Improvement of mechanical properties and antibacterial activity of crosslinked electrospun chitosan/poly (ethylene oxide) nanofibers
Authorized Users Only
2017
Authors
Grković, MirjanaStojanović, Dušica
Pavlović, Vladimir B.
Rajilić-Stojanović, Mirjana
Bjelović, Miloš
Uskoković, Petar
Article (Published version)
Metadata
Show full item recordAbstract
In this study conditions for green crosslinking with citric acid of chitosan/PEO (polyethylene oxide) nanofibers were evaluated. The thermal in situ crosslinking enabled penetration of crosslinking agent into the matrix providing an improvement of antibacterial activity, thermal stability and mechanical properties of the prepared material. With an increase of temperature above 80 degrees C antibacterial activity against Staphylococcus aureus and Escherichia coil, inversely decreased. Moreover crosslinking provided prolonged controlled drug release with outstanding increase of mechanical properties observed by nanoindentation measurements. Results of the investigation indicated crosslinking as an important parameter for producing material with multifunctional characteristics suitable for drug delivery and tissue engineering.
Keywords:
Polymer-matrix composites (PMCs) / Nano-structures / Mechanical properties / Thermal propertiesSource:
Composites Part B-Engineering, 2017, 121, 58-67Publisher:
- Elsevier Sci Ltd, Oxford
Funding / projects:
- Synthesis, processing and applications of nanostructured multifunctional materials with defined properties (RS-45019)
- Predefined functional properties polymer composite materials processes and equipment development (RS-34011)
DOI: 10.1016/j.compositesb.2017.03.024
ISSN: 1359-8368
WoS: 000407413000005
Scopus: 2-s2.0-85016081941
Institution/Community
Tehnološko-metalurški fakultetTY - JOUR AU - Grković, Mirjana AU - Stojanović, Dušica AU - Pavlović, Vladimir B. AU - Rajilić-Stojanović, Mirjana AU - Bjelović, Miloš AU - Uskoković, Petar PY - 2017 UR - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/3558 AB - In this study conditions for green crosslinking with citric acid of chitosan/PEO (polyethylene oxide) nanofibers were evaluated. The thermal in situ crosslinking enabled penetration of crosslinking agent into the matrix providing an improvement of antibacterial activity, thermal stability and mechanical properties of the prepared material. With an increase of temperature above 80 degrees C antibacterial activity against Staphylococcus aureus and Escherichia coil, inversely decreased. Moreover crosslinking provided prolonged controlled drug release with outstanding increase of mechanical properties observed by nanoindentation measurements. Results of the investigation indicated crosslinking as an important parameter for producing material with multifunctional characteristics suitable for drug delivery and tissue engineering. PB - Elsevier Sci Ltd, Oxford T2 - Composites Part B-Engineering T1 - Improvement of mechanical properties and antibacterial activity of crosslinked electrospun chitosan/poly (ethylene oxide) nanofibers EP - 67 SP - 58 VL - 121 DO - 10.1016/j.compositesb.2017.03.024 ER -
@article{ author = "Grković, Mirjana and Stojanović, Dušica and Pavlović, Vladimir B. and Rajilić-Stojanović, Mirjana and Bjelović, Miloš and Uskoković, Petar", year = "2017", abstract = "In this study conditions for green crosslinking with citric acid of chitosan/PEO (polyethylene oxide) nanofibers were evaluated. The thermal in situ crosslinking enabled penetration of crosslinking agent into the matrix providing an improvement of antibacterial activity, thermal stability and mechanical properties of the prepared material. With an increase of temperature above 80 degrees C antibacterial activity against Staphylococcus aureus and Escherichia coil, inversely decreased. Moreover crosslinking provided prolonged controlled drug release with outstanding increase of mechanical properties observed by nanoindentation measurements. Results of the investigation indicated crosslinking as an important parameter for producing material with multifunctional characteristics suitable for drug delivery and tissue engineering.", publisher = "Elsevier Sci Ltd, Oxford", journal = "Composites Part B-Engineering", title = "Improvement of mechanical properties and antibacterial activity of crosslinked electrospun chitosan/poly (ethylene oxide) nanofibers", pages = "67-58", volume = "121", doi = "10.1016/j.compositesb.2017.03.024" }
Grković, M., Stojanović, D., Pavlović, V. B., Rajilić-Stojanović, M., Bjelović, M.,& Uskoković, P.. (2017). Improvement of mechanical properties and antibacterial activity of crosslinked electrospun chitosan/poly (ethylene oxide) nanofibers. in Composites Part B-Engineering Elsevier Sci Ltd, Oxford., 121, 58-67. https://doi.org/10.1016/j.compositesb.2017.03.024
Grković M, Stojanović D, Pavlović VB, Rajilić-Stojanović M, Bjelović M, Uskoković P. Improvement of mechanical properties and antibacterial activity of crosslinked electrospun chitosan/poly (ethylene oxide) nanofibers. in Composites Part B-Engineering. 2017;121:58-67. doi:10.1016/j.compositesb.2017.03.024 .
Grković, Mirjana, Stojanović, Dušica, Pavlović, Vladimir B., Rajilić-Stojanović, Mirjana, Bjelović, Miloš, Uskoković, Petar, "Improvement of mechanical properties and antibacterial activity of crosslinked electrospun chitosan/poly (ethylene oxide) nanofibers" in Composites Part B-Engineering, 121 (2017):58-67, https://doi.org/10.1016/j.compositesb.2017.03.024 . .