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dc.creatorMilivojević, Ana
dc.creatorĆorović, Marija
dc.creatorSimović, Milica
dc.creatorBanjanac, Katarina
dc.creatorBlagojević, Stevan N.
dc.creatorPjanović, Rada
dc.creatorBezbradica, Dejan
dc.date.accessioned2021-03-10T14:00:54Z
dc.date.available2021-03-10T14:00:54Z
dc.date.issued2019
dc.identifier.issn0888-5885
dc.identifier.urihttp://TechnoRep.tmf.bg.ac.rs/handle/123456789/4158
dc.description.abstractThe present work describes application of natural triglycerides for lipase-catalyzed esterification of structurally diverse flavonoids-esculin, naringin, and phloridzin. Ester mixtures with laurate, linolenate, or linoleate as prevailing products were obtained in reactions with coconut, linseed, and sunflower oils, respectively. By using response surface methodology, the influences of key experimental factors-reaction time, substrates, and enzyme concentrations-for transesterification of esculin with linseed oil were investigated. High molar conversion (78.5%), product yield (19.13 mg/mL), and specific yield (2.83 mmol/g(enzyme)) were achieved at optimized conditions. Determined optimums were successfully applied in esculin transesterification with other two oils. Furthermore, esculin ester mixtures were incorporated in gel emulsions, and their effect on transepidermal water loss (TEWL) as well as skin sensitivity was examined. Obtained results have shown significant hydration effect and good dermatological compatibility without irritating effects of all examined preparations containing oil-derived esculin esters, making them very prospective for application in skin care products.en
dc.publisherAmer Chemical Soc, Washington
dc.relationSerbian Ministry of Education, Science and Technological Development
dc.relationinfo:eu-repo/grantAgreement/MESTD/Technological Development (TD or TR)/31035/RS//
dc.relationinfo:eu-repo/grantAgreement/MESTD/Integrated and Interdisciplinary Research (IIR or III)/46010/RS//
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172015/RS//
dc.rightsrestrictedAccess
dc.sourceIndustrial & Engineering Chemistry Research
dc.titleNovel Approach for Flavonoid Esters Production: Statistically Optimized Enzymatic Synthesis Using Natural Oils and Application in Cosmeticsen
dc.typearticle
dc.rights.licenseARR
dc.citation.epage3649
dc.citation.issue9
dc.citation.other58(9): 3640-3649
dc.citation.rankM22
dc.citation.spage3640
dc.citation.volume58
dc.identifier.doi10.1021/acs.iecr.8b06113
dc.identifier.rcubconv_5816
dc.identifier.scopus2-s2.0-85062593345
dc.identifier.wos000460996700008
dc.type.versionpublishedVersion


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