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dc.creatorMilovanović, Stoja
dc.creatorMarković, Darka
dc.creatorMraković, Ana
dc.creatorKuska, Robert
dc.creatorŽižović, Irena
dc.creatorFrerich, Sulamith
dc.creatorIvanović, Jasna
dc.date.accessioned2021-03-10T14:01:53Z
dc.date.available2021-03-10T14:01:53Z
dc.date.issued2019
dc.identifier.issn0928-4931
dc.identifier.urihttp://TechnoRep.tmf.bg.ac.rs/handle/123456789/4173
dc.description.abstractAmorphous, medical grade poly(D,L-lactic acid) (PLA) and poly(D,L-lactic-co-glycolic acid) (PLGA) were used to develop systems for controlled release of a natural bioactive substance - thymol. Supercritical carbon dioxide (scCO(2)) was successfully used both as an impregnation medium for thymol incorporation into the polymer matrix and a foaming agent in a single-step batch process. Impregnation of samples using low to moderate scCO(2) densities (273 kg/m(3) and 630 kg/m(3)) and short processing times (2 h and 4 h) enabled thymol loading of 0.920/0-6.62% and formation of microcellular foams upon system depressurization. Thymol effect on structural and thermal properties on foamed samples was proven by FTIR and DSC. The effect of CO2 under elevated pressure on the neat polymers was analysed by high pressure DSC. Foaming of polymers with lower molecular weight by CO2 of higher density yielded foams with smaller pores. All tested foams released thymol in a controlled manner in phosphate buffered saline (PBS) at 37 degrees C within 3 to 6 weeks. Higher loading and lower cell density favoured thymol release rate, while its concentration in PBS for the tested period depended on foam interaction with the medium. Representative PLGA foam sample with the highest thymol loading (6.62%) showed controlled thymol release within 72 h in mediums having pH values from 1.1 to 7.4.en
dc.publisherElsevier Science Bv, Amsterdam
dc.relationinfo:eu-repo/grantAgreement/MESTD/Integrated and Interdisciplinary Research (IIR or III)/45017/RS//
dc.relationGerman Federal Ministry of Education and Research BMBFFederal Ministry of Education & Research (BMBF) [FKZ 01PL11082B]
dc.relationGerman Academic Exchange Service - DAADDeutscher Akademischer Austausch Dienst (DAAD) [57140416]
dc.rightsrestrictedAccess
dc.sourceMaterials Science & Engineering C-Materials for Biological Applications
dc.subjectFoamingen
dc.subjectImpregnationen
dc.subjectPLAen
dc.subjectPLGAen
dc.subjectSupercritical CO2en
dc.subjectThymolen
dc.titleSupercritical CO2 - assisted production of PLA and PLGA foams for controlled thymol releaseen
dc.typearticle
dc.rights.licenseARR
dc.citation.epage404
dc.citation.other99: 394-404
dc.citation.rankM21
dc.citation.spage394
dc.citation.volume99
dc.identifier.doi10.1016/j.msec.2019.01.106
dc.identifier.pmid30889714
dc.identifier.scopus2-s2.0-85060859267
dc.identifier.wos000463121200041
dc.type.versionpublishedVersion


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Приказ основних података о документу