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dc.creatorMilovanović, Stoja
dc.creatorĐuriš, Jelena
dc.creatorDapčević, Aleksandra
dc.creatorMedarević, Đorđe
dc.creatorIbrić, Svetlana
dc.creatorŽižović, Irena
dc.date.accessioned2021-03-10T13:55:32Z
dc.date.available2021-03-10T13:55:32Z
dc.date.issued2019
dc.identifier.issn0142-9418
dc.identifier.urihttp://TechnoRep.tmf.bg.ac.rs/handle/123456789/4074
dc.description.abstractThe present work is aimed towards designing advanced materials by means of sustainable processes. In that sense, the utilization of supercritical CO2 (scCO(2)) for processing of pharmaceutical polymers (Soluplus (R), Eudragit (R), and hydroxypropyl methylcellulose acetate succinate), alone and with an addition of cardiovascular drug Carvedilol, was explored. Employed single-step static scCO(2) process (pressure of 30 MPa and temperature of 100 degrees C for 2 h) enabled fabrication of solvent-free polymeric foams and Carvedilol solid dispersions with controlled microstructure and average pore diameter of 101-257 pm suitable for application in the pharmaceutical industry. ScCO2 did not remain in the foams after processing or affected the polymer composition, while Carvedilol formed hydrogen bonds with the polymers. Carvedilol was molecularly dispersed in the fabricated solid dispersions and its transition from the crystalline to amorphous form was complete. Korsmeyer-Peppas model was successfully used for the mathematical description of Carvedilol dissolution from solid dispersions. The dissolution rate of Carvedilol in acidic medium was significantly enhanced by its dispersion in tested polymers using the proposed high-pressure method.en
dc.publisherElsevier Sci Ltd, Oxford
dc.relationinfo:eu-repo/grantAgreement/MESTD/Integrated and Interdisciplinary Research (IIR or III)/45017/RS//
dc.relationinfo:eu-repo/grantAgreement/MESTD/Technological Development (TD or TR)/34007/RS//
dc.relationinfo:eu-repo/grantAgreement/MESTD/Integrated and Interdisciplinary Research (IIR or III)/45007/RS//
dc.rightsrestrictedAccess
dc.sourcePolymer Testing
dc.subjectCarvedilolen
dc.subjectEudragit (R)en
dc.subjectSoluplus (R)en
dc.subjectHPMC-ASen
dc.subjectSupercritical CO2en
dc.subjectSolid dispersionen
dc.titleSoluplus (R), Eudragit (R), HPMC-AS foams and solid dispersions for enhancement of Carvedilol dissolution rate prepared by a supercritical CO2 processen
dc.typearticle
dc.rights.licenseARR
dc.citation.epage64
dc.citation.other76: 54-64
dc.citation.rankM21
dc.citation.spage54
dc.citation.volume76
dc.identifier.doi10.1016/j.polymertesting.2019.03.001
dc.identifier.rcubconv_5908
dc.identifier.scopus2-s2.0-85062807468
dc.identifier.wos000479182700006
dc.type.versionpublishedVersion


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