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Successive relaxation cycles during long-time cell aggregate rounding after uni-axial compression

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2017
10867_2017_Article_9446.pdf (947.8Kb)
Authors
Pajić-Lijaković, Ivana
Milivojević, Milan
Article (Published version)
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Abstract
The mean features of cell surface rearrangement during cell aggregate rounding after uni-axial compression between parallel plates are considered. This is based on long-time rheological modeling approaches in order to shed further light on collective cell migration. Many aspects of cell migration at the supra-cellular level, such as the coordination between surrounding migrating cell groups that leads to uncorrelated motility, have remained unclear. Aggregate shape changes during rounding are considered depending on the size and homogeneity of 2-D and 3-D cell aggregates. Cell aggregate shape changes that are taking place during successive relaxation cycles have various relaxation rates per cycle. Every relaxation rate is related to the corresponding cell migrating state. If most of the cells migrate per cycle, the relaxation rate is maximal. If most of the cells are in a resting state per cycle, the relaxation rate is nearing zero. If some cell groups migrate while the others, at the ...same time, stay in a resting state, the relaxation rate is lower than that obtained for the migrating cells. The relaxation rates per cycles are not random, but they have a tendency to gather around two or three values indicating an organized cell migrating pattern. Such behavior suggests that uncorrelated motility during collective cell migration in one cycle induces a decrease of the relaxation rate in the next cycle caused by an accumulation of cells in the resting state. However, cells have the ability to overcome these perturbations and re-establish an ordered migrating trend in the next cycle. These perturbations of the cell migrating state are more pronounced for: (1) more mobile cells, (2) a heterogeneous cell population, and (3) a larger cell population under the same experimental conditions.

Keywords:
Cell mobility state / Successive relaxation cycles / Aggregate long-time relaxation / Constitutive model
Source:
Journal of Biological Physics, 2017, 43, 2, 197-209
Publisher:
  • Springer, Dordrecht
Funding / projects:
  • Develooment and utilization of novel and traditional technologies in production of competitive food products with added valued for national and global market - CREATING WEALTH FROM THE WEALTH OF SERBIA (RS-46001)

DOI: 10.1007/s10867-017-9446-7

ISSN: 0092-0606

PubMed: 28337554

WoS: 000403474900003

Scopus: 2-s2.0-85015909208
[ Google Scholar ]
17
10
URI
http://TechnoRep.tmf.bg.ac.rs/handle/123456789/3684
Collections
  • Radovi istraživača / Researchers’ publications (TMF)
Institution/Community
Tehnološko-metalurški fakultet
TY  - JOUR
AU  - Pajić-Lijaković, Ivana
AU  - Milivojević, Milan
PY  - 2017
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/3684
AB  - The mean features of cell surface rearrangement during cell aggregate rounding after uni-axial compression between parallel plates are considered. This is based on long-time rheological modeling approaches in order to shed further light on collective cell migration. Many aspects of cell migration at the supra-cellular level, such as the coordination between surrounding migrating cell groups that leads to uncorrelated motility, have remained unclear. Aggregate shape changes during rounding are considered depending on the size and homogeneity of 2-D and 3-D cell aggregates. Cell aggregate shape changes that are taking place during successive relaxation cycles have various relaxation rates per cycle. Every relaxation rate is related to the corresponding cell migrating state. If most of the cells migrate per cycle, the relaxation rate is maximal. If most of the cells are in a resting state per cycle, the relaxation rate is nearing zero. If some cell groups migrate while the others, at the same time, stay in a resting state, the relaxation rate is lower than that obtained for the migrating cells. The relaxation rates per cycles are not random, but they have a tendency to gather around two or three values indicating an organized cell migrating pattern. Such behavior suggests that uncorrelated motility during collective cell migration in one cycle induces a decrease of the relaxation rate in the next cycle caused by an accumulation of cells in the resting state. However, cells have the ability to overcome these perturbations and re-establish an ordered migrating trend in the next cycle. These perturbations of the cell migrating state are more pronounced for: (1) more mobile cells, (2) a heterogeneous cell population, and (3) a larger cell population under the same experimental conditions.
PB  - Springer, Dordrecht
T2  - Journal of Biological Physics
T1  - Successive relaxation cycles during long-time cell aggregate rounding after uni-axial compression
EP  - 209
IS  - 2
SP  - 197
VL  - 43
DO  - 10.1007/s10867-017-9446-7
ER  - 
@article{
author = "Pajić-Lijaković, Ivana and Milivojević, Milan",
year = "2017",
abstract = "The mean features of cell surface rearrangement during cell aggregate rounding after uni-axial compression between parallel plates are considered. This is based on long-time rheological modeling approaches in order to shed further light on collective cell migration. Many aspects of cell migration at the supra-cellular level, such as the coordination between surrounding migrating cell groups that leads to uncorrelated motility, have remained unclear. Aggregate shape changes during rounding are considered depending on the size and homogeneity of 2-D and 3-D cell aggregates. Cell aggregate shape changes that are taking place during successive relaxation cycles have various relaxation rates per cycle. Every relaxation rate is related to the corresponding cell migrating state. If most of the cells migrate per cycle, the relaxation rate is maximal. If most of the cells are in a resting state per cycle, the relaxation rate is nearing zero. If some cell groups migrate while the others, at the same time, stay in a resting state, the relaxation rate is lower than that obtained for the migrating cells. The relaxation rates per cycles are not random, but they have a tendency to gather around two or three values indicating an organized cell migrating pattern. Such behavior suggests that uncorrelated motility during collective cell migration in one cycle induces a decrease of the relaxation rate in the next cycle caused by an accumulation of cells in the resting state. However, cells have the ability to overcome these perturbations and re-establish an ordered migrating trend in the next cycle. These perturbations of the cell migrating state are more pronounced for: (1) more mobile cells, (2) a heterogeneous cell population, and (3) a larger cell population under the same experimental conditions.",
publisher = "Springer, Dordrecht",
journal = "Journal of Biological Physics",
title = "Successive relaxation cycles during long-time cell aggregate rounding after uni-axial compression",
pages = "209-197",
number = "2",
volume = "43",
doi = "10.1007/s10867-017-9446-7"
}
Pajić-Lijaković, I.,& Milivojević, M.. (2017). Successive relaxation cycles during long-time cell aggregate rounding after uni-axial compression. in Journal of Biological Physics
Springer, Dordrecht., 43(2), 197-209.
https://doi.org/10.1007/s10867-017-9446-7
Pajić-Lijaković I, Milivojević M. Successive relaxation cycles during long-time cell aggregate rounding after uni-axial compression. in Journal of Biological Physics. 2017;43(2):197-209.
doi:10.1007/s10867-017-9446-7 .
Pajić-Lijaković, Ivana, Milivojević, Milan, "Successive relaxation cycles during long-time cell aggregate rounding after uni-axial compression" in Journal of Biological Physics, 43, no. 2 (2017):197-209,
https://doi.org/10.1007/s10867-017-9446-7 . .

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