The chromatographic behavior of para substituted anilides of 2,2-dimethylpropanoic, benzoic and alpha -phenyl acetic acid has been studied by reversed-phase high performance liquid chromatography HPLC was performed on a C-18 column with various aqueous methanol mobile phases. The Influence on the retention of anilide type and additional substituents in the molecule is discussed. Several chromatographic hydrophobicity parameters (CHP) have been calculated by linear correlation between log k of the investigated compounds and the concentration of methanol in the mobile phase. The chromatographic hydrophobicity parameters were compared with the log P values calculated by Rekker's fragmental method. The results show moderate correlations of CHIP with log Mus, multiple linear regressions have been applied. It was found that besides log P even the electronic effects of individual polar groups capable of hydrogen bonding proved to be very important in hydrophobic characterization of the molecu...le.
TY - JOUR
AU - Đaković-Sekulić, Tatjana
AU - Petrović, SM
AU - Perišić-Janjić, Nada
AU - Petrović, Slobodan
PY - 2001
UR - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/382
AB - The chromatographic behavior of para substituted anilides of 2,2-dimethylpropanoic, benzoic and alpha -phenyl acetic acid has been studied by reversed-phase high performance liquid chromatography HPLC was performed on a C-18 column with various aqueous methanol mobile phases. The Influence on the retention of anilide type and additional substituents in the molecule is discussed. Several chromatographic hydrophobicity parameters (CHP) have been calculated by linear correlation between log k of the investigated compounds and the concentration of methanol in the mobile phase. The chromatographic hydrophobicity parameters were compared with the log P values calculated by Rekker's fragmental method. The results show moderate correlations of CHIP with log Mus, multiple linear regressions have been applied. It was found that besides log P even the electronic effects of individual polar groups capable of hydrogen bonding proved to be very important in hydrophobic characterization of the molecule.
PB - Springer Heidelberg, Heidelberg
T2 - Chromatographia
T1 - HPLC behavior and hydrophobic parameters of some anilides
EP - 64
IS - 1-2
SP - 60
VL - 54
DO - 10.1007/BF02491834
ER -
@article{
author = "Đaković-Sekulić, Tatjana and Petrović, SM and Perišić-Janjić, Nada and Petrović, Slobodan",
year = "2001",
abstract = "The chromatographic behavior of para substituted anilides of 2,2-dimethylpropanoic, benzoic and alpha -phenyl acetic acid has been studied by reversed-phase high performance liquid chromatography HPLC was performed on a C-18 column with various aqueous methanol mobile phases. The Influence on the retention of anilide type and additional substituents in the molecule is discussed. Several chromatographic hydrophobicity parameters (CHP) have been calculated by linear correlation between log k of the investigated compounds and the concentration of methanol in the mobile phase. The chromatographic hydrophobicity parameters were compared with the log P values calculated by Rekker's fragmental method. The results show moderate correlations of CHIP with log Mus, multiple linear regressions have been applied. It was found that besides log P even the electronic effects of individual polar groups capable of hydrogen bonding proved to be very important in hydrophobic characterization of the molecule.",
publisher = "Springer Heidelberg, Heidelberg",
journal = "Chromatographia",
title = "HPLC behavior and hydrophobic parameters of some anilides",
pages = "64-60",
number = "1-2",
volume = "54",
doi = "10.1007/BF02491834"
}
Đaković-Sekulić, T., Petrović, S., Perišić-Janjić, N.,& Petrović, S.. (2001). HPLC behavior and hydrophobic parameters of some anilides. in Chromatographia
Springer Heidelberg, Heidelberg., 54(1-2), 60-64.
https://doi.org/10.1007/BF02491834
Đaković-Sekulić T, Petrović S, Perišić-Janjić N, Petrović S. HPLC behavior and hydrophobic parameters of some anilides. in Chromatographia. 2001;54(1-2):60-64.
doi:10.1007/BF02491834 .
Đaković-Sekulić, Tatjana, Petrović, SM, Perišić-Janjić, Nada, Petrović, Slobodan, "HPLC behavior and hydrophobic parameters of some anilides" in Chromatographia, 54, no. 1-2 (2001):60-64,
https://doi.org/10.1007/BF02491834 . .
