Приказ основних података о документу
Novel nano-composite hydrogels with honey effective against multi-resistant clinical strains of Acinetobacter baumannii and Pseudomonas aeruginosa
dc.creator | Stojkovska, Jasmina | |
dc.creator | Petrović, Predrag | |
dc.creator | Jancić, Ivan | |
dc.creator | Milenković, Marina | |
dc.creator | Obradović, Bojana | |
dc.date.accessioned | 2021-03-10T13:53:33Z | |
dc.date.available | 2021-03-10T13:53:33Z | |
dc.date.issued | 2019 | |
dc.identifier.issn | 0175-7598 | |
dc.identifier.uri | http://TechnoRep.tmf.bg.ac.rs/handle/123456789/4043 | |
dc.description.abstract | Novel alginate hydrogels with silver nanoparticles (AgNPs) and honey components were produced with the aim to target multidrug-resistant bacterial strains causing nosocomial wound infections. AgNP synthesis was optimized in highly concentrated honey solutions so that a 5-month stable, colloid solution with 50% of honey and similar to 8 nm AgNPs at neutral pH was obtained. The colloid solution was further used to produce nano-composite Ag/alginate hydrogels in different forms (microbeads, microfibers and discs) that retained all AgNPs and high fractions of honey components (40-60%) as determined by the phenol-sulfuric acid and Folin-Ciocalteu methods. The hydrogels were characterized by UV-Vis spectroscopy and Fourier-transform infrared-attenuated total reflectance spectroscopy while the antibacterial activity was investigated against a broad spectrum of Gram-negative and Gram-positive bacteria, including 13 multi-resistant clinical strains of Acinetobacter baumannii, one clinical strain of Pseudomonas aeruginosa and one clinical strain of Staphylococcus aureus. At the total released silver concentration of similar to 9 mu g/ml, the hydrogels exhibited strong bactericidal activity against standard and most of the investigated multi-resistant hospital strains with the exemption of 3 clinical strains of A. baumannii in which antibacterial effects were absent. These results reveal the need for further in-depth studies of bacterial resistance mechanisms and, in the same time, potentials of the novel Ag/alginate hydrogels with honey components to combat wound infections and enhance healing as non-sticky, antibacterial, and bioactive dressings. | en |
dc.publisher | Springer, New York | |
dc.relation | info:eu-repo/grantAgreement/MESTD/Integrated and Interdisciplinary Research (IIR or III)/45019/RS// | |
dc.rights | restrictedAccess | |
dc.source | Applied Microbiology and Biotechnology | |
dc.subject | Honey | en |
dc.subject | Silver nanoparticles | en |
dc.subject | Nano-composite hydrogels | en |
dc.subject | Multi-resistance | en |
dc.subject | Antibacterial activity | en |
dc.title | Novel nano-composite hydrogels with honey effective against multi-resistant clinical strains of Acinetobacter baumannii and Pseudomonas aeruginosa | en |
dc.type | article | |
dc.rights.license | ARR | |
dc.citation.epage | 8543 | |
dc.citation.issue | 20 | |
dc.citation.other | 103(20): 8529-8543 | |
dc.citation.rank | M21 | |
dc.citation.spage | 8529 | |
dc.citation.volume | 103 | |
dc.identifier.doi | 10.1007/s00253-019-10055-2 | |
dc.identifier.pmid | 31396680 | |
dc.identifier.scopus | 2-s2.0-85070332626 | |
dc.identifier.wos | 000491439700022 | |
dc.type.version | publishedVersion |