A radial 1D Finite Element for Drug Release from Drug Loaded Nanofibers
Апстракт
The aim of this study was to investigate the release performance of an electrospun composite drug loaded nanofiber mat. Electrospun nanofiber mats are promising as drug carriers which offer site-specific delivery of drugs to a target in the human body and may be used for cancer therapy. The authors have formulated a simple radial 1D finite element, which is used to model diffusion within fibers releasing a drug to the surrounding medium discretized by continuum 3D finite elements. The numerical model includes degradation effects and hydrophobicity at the fibers/surroundings interface. For the purpose of experimental investigation, a poly(D, L-lacticco-glycolic acid) (PLGA) implant has been created at the Faculty of Technology and Metallurgy, University of Belgrade. The radial 1D element provides accurate predictions of the diffusion process and serves as an efficient tool for describing transport inside the polymer fiber and surrounding porous medium; which is illustrated through numer...ical examples.
Кључне речи:
Radial 1D finite element / diffusion / drug transport / emulsion electrospinning / PLGA implantsИзвор:
Journal of the Serbian Society for Computational Mechanics, 2017, 11, 1, 82-93Издавач:
- Univerzitet u Kragujevcu - Fakultet inženjerskih nauka, Kragujevac
Финансирање / пројекти:
- City of Kragujevac, Serbia
- Методе моделирања на више скала са применама у биомедицини (RS-MESTD-Basic Research (BR or ON)-174028)
- Примена биомедицинског инжењеринга у претклиничкој и клиничкој пракси (RS-MESTD-Integrated and Interdisciplinary Research (IIR or III)-41007)
DOI: 10.24874/jsscm.2017.11.01.08
ISSN: 1820-6530
WoS: 000419440000008
Scopus: 2-s2.0-85040786049
Институција/група
Tehnološko-metalurški fakultetTY - JOUR AU - Kojić, M. AU - Milosević, M. AU - Simić, Vladimir AU - Stojanović, Dušica AU - Uskoković, Petar PY - 2017 UR - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/3644 AB - The aim of this study was to investigate the release performance of an electrospun composite drug loaded nanofiber mat. Electrospun nanofiber mats are promising as drug carriers which offer site-specific delivery of drugs to a target in the human body and may be used for cancer therapy. The authors have formulated a simple radial 1D finite element, which is used to model diffusion within fibers releasing a drug to the surrounding medium discretized by continuum 3D finite elements. The numerical model includes degradation effects and hydrophobicity at the fibers/surroundings interface. For the purpose of experimental investigation, a poly(D, L-lacticco-glycolic acid) (PLGA) implant has been created at the Faculty of Technology and Metallurgy, University of Belgrade. The radial 1D element provides accurate predictions of the diffusion process and serves as an efficient tool for describing transport inside the polymer fiber and surrounding porous medium; which is illustrated through numerical examples. PB - Univerzitet u Kragujevcu - Fakultet inženjerskih nauka, Kragujevac T2 - Journal of the Serbian Society for Computational Mechanics T1 - A radial 1D Finite Element for Drug Release from Drug Loaded Nanofibers EP - 93 IS - 1 SP - 82 VL - 11 DO - 10.24874/jsscm.2017.11.01.08 ER -
@article{ author = "Kojić, M. and Milosević, M. and Simić, Vladimir and Stojanović, Dušica and Uskoković, Petar", year = "2017", abstract = "The aim of this study was to investigate the release performance of an electrospun composite drug loaded nanofiber mat. Electrospun nanofiber mats are promising as drug carriers which offer site-specific delivery of drugs to a target in the human body and may be used for cancer therapy. The authors have formulated a simple radial 1D finite element, which is used to model diffusion within fibers releasing a drug to the surrounding medium discretized by continuum 3D finite elements. The numerical model includes degradation effects and hydrophobicity at the fibers/surroundings interface. For the purpose of experimental investigation, a poly(D, L-lacticco-glycolic acid) (PLGA) implant has been created at the Faculty of Technology and Metallurgy, University of Belgrade. The radial 1D element provides accurate predictions of the diffusion process and serves as an efficient tool for describing transport inside the polymer fiber and surrounding porous medium; which is illustrated through numerical examples.", publisher = "Univerzitet u Kragujevcu - Fakultet inženjerskih nauka, Kragujevac", journal = "Journal of the Serbian Society for Computational Mechanics", title = "A radial 1D Finite Element for Drug Release from Drug Loaded Nanofibers", pages = "93-82", number = "1", volume = "11", doi = "10.24874/jsscm.2017.11.01.08" }
Kojić, M., Milosević, M., Simić, V., Stojanović, D.,& Uskoković, P.. (2017). A radial 1D Finite Element for Drug Release from Drug Loaded Nanofibers. in Journal of the Serbian Society for Computational Mechanics Univerzitet u Kragujevcu - Fakultet inženjerskih nauka, Kragujevac., 11(1), 82-93. https://doi.org/10.24874/jsscm.2017.11.01.08
Kojić M, Milosević M, Simić V, Stojanović D, Uskoković P. A radial 1D Finite Element for Drug Release from Drug Loaded Nanofibers. in Journal of the Serbian Society for Computational Mechanics. 2017;11(1):82-93. doi:10.24874/jsscm.2017.11.01.08 .
Kojić, M., Milosević, M., Simić, Vladimir, Stojanović, Dušica, Uskoković, Petar, "A radial 1D Finite Element for Drug Release from Drug Loaded Nanofibers" in Journal of the Serbian Society for Computational Mechanics, 11, no. 1 (2017):82-93, https://doi.org/10.24874/jsscm.2017.11.01.08 . .