Thermo-responsive hydrogels based on poly(N-isopropyl- acrylamide) and hyaluronic acid cross-linked with nanoclays
Autori
Mirković, IlinkaNikolić, Marija
Ostojić, Sanja
Maletaškić, Jelena
Petrović, Zoran
Đonlagić, Jasna
Članak u časopisu (Objavljena verzija)
Metapodaci
Prikaz svih podataka o dokumentuApstrakt
Semi-interpenetrating polymer networks (SIPN) based on thermo-responsive poly(N-isopropylacrylamide) (PNIPA) and water-soluble sodium salts of linear hyaluronic acid (Na-HA) were physically cross-linked with synthetic nanoclay (laponite XLG). PNIPA hydrogels with different cross-linking densities and Na-HA concentrations were synthesized by in situ free-radical redox polymerization. The structure and heterogeneity of the semi-IPN hydrogels were examined by SEM and XRD. The content of clay incorporated in the gel was determined by TGA. DSC measurements showed that volume phase transition temperature and its enthalpy varied with the clay and hyaluronic acid content. SIPN hydrogels containing negatively charged polyelectrolyte, Na-HA, exhibited higher Q(e) and faster deswelling rates than the corresponding PNIPA NC hydrogels. The presence of the anionic Na-HA polymer reduced the storage modulus, indicating a weakening of the hydrogel network structure, especially at lower clay contents. T...he nanocomposite hydrogels exhibited high tan delta values, which increased with increasing Na-HA content.
Ključne reči:
thermo-responsive hydrogels / semi-IPN hydrogels / nanoclay / hyaluronic acid / swelling/deswelling kineticsIzvor:
Journal of the Serbian Chemical Society, 2020, 85, 9, 1197-1221Izdavač:
- Srpsko hemijsko društvo, Beograd
Finansiranje / projekti:
DOI: 10.2298/JSC200109023M
ISSN: 0352-5139
WoS: 000573967900008
Scopus: 2-s2.0-85094926034
Institucija/grupa
Tehnološko-metalurški fakultetTY - JOUR AU - Mirković, Ilinka AU - Nikolić, Marija AU - Ostojić, Sanja AU - Maletaškić, Jelena AU - Petrović, Zoran AU - Đonlagić, Jasna PY - 2020 UR - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/4365 AB - Semi-interpenetrating polymer networks (SIPN) based on thermo-responsive poly(N-isopropylacrylamide) (PNIPA) and water-soluble sodium salts of linear hyaluronic acid (Na-HA) were physically cross-linked with synthetic nanoclay (laponite XLG). PNIPA hydrogels with different cross-linking densities and Na-HA concentrations were synthesized by in situ free-radical redox polymerization. The structure and heterogeneity of the semi-IPN hydrogels were examined by SEM and XRD. The content of clay incorporated in the gel was determined by TGA. DSC measurements showed that volume phase transition temperature and its enthalpy varied with the clay and hyaluronic acid content. SIPN hydrogels containing negatively charged polyelectrolyte, Na-HA, exhibited higher Q(e) and faster deswelling rates than the corresponding PNIPA NC hydrogels. The presence of the anionic Na-HA polymer reduced the storage modulus, indicating a weakening of the hydrogel network structure, especially at lower clay contents. The nanocomposite hydrogels exhibited high tan delta values, which increased with increasing Na-HA content. PB - Srpsko hemijsko društvo, Beograd T2 - Journal of the Serbian Chemical Society T1 - Thermo-responsive hydrogels based on poly(N-isopropyl- acrylamide) and hyaluronic acid cross-linked with nanoclays EP - 1221 IS - 9 SP - 1197 VL - 85 DO - 10.2298/JSC200109023M ER -
@article{ author = "Mirković, Ilinka and Nikolić, Marija and Ostojić, Sanja and Maletaškić, Jelena and Petrović, Zoran and Đonlagić, Jasna", year = "2020", abstract = "Semi-interpenetrating polymer networks (SIPN) based on thermo-responsive poly(N-isopropylacrylamide) (PNIPA) and water-soluble sodium salts of linear hyaluronic acid (Na-HA) were physically cross-linked with synthetic nanoclay (laponite XLG). PNIPA hydrogels with different cross-linking densities and Na-HA concentrations were synthesized by in situ free-radical redox polymerization. The structure and heterogeneity of the semi-IPN hydrogels were examined by SEM and XRD. The content of clay incorporated in the gel was determined by TGA. DSC measurements showed that volume phase transition temperature and its enthalpy varied with the clay and hyaluronic acid content. SIPN hydrogels containing negatively charged polyelectrolyte, Na-HA, exhibited higher Q(e) and faster deswelling rates than the corresponding PNIPA NC hydrogels. The presence of the anionic Na-HA polymer reduced the storage modulus, indicating a weakening of the hydrogel network structure, especially at lower clay contents. The nanocomposite hydrogels exhibited high tan delta values, which increased with increasing Na-HA content.", publisher = "Srpsko hemijsko društvo, Beograd", journal = "Journal of the Serbian Chemical Society", title = "Thermo-responsive hydrogels based on poly(N-isopropyl- acrylamide) and hyaluronic acid cross-linked with nanoclays", pages = "1221-1197", number = "9", volume = "85", doi = "10.2298/JSC200109023M" }
Mirković, I., Nikolić, M., Ostojić, S., Maletaškić, J., Petrović, Z.,& Đonlagić, J.. (2020). Thermo-responsive hydrogels based on poly(N-isopropyl- acrylamide) and hyaluronic acid cross-linked with nanoclays. in Journal of the Serbian Chemical Society Srpsko hemijsko društvo, Beograd., 85(9), 1197-1221. https://doi.org/10.2298/JSC200109023M
Mirković I, Nikolić M, Ostojić S, Maletaškić J, Petrović Z, Đonlagić J. Thermo-responsive hydrogels based on poly(N-isopropyl- acrylamide) and hyaluronic acid cross-linked with nanoclays. in Journal of the Serbian Chemical Society. 2020;85(9):1197-1221. doi:10.2298/JSC200109023M .
Mirković, Ilinka, Nikolić, Marija, Ostojić, Sanja, Maletaškić, Jelena, Petrović, Zoran, Đonlagić, Jasna, "Thermo-responsive hydrogels based on poly(N-isopropyl- acrylamide) and hyaluronic acid cross-linked with nanoclays" in Journal of the Serbian Chemical Society, 85, no. 9 (2020):1197-1221, https://doi.org/10.2298/JSC200109023M . .