Since the management of infections becomes prior global healthcare issue, the "post antibiotic era" requires innovative and interdisciplinary approach. As an alternative to widespread and, nowdays mostly uneffective, antibiotic treatment of infections, the series of hydrogels were developed and further investigated as novel antibacterial biomaterials. The hydrogels based on 2-hydroxyethyl acrylate and itaconic acid were synthesized and used for silver(I) ions incorporation. The structural, thermal and swelling characteristics were examined by Fourier transform infrared spectroscopy, differential scanning calorimetry, and swelling study conducted in wide range of pHs at 37 degrees C. Results confirmed the expected structure, while the glass transition temperatures (T-g) of the hydrogels were detected in range of 10-37 degrees C. The in vitro release study revealed suitability of these pH sensitive hydrogels as the systems for topical delivery of silver(I) ions. Performed MTT test and Co...met assay proved biocompatibility of the hydrogels, as well as the absence of acute genotoxic effect on human fibroblast cells (MRC-5). The hydrogels exhibited satisfying antibacterial activity against methicillin sensitive Staphylococcus aureus (MSSA) and methicillin resistant Staphylococcus aureus (MRSA), indicating the capacity to treat the life-threatening infections.
TY - JOUR
AU - Vuković, Jovana
AU - Perić-Grujić, Aleksandra
AU - Mitić-Culafić, Dragana S.
AU - Božić-Nedeljković, Biljana
AU - Tomić, Simonida
PY - 2020
UR - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/4345
AB - Since the management of infections becomes prior global healthcare issue, the "post antibiotic era" requires innovative and interdisciplinary approach. As an alternative to widespread and, nowdays mostly uneffective, antibiotic treatment of infections, the series of hydrogels were developed and further investigated as novel antibacterial biomaterials. The hydrogels based on 2-hydroxyethyl acrylate and itaconic acid were synthesized and used for silver(I) ions incorporation. The structural, thermal and swelling characteristics were examined by Fourier transform infrared spectroscopy, differential scanning calorimetry, and swelling study conducted in wide range of pHs at 37 degrees C. Results confirmed the expected structure, while the glass transition temperatures (T-g) of the hydrogels were detected in range of 10-37 degrees C. The in vitro release study revealed suitability of these pH sensitive hydrogels as the systems for topical delivery of silver(I) ions. Performed MTT test and Comet assay proved biocompatibility of the hydrogels, as well as the absence of acute genotoxic effect on human fibroblast cells (MRC-5). The hydrogels exhibited satisfying antibacterial activity against methicillin sensitive Staphylococcus aureus (MSSA) and methicillin resistant Staphylococcus aureus (MRSA), indicating the capacity to treat the life-threatening infections.
PB - Polymer Soc Korea, Seoul
T2 - Macromolecular Research
T1 - Antibacterial Activity of pH-Sensitive Silver(I)/Poly(2-hydroxyethyl acrylate/itaconic acid) Hydrogels
EP - 389
IS - 4
SP - 382
VL - 28
DO - 10.1007/s13233-020-8050-z
ER -
@article{
author = "Vuković, Jovana and Perić-Grujić, Aleksandra and Mitić-Culafić, Dragana S. and Božić-Nedeljković, Biljana and Tomić, Simonida",
year = "2020",
abstract = "Since the management of infections becomes prior global healthcare issue, the "post antibiotic era" requires innovative and interdisciplinary approach. As an alternative to widespread and, nowdays mostly uneffective, antibiotic treatment of infections, the series of hydrogels were developed and further investigated as novel antibacterial biomaterials. The hydrogels based on 2-hydroxyethyl acrylate and itaconic acid were synthesized and used for silver(I) ions incorporation. The structural, thermal and swelling characteristics were examined by Fourier transform infrared spectroscopy, differential scanning calorimetry, and swelling study conducted in wide range of pHs at 37 degrees C. Results confirmed the expected structure, while the glass transition temperatures (T-g) of the hydrogels were detected in range of 10-37 degrees C. The in vitro release study revealed suitability of these pH sensitive hydrogels as the systems for topical delivery of silver(I) ions. Performed MTT test and Comet assay proved biocompatibility of the hydrogels, as well as the absence of acute genotoxic effect on human fibroblast cells (MRC-5). The hydrogels exhibited satisfying antibacterial activity against methicillin sensitive Staphylococcus aureus (MSSA) and methicillin resistant Staphylococcus aureus (MRSA), indicating the capacity to treat the life-threatening infections.",
publisher = "Polymer Soc Korea, Seoul",
journal = "Macromolecular Research",
title = "Antibacterial Activity of pH-Sensitive Silver(I)/Poly(2-hydroxyethyl acrylate/itaconic acid) Hydrogels",
pages = "389-382",
number = "4",
volume = "28",
doi = "10.1007/s13233-020-8050-z"
}
Vuković, J., Perić-Grujić, A., Mitić-Culafić, D. S., Božić-Nedeljković, B.,& Tomić, S.. (2020). Antibacterial Activity of pH-Sensitive Silver(I)/Poly(2-hydroxyethyl acrylate/itaconic acid) Hydrogels. in Macromolecular Research
Polymer Soc Korea, Seoul., 28(4), 382-389.
https://doi.org/10.1007/s13233-020-8050-z
Vuković J, Perić-Grujić A, Mitić-Culafić DS, Božić-Nedeljković B, Tomić S. Antibacterial Activity of pH-Sensitive Silver(I)/Poly(2-hydroxyethyl acrylate/itaconic acid) Hydrogels. in Macromolecular Research. 2020;28(4):382-389.
doi:10.1007/s13233-020-8050-z .
