Soluplus (R), Eudragit (R), HPMC-AS foams and solid dispersions for enhancement of Carvedilol dissolution rate prepared by a supercritical CO2 process
Само за регистроване кориснике
2019
Аутори
Milovanović, Stoja
Đuriš, Jelena

Dapčević, Aleksandra

Medarević, Đorđe

Ibrić, Svetlana

Žižović, Irena

Чланак у часопису (Објављена верзија)

Метаподаци
Приказ свих података о документуАпстракт
The present work is aimed towards designing advanced materials by means of sustainable processes. In that sense, the utilization of supercritical CO2 (scCO(2)) for processing of pharmaceutical polymers (Soluplus (R), Eudragit (R), and hydroxypropyl methylcellulose acetate succinate), alone and with an addition of cardiovascular drug Carvedilol, was explored. Employed single-step static scCO(2) process (pressure of 30 MPa and temperature of 100 degrees C for 2 h) enabled fabrication of solvent-free polymeric foams and Carvedilol solid dispersions with controlled microstructure and average pore diameter of 101-257 pm suitable for application in the pharmaceutical industry. ScCO2 did not remain in the foams after processing or affected the polymer composition, while Carvedilol formed hydrogen bonds with the polymers. Carvedilol was molecularly dispersed in the fabricated solid dispersions and its transition from the crystalline to amorphous form was complete. Korsmeyer-Peppas model was su...ccessfully used for the mathematical description of Carvedilol dissolution from solid dispersions. The dissolution rate of Carvedilol in acidic medium was significantly enhanced by its dispersion in tested polymers using the proposed high-pressure method.
Кључне речи:
Carvedilol / Eudragit (R) / Soluplus (R) / HPMC-AS / Supercritical CO2 / Solid dispersionИзвор:
Polymer Testing, 2019, 76, 54-64Издавач:
- Elsevier Sci Ltd, Oxford
Финансирање / пројекти:
- Функционални физиолошки активни биљни материјали са додатом вредношћу за примену у фармацеутској и прехрамбеној индустрији (RS-45017)
- Развој производа и технологија које обезбеђују жељено ослобађање лековитих супстанци из чврстих фармацеутских облика (RS-34007)
- 0-3D наноструктуре за примену у електроници и обновљивим изворима енергије: синтеза, карактеризација и процесирање (RS-45007)
DOI: 10.1016/j.polymertesting.2019.03.001
ISSN: 0142-9418
WoS: 000479182700006
Scopus: 2-s2.0-85062807468
Институција/група
Tehnološko-metalurški fakultetTY - JOUR AU - Milovanović, Stoja AU - Đuriš, Jelena AU - Dapčević, Aleksandra AU - Medarević, Đorđe AU - Ibrić, Svetlana AU - Žižović, Irena PY - 2019 UR - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/4074 AB - The present work is aimed towards designing advanced materials by means of sustainable processes. In that sense, the utilization of supercritical CO2 (scCO(2)) for processing of pharmaceutical polymers (Soluplus (R), Eudragit (R), and hydroxypropyl methylcellulose acetate succinate), alone and with an addition of cardiovascular drug Carvedilol, was explored. Employed single-step static scCO(2) process (pressure of 30 MPa and temperature of 100 degrees C for 2 h) enabled fabrication of solvent-free polymeric foams and Carvedilol solid dispersions with controlled microstructure and average pore diameter of 101-257 pm suitable for application in the pharmaceutical industry. ScCO2 did not remain in the foams after processing or affected the polymer composition, while Carvedilol formed hydrogen bonds with the polymers. Carvedilol was molecularly dispersed in the fabricated solid dispersions and its transition from the crystalline to amorphous form was complete. Korsmeyer-Peppas model was successfully used for the mathematical description of Carvedilol dissolution from solid dispersions. The dissolution rate of Carvedilol in acidic medium was significantly enhanced by its dispersion in tested polymers using the proposed high-pressure method. PB - Elsevier Sci Ltd, Oxford T2 - Polymer Testing T1 - Soluplus (R), Eudragit (R), HPMC-AS foams and solid dispersions for enhancement of Carvedilol dissolution rate prepared by a supercritical CO2 process EP - 64 SP - 54 VL - 76 DO - 10.1016/j.polymertesting.2019.03.001 ER -
@article{ author = "Milovanović, Stoja and Đuriš, Jelena and Dapčević, Aleksandra and Medarević, Đorđe and Ibrić, Svetlana and Žižović, Irena", year = "2019", abstract = "The present work is aimed towards designing advanced materials by means of sustainable processes. In that sense, the utilization of supercritical CO2 (scCO(2)) for processing of pharmaceutical polymers (Soluplus (R), Eudragit (R), and hydroxypropyl methylcellulose acetate succinate), alone and with an addition of cardiovascular drug Carvedilol, was explored. Employed single-step static scCO(2) process (pressure of 30 MPa and temperature of 100 degrees C for 2 h) enabled fabrication of solvent-free polymeric foams and Carvedilol solid dispersions with controlled microstructure and average pore diameter of 101-257 pm suitable for application in the pharmaceutical industry. ScCO2 did not remain in the foams after processing or affected the polymer composition, while Carvedilol formed hydrogen bonds with the polymers. Carvedilol was molecularly dispersed in the fabricated solid dispersions and its transition from the crystalline to amorphous form was complete. Korsmeyer-Peppas model was successfully used for the mathematical description of Carvedilol dissolution from solid dispersions. The dissolution rate of Carvedilol in acidic medium was significantly enhanced by its dispersion in tested polymers using the proposed high-pressure method.", publisher = "Elsevier Sci Ltd, Oxford", journal = "Polymer Testing", title = "Soluplus (R), Eudragit (R), HPMC-AS foams and solid dispersions for enhancement of Carvedilol dissolution rate prepared by a supercritical CO2 process", pages = "64-54", volume = "76", doi = "10.1016/j.polymertesting.2019.03.001" }
Milovanović, S., Đuriš, J., Dapčević, A., Medarević, Đ., Ibrić, S.,& Žižović, I.. (2019). Soluplus (R), Eudragit (R), HPMC-AS foams and solid dispersions for enhancement of Carvedilol dissolution rate prepared by a supercritical CO2 process. in Polymer Testing Elsevier Sci Ltd, Oxford., 76, 54-64. https://doi.org/10.1016/j.polymertesting.2019.03.001
Milovanović S, Đuriš J, Dapčević A, Medarević Đ, Ibrić S, Žižović I. Soluplus (R), Eudragit (R), HPMC-AS foams and solid dispersions for enhancement of Carvedilol dissolution rate prepared by a supercritical CO2 process. in Polymer Testing. 2019;76:54-64. doi:10.1016/j.polymertesting.2019.03.001 .
Milovanović, Stoja, Đuriš, Jelena, Dapčević, Aleksandra, Medarević, Đorđe, Ibrić, Svetlana, Žižović, Irena, "Soluplus (R), Eudragit (R), HPMC-AS foams and solid dispersions for enhancement of Carvedilol dissolution rate prepared by a supercritical CO2 process" in Polymer Testing, 76 (2019):54-64, https://doi.org/10.1016/j.polymertesting.2019.03.001 . .