Приказ основних података о документу

dc.creatorMilosević, Miljan
dc.creatorStojanović, Dušica
dc.creatorSimić, Vladimir
dc.creatorMilicević, Bogdan
dc.creatorRadisavljević, Anđela
dc.creatorUskoković, Petar
dc.creatorKojić, Miloš
dc.date.accessioned2021-03-10T13:45:06Z
dc.date.available2021-03-10T13:45:06Z
dc.date.issued2018
dc.identifier.issn1996-1944
dc.identifier.urihttp://TechnoRep.tmf.bg.ac.rs/handle/123456789/3912
dc.description.abstractDue to the relative ease of producing nanofibers with a core-shell structure, emulsion electrospinning has been investigated intensively in making nanofibrous drug delivery systems for controlled and sustained release. Predictions of drug release rates from the poly (D, L-lactic-co-glycolic acid) (PLGA) produced via emulsion electrospinning can be a very difficult task due to the complexity of the system. A computational finite element methodology was used to calculate the diffusion mass transport of Rhodamine B (fluorescent drug model). Degradation effects and hydrophobicity (partitioning phenomenon) at the fiber/surrounding interface were included in the models. The results are validated by experiments where electrospun PLGA nanofiber mats with different contents were used. A new approach to three-dimensional (3D) modeling of nanofibers is presented in this work. The authors have introduced two original models for diffusive drug release from nanofibers to the 3D surrounding medium discretized by continuum 3D finite elements: (1) A model with simple radial one-dimensional (1D) finite elements, and (2) a model consisting of composite smeared finite elements (CSFEs). Numerical solutions, compared to experiments, demonstrate that both computational models provide accurate predictions of the diffusion process and can therefore serve as efficient tools for describing transport inside a polymer fiber network and drug release to the surrounding porous medium.en
dc.publisherMDPI, Basel
dc.relationinfo:eu-repo/grantAgreement/EC/H2020/777204/EU//
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/174028/RS//
dc.relationinfo:eu-repo/grantAgreement/MESTD/Integrated and Interdisciplinary Research (IIR or III)/41007/RS//
dc.relationinfo:eu-repo/grantAgreement/MESTD/Integrated and Interdisciplinary Research (IIR or III)/45019/RS//
dc.rightsopenAccess
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.sourceMaterials
dc.subjectcomputational modelingen
dc.subjectradial finite elementen
dc.subjectcomposite smeared finite elementen
dc.subjectdiffusionen
dc.subjectemulsion electrospinningen
dc.subjectcontrolled drug releaseen
dc.titleA Computational Model for Drug Release from PLGA Implanten
dc.typearticle
dc.rights.licenseBY
dc.citation.issue12
dc.citation.other11(12): -
dc.citation.rankM22
dc.citation.volume11
dc.identifier.doi10.3390/ma11122416
dc.identifier.fulltexthttp://TechnoRep.tmf.bg.ac.rs/bitstream/id/1679/3909.pdf
dc.identifier.pmid30501079
dc.identifier.scopus2-s2.0-85057570674
dc.identifier.wos000456419200074
dc.type.versionpublishedVersion


Документи

Thumbnail

Овај документ се појављује у следећим колекцијама

Приказ основних података о документу