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dc.creatorTadić, Julijana
dc.creatorMihajlović, Marina
dc.creatorJovanović, Mica
dc.creatorMijin, Dušan
dc.date.accessioned2021-03-10T14:05:50Z
dc.date.available2021-03-10T14:05:50Z
dc.date.issued2019
dc.identifier.issn0352-5139
dc.identifier.urihttp://TechnoRep.tmf.bg.ac.rs/handle/123456789/4234
dc.description.abstractIn this study, six 6- and 1,6-substituted-3-cyano-4-methyl-2-pyridones were synthesized in a continuous flow microreactor system. The syntheses were realized at room temperature and the obtained results were compared to those achieved within classical syntheses. In order to optimize the continuous flow syntheses and increase the yield of the products, the retention time in the microreactor was varied by changing the flow rates of the reactant solutions. Furthermore, the reaction was optimized for 3-cyano-4,6-dimethyl-2-pyridone and 3-cyano-6-hydroxy-4-methyl-2-pyridone, which are comercially important in the pharmaceutical and dye industries. Both 2-pyridones were obtained in satisfactory yield of circa 60 % in less than 10 min. The resulting compounds were characterized by their melting points, FT-IR, H-1-NMR and UV-Vis spectra. The efficiency of the presented method for the synthesis of 2-pyridone-based molecules has promising potential for industrial production.en
dc.publisherSrpsko hemijsko društvo, Beograd
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172013/RS//
dc.relationinfo:eu-repo/grantAgreement/MESTD/Technological Development (TD or TR)/34009/RS//
dc.rightsopenAccess
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/
dc.sourceJournal of the Serbian Chemical Society
dc.subjectmicroreactoren
dc.subject2-pyridoneen
dc.subjectbatchen
dc.subjectflow synthesisen
dc.subjectprocess intensificationen
dc.titleContinuous flow synthesis of some 6-and 1,6-substituted 3-cyano-4-methyl-2-pyridonesen
dc.typearticle
dc.rights.licenseBY-NC-ND
dc.citation.epage538
dc.citation.issue6
dc.citation.other84(6): 531-538
dc.citation.rankM23
dc.citation.spage531
dc.citation.volume84
dc.identifier.doi10.2298/JSC180703092T
dc.identifier.fulltexthttp://TechnoRep.tmf.bg.ac.rs/bitstream/id/10014/0352-51391800092T.pdf
dc.identifier.rcubconv_5886
dc.identifier.scopus2-s2.0-85071225030
dc.identifier.wos000474347000001
dc.type.versionpublishedVersion


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