The preparation and characterization of films and nanofibers with carvedilol as a poorly water-soluble drug in poly (ethylene oxide) (PEO) polymer were investigated. Films are prepared by solution casting method, and nanofibers by electrospinning from a polymer solution. Water and mixture of ethanol and water were used as solvents. FT-IR analysis of the samples showed that there was no interaction between the polymer and the drug substance. DSC analysis revealed that carvedilol was dissolved in the polymer and influenced the degree of crystallinity of PEO. Carvedilol release rate for all of the formulations was increased in comparison with pure carvedilol. Significant differences in the rate of release of carvedilol from the films and nanofibers were observed. Field Emission Scanning Electron Microscope (FESEM) images of the obtained fiber was revealed the dependence of the fiber diameter of formulation and electrospinning process parameters, and consequently influence the amount and d...istribution of carvedilol in the encapsulated fibers.
Keywords:
Nanofibers / Oral films / Dissolution rate / Process parameters / Formulation parameters / Poly (ethylene oxide)
Source:
European Journal of Pharmaceutical Sciences, 2017, 101, 160-166
TY - JOUR
AU - Krstić, Marko
AU - Radojević, Marija
AU - Stojanović, Dušica
AU - Radojević, Vesna
AU - Uskoković, Petar
AU - Ibrić, Svetlana
PY - 2017
UR - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/3749
AB - The preparation and characterization of films and nanofibers with carvedilol as a poorly water-soluble drug in poly (ethylene oxide) (PEO) polymer were investigated. Films are prepared by solution casting method, and nanofibers by electrospinning from a polymer solution. Water and mixture of ethanol and water were used as solvents. FT-IR analysis of the samples showed that there was no interaction between the polymer and the drug substance. DSC analysis revealed that carvedilol was dissolved in the polymer and influenced the degree of crystallinity of PEO. Carvedilol release rate for all of the formulations was increased in comparison with pure carvedilol. Significant differences in the rate of release of carvedilol from the films and nanofibers were observed. Field Emission Scanning Electron Microscope (FESEM) images of the obtained fiber was revealed the dependence of the fiber diameter of formulation and electrospinning process parameters, and consequently influence the amount and distribution of carvedilol in the encapsulated fibers.
PB - Elsevier Science Bv, Amsterdam
T2 - European Journal of Pharmaceutical Sciences
T1 - Formulation and characterization of nanofibers and films with carvedilol prepared by electrospinning and solution casting method
EP - 166
SP - 160
VL - 101
DO - 10.1016/j.ejps.2017.02.006
ER -
@article{
author = "Krstić, Marko and Radojević, Marija and Stojanović, Dušica and Radojević, Vesna and Uskoković, Petar and Ibrić, Svetlana",
year = "2017",
abstract = "The preparation and characterization of films and nanofibers with carvedilol as a poorly water-soluble drug in poly (ethylene oxide) (PEO) polymer were investigated. Films are prepared by solution casting method, and nanofibers by electrospinning from a polymer solution. Water and mixture of ethanol and water were used as solvents. FT-IR analysis of the samples showed that there was no interaction between the polymer and the drug substance. DSC analysis revealed that carvedilol was dissolved in the polymer and influenced the degree of crystallinity of PEO. Carvedilol release rate for all of the formulations was increased in comparison with pure carvedilol. Significant differences in the rate of release of carvedilol from the films and nanofibers were observed. Field Emission Scanning Electron Microscope (FESEM) images of the obtained fiber was revealed the dependence of the fiber diameter of formulation and electrospinning process parameters, and consequently influence the amount and distribution of carvedilol in the encapsulated fibers.",
publisher = "Elsevier Science Bv, Amsterdam",
journal = "European Journal of Pharmaceutical Sciences",
title = "Formulation and characterization of nanofibers and films with carvedilol prepared by electrospinning and solution casting method",
pages = "166-160",
volume = "101",
doi = "10.1016/j.ejps.2017.02.006"
}
Krstić, M., Radojević, M., Stojanović, D., Radojević, V., Uskoković, P.,& Ibrić, S.. (2017). Formulation and characterization of nanofibers and films with carvedilol prepared by electrospinning and solution casting method. in European Journal of Pharmaceutical Sciences
Elsevier Science Bv, Amsterdam., 101, 160-166.
https://doi.org/10.1016/j.ejps.2017.02.006
Krstić M, Radojević M, Stojanović D, Radojević V, Uskoković P, Ibrić S. Formulation and characterization of nanofibers and films with carvedilol prepared by electrospinning and solution casting method. in European Journal of Pharmaceutical Sciences. 2017;101:160-166.
doi:10.1016/j.ejps.2017.02.006 .
Krstić, Marko, Radojević, Marija, Stojanović, Dušica, Radojević, Vesna, Uskoković, Petar, Ibrić, Svetlana, "Formulation and characterization of nanofibers and films with carvedilol prepared by electrospinning and solution casting method" in European Journal of Pharmaceutical Sciences, 101 (2017):160-166,
https://doi.org/10.1016/j.ejps.2017.02.006 . .
