The innovative combined microwave-assisted and photo-polymerization technique for synthesis of the novel degradable hydroxyethyl (meth)acrylate/gelatin based scaffolds
Abstract
The discovery of novel biodegradable biomaterials able to support and control cellular activity as well as development of an enhanced and efficient method for their fabrication, are of paramount importance in the field of tissue engineering. This study highlights the design of novel degradable hydrogels based on gelatin and hydroxyethyl (meth)acrylates using the innovative combined two-step sequential microwave-assisted and UV photo-polymerization technique. Chemical composition, morphology, swelling capacity and degradation rate of the synthesized hydrogels were evaluated by Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), swelling and weight loss measurements. As an initial step for evaluation of performance of the hydrogels in the biological environment, the in vitro biocompatibility of these hydrogels, was evaluated using L929 mouse fibroblasts. Obtained results demonstrated that the hydrogels possess a porous morphology with interconnected pores,... 50% in vitro degradation after 7 months, and satisfied biocompatibility on L929 fibroblast cells. These unique performances of the hydrogels make them promising candidates for in vivo evaluation in clinical studies aiming at tissue regeneration.
Keywords:
Degradable hydrogel / Polymers / Scaffolds / (Meth)acrylate/gelatin based hydrogels / Tissue engineering / BiomaterialsSource:
Materials Letters, 2018, 213, 236-240Publisher:
- Elsevier Science Bv, Amsterdam
Funding / projects:
- Synthesis and characterization of novel functional polymers and polymeric nanocomposites (RS-MESTD-Basic Research (BR or ON)-172062)
- SCOPES (Scientific co-operation between Eastern Europe and Switzerland) project [IZ73Z0_152327]
- Phillip Morris
DOI: 10.1016/j.matlet.2017.11.087
ISSN: 0167-577X
WoS: 000419049300060
Scopus: 2-s2.0-85035362011
Collections
Institution/Community
Tehnološko-metalurški fakultetTY - JOUR AU - Babić, Marija AU - Božić, Bojan AU - Božić, Biljana AU - Ušćumlić, Gordana AU - Tomić, Simonida PY - 2018 UR - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/3979 AB - The discovery of novel biodegradable biomaterials able to support and control cellular activity as well as development of an enhanced and efficient method for their fabrication, are of paramount importance in the field of tissue engineering. This study highlights the design of novel degradable hydrogels based on gelatin and hydroxyethyl (meth)acrylates using the innovative combined two-step sequential microwave-assisted and UV photo-polymerization technique. Chemical composition, morphology, swelling capacity and degradation rate of the synthesized hydrogels were evaluated by Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), swelling and weight loss measurements. As an initial step for evaluation of performance of the hydrogels in the biological environment, the in vitro biocompatibility of these hydrogels, was evaluated using L929 mouse fibroblasts. Obtained results demonstrated that the hydrogels possess a porous morphology with interconnected pores, 50% in vitro degradation after 7 months, and satisfied biocompatibility on L929 fibroblast cells. These unique performances of the hydrogels make them promising candidates for in vivo evaluation in clinical studies aiming at tissue regeneration. PB - Elsevier Science Bv, Amsterdam T2 - Materials Letters T1 - The innovative combined microwave-assisted and photo-polymerization technique for synthesis of the novel degradable hydroxyethyl (meth)acrylate/gelatin based scaffolds EP - 240 SP - 236 VL - 213 DO - 10.1016/j.matlet.2017.11.087 ER -
@article{ author = "Babić, Marija and Božić, Bojan and Božić, Biljana and Ušćumlić, Gordana and Tomić, Simonida", year = "2018", abstract = "The discovery of novel biodegradable biomaterials able to support and control cellular activity as well as development of an enhanced and efficient method for their fabrication, are of paramount importance in the field of tissue engineering. This study highlights the design of novel degradable hydrogels based on gelatin and hydroxyethyl (meth)acrylates using the innovative combined two-step sequential microwave-assisted and UV photo-polymerization technique. Chemical composition, morphology, swelling capacity and degradation rate of the synthesized hydrogels were evaluated by Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), swelling and weight loss measurements. As an initial step for evaluation of performance of the hydrogels in the biological environment, the in vitro biocompatibility of these hydrogels, was evaluated using L929 mouse fibroblasts. Obtained results demonstrated that the hydrogels possess a porous morphology with interconnected pores, 50% in vitro degradation after 7 months, and satisfied biocompatibility on L929 fibroblast cells. These unique performances of the hydrogels make them promising candidates for in vivo evaluation in clinical studies aiming at tissue regeneration.", publisher = "Elsevier Science Bv, Amsterdam", journal = "Materials Letters", title = "The innovative combined microwave-assisted and photo-polymerization technique for synthesis of the novel degradable hydroxyethyl (meth)acrylate/gelatin based scaffolds", pages = "240-236", volume = "213", doi = "10.1016/j.matlet.2017.11.087" }
Babić, M., Božić, B., Božić, B., Ušćumlić, G.,& Tomić, S.. (2018). The innovative combined microwave-assisted and photo-polymerization technique for synthesis of the novel degradable hydroxyethyl (meth)acrylate/gelatin based scaffolds. in Materials Letters Elsevier Science Bv, Amsterdam., 213, 236-240. https://doi.org/10.1016/j.matlet.2017.11.087
Babić M, Božić B, Božić B, Ušćumlić G, Tomić S. The innovative combined microwave-assisted and photo-polymerization technique for synthesis of the novel degradable hydroxyethyl (meth)acrylate/gelatin based scaffolds. in Materials Letters. 2018;213:236-240. doi:10.1016/j.matlet.2017.11.087 .
Babić, Marija, Božić, Bojan, Božić, Biljana, Ušćumlić, Gordana, Tomić, Simonida, "The innovative combined microwave-assisted and photo-polymerization technique for synthesis of the novel degradable hydroxyethyl (meth)acrylate/gelatin based scaffolds" in Materials Letters, 213 (2018):236-240, https://doi.org/10.1016/j.matlet.2017.11.087 . .