušćumlić G, Tomić S. Evaluation of novel antiproliferative controlled drug delivery system based on poly(2-hydroxypropyl acrylate/itaconic acid) hydrogels and nickel complex with Oxaprozin. in Materials Letters. 2016;163:214-217.
doi:10.1016/j.matlet.2015.10.078 .
Babić, Marija, Božić, Bojan, Božić, Biljana, Filipović, Jovanka, Ušćumlić, Gordana, Tomić, Simonida, "Evaluation of novel antiproliferative controlled drug delivery system based on poly(2-hydroxypropyl acrylate/itaconic acid) hydrogels and nickel complex with Oxaprozin" in Materials Letters, 163 (2016):214-217,
https://doi.org/10.1016/j.matlet.2015.10.078 . .
