Приказ основних података о документу

dc.creatorMilovanović, Stoja
dc.creatorMarković, Darka
dc.creatorIvanović, Jasna
dc.date.accessioned2021-03-10T13:54:43Z
dc.date.available2021-03-10T13:54:43Z
dc.date.issued2019
dc.identifier.issn0262-4893
dc.identifier.urihttp://TechnoRep.tmf.bg.ac.rs/handle/123456789/4061
dc.description.abstractThis study explores utilization of biodegradable and biocompatible polymers for controlled release of natural bioactive substance. For that purpose, poly(epsilon-caprolactone) (PCL) beads, cellulose acetate (CA) film, and poly lactic-co-glycolic acid (PLGA) flakes were impregnated with thymol by employing environmentally friendly process of supercritical carbon dioxide (scCO(2)) impregnation. At selected pressure and temperature, prolongation of operating time increased thymol loading. Pure scCO(2) did not affect CA film with average pore diameter of approximately 3 mu m, while it enabled change of PCL beads and PLGA flakes into foams with average pore diameter approximately 175 mu m and 87 mu m, respectively. Additionally to scCO(2), thymol acted as a plasticizer increasing pore size of polymers up to three times. Kinetic of thymol release from selected samples was tested using phosphate buffer saline at 37 degrees C and successfully described with Korsmeyer-Peppas, zero-order, first-order, and Higuchi models. The suggested method of PCL, CA, and PLGA supercritical impregnation led to development of porous, solvent free, added-value materials that release thymol in a controlled manner from 5 h to several days.en
dc.publisherSage Publications Ltd, London
dc.relationinfo:eu-repo/grantAgreement/MESTD/Integrated and Interdisciplinary Research (IIR or III)/45017/RS//
dc.rightsrestrictedAccess
dc.sourceCellular Polymers
dc.subjectCellulose acetateen
dc.subjectpoly(epsilon-caprolactone)en
dc.subjectpoly lactic-co-glycolic aciden
dc.subjectthymol release kineticen
dc.subjectsuper-critical impregnationen
dc.titleAdded-value porous materials for controlled thymol release obtained by supercritical CO2 impregnation processen
dc.typearticle
dc.rights.licenseARR
dc.citation.epage166
dc.citation.issue5-6
dc.citation.other38(5-6): 153-166
dc.citation.rankM23
dc.citation.spage153
dc.citation.volume38
dc.identifier.doi10.1177/0262489319872329
dc.identifier.scopus2-s2.0-85073007606
dc.identifier.wos000489691200003
dc.type.versionpublishedVersion


Документи

Thumbnail

Овај документ се појављује у следећим колекцијама

Приказ основних података о документу