In this study conditions for green crosslinking with citric acid of chitosan/PEO (polyethylene oxide) nanofibers were evaluated. The thermal in situ crosslinking enabled penetration of crosslinking agent into the matrix providing an improvement of antibacterial activity, thermal stability and mechanical properties of the prepared material. With an increase of temperature above 80 degrees C antibacterial activity against Staphylococcus aureus and Escherichia coil, inversely decreased. Moreover crosslinking provided prolonged controlled drug release with outstanding increase of mechanical properties observed by nanoindentation measurements. Results of the investigation indicated crosslinking as an important parameter for producing material with multifunctional characteristics suitable for drug delivery and tissue engineering.
TY - JOUR
AU - Grković, Mirjana
AU - Stojanović, Dušica
AU - Pavlović, Vladimir B.
AU - Rajilić-Stojanović, Mirjana
AU - Bjelović, Miloš
AU - Uskoković, Petar
PY - 2017
UR - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/3558
AB - In this study conditions for green crosslinking with citric acid of chitosan/PEO (polyethylene oxide) nanofibers were evaluated. The thermal in situ crosslinking enabled penetration of crosslinking agent into the matrix providing an improvement of antibacterial activity, thermal stability and mechanical properties of the prepared material. With an increase of temperature above 80 degrees C antibacterial activity against Staphylococcus aureus and Escherichia coil, inversely decreased. Moreover crosslinking provided prolonged controlled drug release with outstanding increase of mechanical properties observed by nanoindentation measurements. Results of the investigation indicated crosslinking as an important parameter for producing material with multifunctional characteristics suitable for drug delivery and tissue engineering.
PB - Elsevier Sci Ltd, Oxford
T2 - Composites Part B-Engineering
T1 - Improvement of mechanical properties and antibacterial activity of crosslinked electrospun chitosan/poly (ethylene oxide) nanofibers
EP - 67
SP - 58
VL - 121
DO - 10.1016/j.compositesb.2017.03.024
ER -
@article{
author = "Grković, Mirjana and Stojanović, Dušica and Pavlović, Vladimir B. and Rajilić-Stojanović, Mirjana and Bjelović, Miloš and Uskoković, Petar",
year = "2017",
abstract = "In this study conditions for green crosslinking with citric acid of chitosan/PEO (polyethylene oxide) nanofibers were evaluated. The thermal in situ crosslinking enabled penetration of crosslinking agent into the matrix providing an improvement of antibacterial activity, thermal stability and mechanical properties of the prepared material. With an increase of temperature above 80 degrees C antibacterial activity against Staphylococcus aureus and Escherichia coil, inversely decreased. Moreover crosslinking provided prolonged controlled drug release with outstanding increase of mechanical properties observed by nanoindentation measurements. Results of the investigation indicated crosslinking as an important parameter for producing material with multifunctional characteristics suitable for drug delivery and tissue engineering.",
publisher = "Elsevier Sci Ltd, Oxford",
journal = "Composites Part B-Engineering",
title = "Improvement of mechanical properties and antibacterial activity of crosslinked electrospun chitosan/poly (ethylene oxide) nanofibers",
pages = "67-58",
volume = "121",
doi = "10.1016/j.compositesb.2017.03.024"
}
Grković, M., Stojanović, D., Pavlović, V. B., Rajilić-Stojanović, M., Bjelović, M.,& Uskoković, P.. (2017). Improvement of mechanical properties and antibacterial activity of crosslinked electrospun chitosan/poly (ethylene oxide) nanofibers. in Composites Part B-Engineering
Elsevier Sci Ltd, Oxford., 121, 58-67.
https://doi.org/10.1016/j.compositesb.2017.03.024
Grković M, Stojanović D, Pavlović VB, Rajilić-Stojanović M, Bjelović M, Uskoković P. Improvement of mechanical properties and antibacterial activity of crosslinked electrospun chitosan/poly (ethylene oxide) nanofibers. in Composites Part B-Engineering. 2017;121:58-67.
doi:10.1016/j.compositesb.2017.03.024 .
Grković, Mirjana, Stojanović, Dušica, Pavlović, Vladimir B., Rajilić-Stojanović, Mirjana, Bjelović, Miloš, Uskoković, Petar, "Improvement of mechanical properties and antibacterial activity of crosslinked electrospun chitosan/poly (ethylene oxide) nanofibers" in Composites Part B-Engineering, 121 (2017):58-67,
https://doi.org/10.1016/j.compositesb.2017.03.024 . .
