Evaluation of novel antiproliferative controlled drug delivery system based on poly(2-hydroxypropyl acrylate/itaconic acid) hydrogels and nickel complex with Oxaprozin
Само за регистроване кориснике
2016
Аутори
Babić, MarijaBožić, Bojan
Božić, Biljana
Filipović, Jovanka
Ušćumlić, Gordana
Tomić, Simonida
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
A series of dual-sensitive poly(2-hydroxypropyl acrylate/itaconic acid) (P(HPA/IA)) hydrogels were synthesized and evaluated as potential highly effective antiproliferative drug delivery system. Investigated hydrophobic antiproliferative agent, Ni(II) complex with Oxaprozin, was successfully synthesized and efficiently loaded into the'"intelligent" P(HPA/IA) hydrogels. Swelling studies showed that loaded agent did not annul pH- and temperature-sensitivity of the investigated hydrogels. In vitro antiproliferative activity of investigated complex against human cervical (HeLa) and melanoma cancer (FemX) cell lines was tested. The results of in vitro release study at different pH values confirmed synthesized hydrogels loaded with investigated complex as a highly effective pH-triggered drug delivery system for the advanced anticancer therapy as well as for the targeted treatment of intestine/colon cancers.
Кључне речи:
Hydrogel / Transition metal drug / Controlled drug delivery / Antiproliferative activityИзвор:
Materials Letters, 2016, 163, 214-217Издавач:
- Elsevier, Amsterdam
Финансирање / пројекти:
- Синтеза и карактеризација нових функционалних полимера и полимерних нанокомпозита (RS-172062)
- Проучавање синтезе, структуре и активности органских једињења природног и синтетског порекла (RS-172013)
DOI: 10.1016/j.matlet.2015.10.078
ISSN: 0167-577X
WoS: 000366081400054
Scopus: 2-s2.0-84945379542
Колекције
Институција/група
Tehnološko-metalurški fakultetTY - JOUR AU - Babić, Marija AU - Božić, Bojan AU - Božić, Biljana AU - Filipović, Jovanka AU - Ušćumlić, Gordana AU - Tomić, Simonida PY - 2016 UR - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/3409 AB - A series of dual-sensitive poly(2-hydroxypropyl acrylate/itaconic acid) (P(HPA/IA)) hydrogels were synthesized and evaluated as potential highly effective antiproliferative drug delivery system. Investigated hydrophobic antiproliferative agent, Ni(II) complex with Oxaprozin, was successfully synthesized and efficiently loaded into the'"intelligent" P(HPA/IA) hydrogels. Swelling studies showed that loaded agent did not annul pH- and temperature-sensitivity of the investigated hydrogels. In vitro antiproliferative activity of investigated complex against human cervical (HeLa) and melanoma cancer (FemX) cell lines was tested. The results of in vitro release study at different pH values confirmed synthesized hydrogels loaded with investigated complex as a highly effective pH-triggered drug delivery system for the advanced anticancer therapy as well as for the targeted treatment of intestine/colon cancers. PB - Elsevier, Amsterdam T2 - Materials Letters T1 - Evaluation of novel antiproliferative controlled drug delivery system based on poly(2-hydroxypropyl acrylate/itaconic acid) hydrogels and nickel complex with Oxaprozin EP - 217 SP - 214 VL - 163 DO - 10.1016/j.matlet.2015.10.078 ER -
@article{ author = "Babić, Marija and Božić, Bojan and Božić, Biljana and Filipović, Jovanka and Ušćumlić, Gordana and Tomić, Simonida", year = "2016", abstract = "A series of dual-sensitive poly(2-hydroxypropyl acrylate/itaconic acid) (P(HPA/IA)) hydrogels were synthesized and evaluated as potential highly effective antiproliferative drug delivery system. Investigated hydrophobic antiproliferative agent, Ni(II) complex with Oxaprozin, was successfully synthesized and efficiently loaded into the'"intelligent" P(HPA/IA) hydrogels. Swelling studies showed that loaded agent did not annul pH- and temperature-sensitivity of the investigated hydrogels. In vitro antiproliferative activity of investigated complex against human cervical (HeLa) and melanoma cancer (FemX) cell lines was tested. The results of in vitro release study at different pH values confirmed synthesized hydrogels loaded with investigated complex as a highly effective pH-triggered drug delivery system for the advanced anticancer therapy as well as for the targeted treatment of intestine/colon cancers.", publisher = "Elsevier, Amsterdam", journal = "Materials Letters", title = "Evaluation of novel antiproliferative controlled drug delivery system based on poly(2-hydroxypropyl acrylate/itaconic acid) hydrogels and nickel complex with Oxaprozin", pages = "217-214", volume = "163", doi = "10.1016/j.matlet.2015.10.078" }
Babić, M., Božić, B., Božić, B., Filipović, J., Ušćumlić, G.,& Tomić, S.. (2016). Evaluation of novel antiproliferative controlled drug delivery system based on poly(2-hydroxypropyl acrylate/itaconic acid) hydrogels and nickel complex with Oxaprozin. in Materials Letters Elsevier, Amsterdam., 163, 214-217. https://doi.org/10.1016/j.matlet.2015.10.078
Babić M, Božić B, Božić B, Filipović J, Ušćumlić G, Tomić S. Evaluation of novel antiproliferative controlled drug delivery system based on poly(2-hydroxypropyl acrylate/itaconic acid) hydrogels and nickel complex with Oxaprozin. in Materials Letters. 2016;163:214-217. doi:10.1016/j.matlet.2015.10.078 .
Babić, Marija, Božić, Bojan, Božić, Biljana, Filipović, Jovanka, Ušćumlić, Gordana, Tomić, Simonida, "Evaluation of novel antiproliferative controlled drug delivery system based on poly(2-hydroxypropyl acrylate/itaconic acid) hydrogels and nickel complex with Oxaprozin" in Materials Letters, 163 (2016):214-217, https://doi.org/10.1016/j.matlet.2015.10.078 . .