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dc.creatorPajić-Lijaković, Ivana
dc.creatorMilivojević, Milan
dc.creatorLević, Steva
dc.creatorTrifković, Kata T.
dc.creatorBalanč, Bojana
dc.creatorNedović, Viktor
dc.creatorStevanović-Dajić, Zora
dc.creatorRadosević, Radenko
dc.creatorBugarski, Branko
dc.date.accessioned2021-03-10T14:01:09Z
dc.date.available2021-03-10T14:01:09Z
dc.date.issued2019
dc.identifier.urihttp://TechnoRep.tmf.bg.ac.rs/handle/123456789/4162
dc.description.abstractSome of the main rheological properties that Ca-alginate hydrogel matrix should satisfy for biomedical and biotechnological applications are the matrix viscoelasticity and the ability of stress relaxation. Although alginate satisfies both of them, experimental data note that cell growth is significantly reduced by microenvironmental effects. Microenvironmental restriction effects are connected to matrix resistance stress accumulation. Matrix stress is generated within the boundary layers around the cell aggregates under compression caused by cell rearrangement and growth. Simultaneously induced relaxation phenomena of both subsystems: (1) immobilized cells and (2) hydrogel matrix occur at three time scales through successive relaxation cycles. Complex dynamics of matrix compression intensifies mechanical and electrostatic cell-matrix interactions. Minimizing of the resistance stress is the strategy for improving the matrix performances. Cell action could be simulated in the experiments without cells during repeated stress relaxation cycles. We consider the physical and chemical modifications of Ca-alginate hydrogel.en
dc.rightsrestrictedAccess
dc.sourceMaterials for Biomedical Engineering: Bioactive Materials, Properties, and Applications
dc.subjectBioprocess optimizationen
dc.subjectHydrogel matrixen
dc.subjectImmobilized cellsen
dc.subjectMathematical modelingen
dc.subjectMatrix resistance stressen
dc.titleMatrix resistance stress reduction-prerequisite for achieving higher concentration of immobilized cellsen
dc.typearticle
dc.rights.licenseARR
dc.citation.epage306
dc.citation.other: 281-306
dc.citation.spage281
dc.identifier.doi10.1016/B978-0-12-818431-8.00009-X
dc.identifier.pmid
dc.identifier.rcubconv_6421
dc.identifier.scopus2-s2.0-85094580424
dc.type.versionpublishedVersion


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