Приказ основних података о документу

dc.creatorVastag, Gyongyi
dc.creatorApostolov, Suzana
dc.creatorMijin, Dušan
dc.creatorGrbović, Ljubica
dc.creatorKaurinović, Biljana
dc.date.accessioned2021-03-10T14:11:15Z
dc.date.available2021-03-10T14:11:15Z
dc.date.issued2019
dc.identifier.issn0886-9383
dc.identifier.urihttp://TechnoRep.tmf.bg.ac.rs/handle/123456789/4318
dc.description.abstractSelected chemometric methods were used to form models that define the qualitative and quantitative dependence between the chemical structure and the parameters of potential biological activity (lipophilicity, retention, pharmacokinetic, and toxic properties) of the selected diphenylacetamide derivatives. The chromatographic retention parameters of the selected diphenylacetamides were determined by applying reversed-phase thin-layer chromatography (RPTLC) on C18 and cyano modified carriers in mixtures of water-methanol and water-acetone. It was found that the polarity of the substituent R has dominant influence and its electronic effects to a lesser extent, on the studied parameters of the biological activity of diphenylacetamides. Also, results suggest a better similarity of the retention constants, R-M(0), with parameters of lipophilicity and pharmacokinetic predictors. Contrary to that, chromatographic parameter, m, exhibits a greater resemblance with toxicity parameters.en
dc.publisherWiley, Hoboken
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172013/RS//
dc.rightsrestrictedAccess
dc.sourceJournal of Chemometrics
dc.subjectbioactivity parametersen
dc.subjectchemometricsen
dc.subjectdiphenylacetamidesen
dc.titleChemometric study of chromatographic and computational bioactivity parameters of diphenylacetamidesen
dc.typearticle
dc.rights.licenseARR
dc.citation.issue2
dc.citation.other33(2): -
dc.citation.rankM22
dc.citation.volume33
dc.identifier.doi10.1002/cem.3091
dc.identifier.scopus2-s2.0-85055717498
dc.identifier.wos000457749700003
dc.type.versionpublishedVersion


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Приказ основних података о документу