Приказ основних података о документу

dc.creatorMladenović, Dragana
dc.creatorPejin, Jelena
dc.creatorKocić-Tanackov, Sunčica
dc.creatorĐukić-Vuković, Aleksandra
dc.creatorMojović, Ljiljana
dc.date.accessioned2021-03-10T14:05:11Z
dc.date.available2021-03-10T14:05:11Z
dc.date.issued2019
dc.identifier.issn0273-2289
dc.identifier.urihttp://TechnoRep.tmf.bg.ac.rs/handle/123456789/4224
dc.description.abstractThe aim of this study was to perform the adaptation of Lactobacillus paracasei NRRL B-4564 to substrate through adaptive evolution in order to ensure intensive substrate utilization and enhanced L (+)-lactic acid (LA) production on molasses-enriched potato stillage. To evaluate the strain response to environmental conditions exposed during the adaptation process and to select the best adapted cells, the antioxidant activity and LA-producing capability were assessed in batch fermentation. The most promising adapted strain was further used in a pulsed fed-batch mode. Among three selected adapted strains, L. paracasei A-22 showed considerably improved antioxidant capacity, demonstrating more than onefold higher 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical-scavenging rates compared to parent strain. This strain also exhibited superior LA production in batch fermentation and reached 89.4gL(-1) of LA, with a yield of 0.89gg(-1), a productivity of 1.49gL(-1)h(-1), and an optical purity greater than 99%. Furthermore, in fed-batch mode L. paracasei A-22 resulted in 59% higher LA concentration (169.9gL(-1)) compared to parent strain (107.1gL(-1)). The strain adaptation to molasses environment, performed in this study, is a rather simple and promising method for enhancement of LA production on the complex agro-industrial substrate.en
dc.publisherSpringer, New York
dc.relationinfo:eu-repo/grantAgreement/MESTD/Technological Development (TD or TR)/31017/RS//
dc.rightsrestrictedAccess
dc.sourceApplied Biochemistry and Biotechnology
dc.subjectStrain adaptationen
dc.subjectAntioxidant activityen
dc.subjectLactic aciden
dc.subjectFed-batch fermentationen
dc.subjectSugar beet molassesen
dc.subjectPotato stillageen
dc.titleEnhanced Lactic Acid Production by Adaptive Evolution of Lactobacillus paracasei on Agro-industrial Substrateen
dc.typearticle
dc.rights.licenseARR
dc.citation.epage769
dc.citation.issue3
dc.citation.other187(3): 753-769
dc.citation.rankM22
dc.citation.spage753
dc.citation.volume187
dc.identifier.doi10.1007/s12010-018-2852-x
dc.identifier.pmid30058018
dc.identifier.scopus2-s2.0-85050955692
dc.identifier.wos000463838900007
dc.type.versionpublishedVersion


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Приказ основних података о документу