Cefazolin-loaded polycaprolactone fibers produced via different electrospinning methods: Characterization, drug release and antibacterial effect
Само за регистроване кориснике
2018
Аутори
Radisavljević, AnđelaStojanović, Dušica
Perišić, Srđan
Đokić, Veljko
Radojević, Vesna
Rajilić-Stojanović, Mirjana
Uskoković, Petar
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
Antibiotic containing polycaprolactone (PCL) fibers were produced by using three electrospinning methods: blend, emulsion and co-axial electrospinning (labeled as S1, S2 and S3, respectively). The profiles of drug release from three different systems were studied and antimicrobial properties of produced materials were evaluated. Morphology of the produced fibers was characterized and revealed that cefazolin-loaded PCL fibers had smaller diameter compared to neat PCL fibers, while the chemical interaction between the antibiotic and PCL showed that cefazolin neither had reacted with PCL phase, nor had degraded during the electrospinning process. The crystallinity and thermal characterization of fabricated fibers showed that the addition of cefazolin decreased the crystallinity of PCL. The results of the drug release behavior of the blend and co-axial electrospun fibers was on a higher level (similar to 68% and similar to 43%, respectively) compared to the emulsion electrospun fibers (sim...ilar to 5%), after a period of 30 days. The obtained data had the best fitting with the first order model and the Higuchi model, while the Korsmeyer-Peppas model showed a Pseudo-Fickian diffusion of the drug. Antibacterial evaluations showed that cefazolin-loaded PCL fibers had better effects on Staphylococcus aureus compared to Escherichia coll. during the treatment period and that the effect of the emulsion fibers was notably weaker than the other two studied systems. The aim of the study was to test different systems for control drug release of different dynamics, which will be applied for prevent bacterial accumulation when indwelling urinary catheters, applied for different periods of time.
Кључне речи:
Polycaprolactone / Electrospinning / Cefazolin / Drug release / Drug release kinetics / Antibacterial activityИзвор:
European Journal of Pharmaceutical Sciences, 2018, 124, 26-36Издавач:
- Elsevier, Amsterdam
Финансирање / пројекти:
- Развој опреме и процеса добијања полимерних композитних материјала са унапред дефинисаним функционалним својствима (RS-MESTD-Technological Development (TD or TR)-34011)
- Примена биотехнолошких метода у одрживом искоришћењу нус-производа агроиндустрије (RS-MESTD-Technological Development (TD or TR)-31035)
- Синтеза, развој технологија добијања и примена наноструктурних мултифункционалних материјала дефинисаних својстава (RS-MESTD-Integrated and Interdisciplinary Research (IIR or III)-45019)
DOI: 10.1016/j.ejps.2018.08.023
ISSN: 0928-0987
PubMed: 30130639
WoS: 000447981200004
Scopus: 2-s2.0-85051957041
Колекције
Институција/група
Tehnološko-metalurški fakultetTY - JOUR AU - Radisavljević, Anđela AU - Stojanović, Dušica AU - Perišić, Srđan AU - Đokić, Veljko AU - Radojević, Vesna AU - Rajilić-Stojanović, Mirjana AU - Uskoković, Petar PY - 2018 UR - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/3931 AB - Antibiotic containing polycaprolactone (PCL) fibers were produced by using three electrospinning methods: blend, emulsion and co-axial electrospinning (labeled as S1, S2 and S3, respectively). The profiles of drug release from three different systems were studied and antimicrobial properties of produced materials were evaluated. Morphology of the produced fibers was characterized and revealed that cefazolin-loaded PCL fibers had smaller diameter compared to neat PCL fibers, while the chemical interaction between the antibiotic and PCL showed that cefazolin neither had reacted with PCL phase, nor had degraded during the electrospinning process. The crystallinity and thermal characterization of fabricated fibers showed that the addition of cefazolin decreased the crystallinity of PCL. The results of the drug release behavior of the blend and co-axial electrospun fibers was on a higher level (similar to 68% and similar to 43%, respectively) compared to the emulsion electrospun fibers (similar to 5%), after a period of 30 days. The obtained data had the best fitting with the first order model and the Higuchi model, while the Korsmeyer-Peppas model showed a Pseudo-Fickian diffusion of the drug. Antibacterial evaluations showed that cefazolin-loaded PCL fibers had better effects on Staphylococcus aureus compared to Escherichia coll. during the treatment period and that the effect of the emulsion fibers was notably weaker than the other two studied systems. The aim of the study was to test different systems for control drug release of different dynamics, which will be applied for prevent bacterial accumulation when indwelling urinary catheters, applied for different periods of time. PB - Elsevier, Amsterdam T2 - European Journal of Pharmaceutical Sciences T1 - Cefazolin-loaded polycaprolactone fibers produced via different electrospinning methods: Characterization, drug release and antibacterial effect EP - 36 SP - 26 VL - 124 DO - 10.1016/j.ejps.2018.08.023 ER -
@article{ author = "Radisavljević, Anđela and Stojanović, Dušica and Perišić, Srđan and Đokić, Veljko and Radojević, Vesna and Rajilić-Stojanović, Mirjana and Uskoković, Petar", year = "2018", abstract = "Antibiotic containing polycaprolactone (PCL) fibers were produced by using three electrospinning methods: blend, emulsion and co-axial electrospinning (labeled as S1, S2 and S3, respectively). The profiles of drug release from three different systems were studied and antimicrobial properties of produced materials were evaluated. Morphology of the produced fibers was characterized and revealed that cefazolin-loaded PCL fibers had smaller diameter compared to neat PCL fibers, while the chemical interaction between the antibiotic and PCL showed that cefazolin neither had reacted with PCL phase, nor had degraded during the electrospinning process. The crystallinity and thermal characterization of fabricated fibers showed that the addition of cefazolin decreased the crystallinity of PCL. The results of the drug release behavior of the blend and co-axial electrospun fibers was on a higher level (similar to 68% and similar to 43%, respectively) compared to the emulsion electrospun fibers (similar to 5%), after a period of 30 days. The obtained data had the best fitting with the first order model and the Higuchi model, while the Korsmeyer-Peppas model showed a Pseudo-Fickian diffusion of the drug. Antibacterial evaluations showed that cefazolin-loaded PCL fibers had better effects on Staphylococcus aureus compared to Escherichia coll. during the treatment period and that the effect of the emulsion fibers was notably weaker than the other two studied systems. The aim of the study was to test different systems for control drug release of different dynamics, which will be applied for prevent bacterial accumulation when indwelling urinary catheters, applied for different periods of time.", publisher = "Elsevier, Amsterdam", journal = "European Journal of Pharmaceutical Sciences", title = "Cefazolin-loaded polycaprolactone fibers produced via different electrospinning methods: Characterization, drug release and antibacterial effect", pages = "36-26", volume = "124", doi = "10.1016/j.ejps.2018.08.023" }
Radisavljević, A., Stojanović, D., Perišić, S., Đokić, V., Radojević, V., Rajilić-Stojanović, M.,& Uskoković, P.. (2018). Cefazolin-loaded polycaprolactone fibers produced via different electrospinning methods: Characterization, drug release and antibacterial effect. in European Journal of Pharmaceutical Sciences Elsevier, Amsterdam., 124, 26-36. https://doi.org/10.1016/j.ejps.2018.08.023
Radisavljević A, Stojanović D, Perišić S, Đokić V, Radojević V, Rajilić-Stojanović M, Uskoković P. Cefazolin-loaded polycaprolactone fibers produced via different electrospinning methods: Characterization, drug release and antibacterial effect. in European Journal of Pharmaceutical Sciences. 2018;124:26-36. doi:10.1016/j.ejps.2018.08.023 .
Radisavljević, Anđela, Stojanović, Dušica, Perišić, Srđan, Đokić, Veljko, Radojević, Vesna, Rajilić-Stojanović, Mirjana, Uskoković, Petar, "Cefazolin-loaded polycaprolactone fibers produced via different electrospinning methods: Characterization, drug release and antibacterial effect" in European Journal of Pharmaceutical Sciences, 124 (2018):26-36, https://doi.org/10.1016/j.ejps.2018.08.023 . .