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Functional Epithelium Remodeling in Response to Applied Stress under In Vitro Conditions

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2019
4892709.pdf (6.056Mb)
Authors
Pajić-Lijaković, Ivana
Milivojević, Milan
Article (Published version)
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Abstract
Mathematical modeling is often used in tissue engineering in order to overcome one of its major challenges: transformation of complex biological and rheological behaviors of cells and tissue in a mathematically predictive and physically manipulative engineering process. The successive accomplishment of this task will greatly help in quantifying and optimizing clinical application of the tissue engineering products. One of the problems emerging in this area is the relation between resting and migrating cell groups, as well as between different configurations of migrating cells and viscoelasticity. A deeper comprehension of the relation between various configurations of migrating cells and viscoelasticity at the supracellular level represents the prerequisite for optimization of the performance of the artificial epithelium. Since resting and migrating cell groups have a considerable difference in stiffness, a change in their mutual volume ratio and distribution may affect the viscoelasti...city of multicellular surfaces. If those cell groups are treated as different phases, then an analogous model may be applied to represent such systems. In this work, a two-step Eyring model is developed in order to demonstrate the main mechanical and biochemical factors that influence configurations of migrating cells. This model could be also used for considering the long-time cell rearrangement under various types of applied stress. The results of this theoretical analysis point out the cause-consequence relationship between the configuration of migrating cells and rheological behavior of multicellular surfaces. Configuration of migrating cells is influenced by mechanical and biochemical perturbations, difficult to measure experimentally, which lead to uncorrelated motility. Uncorrelated motility results in (1) decrease of the volume fraction of migrating cells, (2) change of their configuration, and (3) softening of multicellular surfaces.

Source:
Applied Bionics and Biomechanics, 2019, 2019
Publisher:
  • Hindawi Ltd, London
Funding / projects:
  • Develooment and utilization of novel and traditional technologies in production of competitive food products with added valued for national and global market - CREATING WEALTH FROM THE WEALTH OF SERBIA (RS-46001)

DOI: 10.1155/2019/4892709

ISSN: 1176-2322

PubMed: 31236134

WoS: 000470159700001

Scopus: 2-s2.0-85072026457
[ Google Scholar ]
12
7
URI
http://TechnoRep.tmf.bg.ac.rs/handle/123456789/4210
Collections
  • Radovi istraživača / Researchers’ publications (TMF)
Institution/Community
Tehnološko-metalurški fakultet
TY  - JOUR
AU  - Pajić-Lijaković, Ivana
AU  - Milivojević, Milan
PY  - 2019
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/4210
AB  - Mathematical modeling is often used in tissue engineering in order to overcome one of its major challenges: transformation of complex biological and rheological behaviors of cells and tissue in a mathematically predictive and physically manipulative engineering process. The successive accomplishment of this task will greatly help in quantifying and optimizing clinical application of the tissue engineering products. One of the problems emerging in this area is the relation between resting and migrating cell groups, as well as between different configurations of migrating cells and viscoelasticity. A deeper comprehension of the relation between various configurations of migrating cells and viscoelasticity at the supracellular level represents the prerequisite for optimization of the performance of the artificial epithelium. Since resting and migrating cell groups have a considerable difference in stiffness, a change in their mutual volume ratio and distribution may affect the viscoelasticity of multicellular surfaces. If those cell groups are treated as different phases, then an analogous model may be applied to represent such systems. In this work, a two-step Eyring model is developed in order to demonstrate the main mechanical and biochemical factors that influence configurations of migrating cells. This model could be also used for considering the long-time cell rearrangement under various types of applied stress. The results of this theoretical analysis point out the cause-consequence relationship between the configuration of migrating cells and rheological behavior of multicellular surfaces. Configuration of migrating cells is influenced by mechanical and biochemical perturbations, difficult to measure experimentally, which lead to uncorrelated motility. Uncorrelated motility results in (1) decrease of the volume fraction of migrating cells, (2) change of their configuration, and (3) softening of multicellular surfaces.
PB  - Hindawi Ltd, London
T2  - Applied Bionics and Biomechanics
T1  - Functional Epithelium Remodeling in Response to Applied Stress under In Vitro Conditions
VL  - 2019
DO  - 10.1155/2019/4892709
ER  - 
@article{
author = "Pajić-Lijaković, Ivana and Milivojević, Milan",
year = "2019",
abstract = "Mathematical modeling is often used in tissue engineering in order to overcome one of its major challenges: transformation of complex biological and rheological behaviors of cells and tissue in a mathematically predictive and physically manipulative engineering process. The successive accomplishment of this task will greatly help in quantifying and optimizing clinical application of the tissue engineering products. One of the problems emerging in this area is the relation between resting and migrating cell groups, as well as between different configurations of migrating cells and viscoelasticity. A deeper comprehension of the relation between various configurations of migrating cells and viscoelasticity at the supracellular level represents the prerequisite for optimization of the performance of the artificial epithelium. Since resting and migrating cell groups have a considerable difference in stiffness, a change in their mutual volume ratio and distribution may affect the viscoelasticity of multicellular surfaces. If those cell groups are treated as different phases, then an analogous model may be applied to represent such systems. In this work, a two-step Eyring model is developed in order to demonstrate the main mechanical and biochemical factors that influence configurations of migrating cells. This model could be also used for considering the long-time cell rearrangement under various types of applied stress. The results of this theoretical analysis point out the cause-consequence relationship between the configuration of migrating cells and rheological behavior of multicellular surfaces. Configuration of migrating cells is influenced by mechanical and biochemical perturbations, difficult to measure experimentally, which lead to uncorrelated motility. Uncorrelated motility results in (1) decrease of the volume fraction of migrating cells, (2) change of their configuration, and (3) softening of multicellular surfaces.",
publisher = "Hindawi Ltd, London",
journal = "Applied Bionics and Biomechanics",
title = "Functional Epithelium Remodeling in Response to Applied Stress under In Vitro Conditions",
volume = "2019",
doi = "10.1155/2019/4892709"
}
Pajić-Lijaković, I.,& Milivojević, M.. (2019). Functional Epithelium Remodeling in Response to Applied Stress under In Vitro Conditions. in Applied Bionics and Biomechanics
Hindawi Ltd, London., 2019.
https://doi.org/10.1155/2019/4892709
Pajić-Lijaković I, Milivojević M. Functional Epithelium Remodeling in Response to Applied Stress under In Vitro Conditions. in Applied Bionics and Biomechanics. 2019;2019.
doi:10.1155/2019/4892709 .
Pajić-Lijaković, Ivana, Milivojević, Milan, "Functional Epithelium Remodeling in Response to Applied Stress under In Vitro Conditions" in Applied Bionics and Biomechanics, 2019 (2019),
https://doi.org/10.1155/2019/4892709 . .

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