Приказ основних података о документу
Biomimetic characterization reveals enhancement of hydroxyapatite formation by fluid flow in gellan gum and bioactive glass composite scaffolds
dc.creator | Zvicer, Jovana | |
dc.creator | Medić, Ana | |
dc.creator | Veljović, Đorđe | |
dc.creator | Jevtić, Sanja | |
dc.creator | Novak, Sasa | |
dc.creator | Obradović, Bojana | |
dc.date.accessioned | 2021-03-10T13:56:32Z | |
dc.date.available | 2021-03-10T13:56:32Z | |
dc.date.issued | 2019 | |
dc.identifier.issn | 0142-9418 | |
dc.identifier.uri | http://TechnoRep.tmf.bg.ac.rs/handle/123456789/4090 | |
dc.description.abstract | This study presents production and biomimetic characterization of macroporous composite scaffolds based on gellan gum and nanoparticulate bioactive glass (GG-BAG) under conditions relevant for bone tissue engineering. Formation of hydroxyapatite (HAp) within the scaffolds was investigated in the simulated body fluid (SBF) during 14 days in two biomimetic bioreactors: perfusion bioreactor (1.1 ml/min SBF flowrate) and a bioreactor with coupled dynamic compression and SBF perfusion (5% strain, 0.68 Hz, 1 h on/1 h off, 1.1 ml/min SBF flowrate). HAp formation was evaluated by scanning electron microscopy (FE-SEM), energy dispersive X-ray (EDS) analysis, Fourier transform infrared spectroscopy (FTIR), and X-ray powder diffraction (XRPD). The superficial SBF velocity of 100 mu m/s in perfusion bioreactors induced the formation of abundant cauliflower-like HAp crystals throughout the scaffold interior and flake-like crystals on external surfaces resulting in improved mechanical properties as compared to the initial scaffolds. The obtained results indicate potentials of macro-porous GG-BAG scaffolds in conjunction with perfusion bioreactors for bone tissue engineering demonstrating high bioactivity suited for cultures of osteogenic cells. | en |
dc.publisher | Elsevier Sci Ltd, Oxford | |
dc.relation | info:eu-repo/grantAgreement/MESTD/Integrated and Interdisciplinary Research (IIR or III)/45019/RS// | |
dc.relation | Slovenian Agency for Science (National Program) [P2-0087] | |
dc.rights | restrictedAccess | |
dc.source | Polymer Testing | |
dc.subject | Bone | en |
dc.subject | Tissue engineering | en |
dc.subject | Biomimetic scaffolds | en |
dc.subject | Biomimetic bioreactor | en |
dc.subject | Physiological characterization | en |
dc.title | Biomimetic characterization reveals enhancement of hydroxyapatite formation by fluid flow in gellan gum and bioactive glass composite scaffolds | en |
dc.type | article | |
dc.rights.license | ARR | |
dc.citation.epage | 472 | |
dc.citation.other | 76: 464-472 | |
dc.citation.rank | M21 | |
dc.citation.spage | 464 | |
dc.citation.volume | 76 | |
dc.identifier.doi | 10.1016/j.polymertesting.2019.04.004 | |
dc.identifier.scopus | 2-s2.0-85064158461 | |
dc.identifier.wos | 000479182700050 | |
dc.type.version | publishedVersion |