Use of carbon paste electrode and modified by gold nanoparticles for selected macrolide antibiotics determination as standard and in pharmaceutical preparations
Samo za registrovane korisnike
2020
Autori
Vajdle, OlgaŠekuljica, Sanja
Guzsvány, Valéria
Nagy, László
Kónya, Zoltán
Avramov-Ivić, Milka
Mijin, Dušan
Petrović, Slobodan
Anojčić, Jasmina
Članak u časopisu (Objavljena verzija)
Metapodaci
Prikaz svih podataka o dokumentuApstrakt
In this work, carbon paste electrode (CPE) and carbon paste electrode modified with gold nanoparticics (AuNPs/CPE) were employed with rapid direct anodic square wave voltammetry (SWV) for macrolide antibiotics erythromycin cthylsuccinate (EIS), azithromycin (A7.1), clarithromycin (OA) and roxithromycin (ROX) determination. The surface of working electrodes was morphologically characterized by scanning electron microscopic (SEM) measurements whereby the presence of randomly distributed AuNPs of 10 nm diameter size on CPE surface was confirmed by energy dispersive spectrometer (EDS). SWV determination of four macrolide antibiotics using CPE was performed in aqueous Britton-Robinson buffer solutions (pH 2.0 to 11.98) showing that oxidation signals strongly depend upon pH (at pH gt = 6) and exhibited the most favorable characteristics at pH 8.0 in the case of EES and pH 11.98 in the case of AZI, CIA and ROX. Under optimized conditions, the SWV method using CPE enables determination of all... investigated macrolide antibiotics in low mu g mL(-1) concentration ranges with relative standard deviations (RSDs) lower than 6% and achieved detection limits (1.0Ds) as 0.18, 0.045, 1.43 and 0.30 mu g mL(-1) for EES, AZI, CLA and ROX, respectively. In the case of AZ1 and ROX, it was demonstrated that the use of AuNPs/CPE as working electrode could additionally improve the results obtained with the SWV method concerning exhibited sensitivity, reproducibility and linear concentration range, due to the electrocatalytic properties of synthesized AuNPs. The optimized experimental parameters with the use of SWV method and CPF. or AuNPs/CPE were successfully applied for determination of ROX and AZI in their pharmaceutical preparations Runac (R) and Ilemomycine, respectively. The reliability of the elaborated procedures and thus the accuracy of the obtained results were validated by comparing them with those obtained by means of H PLC-DAD measurements.
Ključne reči:
Macrolide antibiotics / Square wave voltammetry / Carbon paste electrode / Gold nanoparticles / Pharmaceutical preparationsIzvor:
Journal of Electroanalytical Chemistry, 2020, 873, 114324-Izdavač:
- Elsevier B.V.
Finansiranje / projekti:
- Ministarstvo nauke, tehnološkog razvoja i inovacija Republike Srbije, institucionalno finansiranje - 200125 (Univerzitet u Novom Sadu, Prirodno-matematički fakultet) (RS-MESTD-inst-2020-200125)
- CEEPUSIII network [CZ-0212-131920]
Napomena:
- Peer-reviewed manuscript: http://technorep.tmf.bg.ac.rs/handle/123456789/4726
Povezane informacije:
- Verzija dokumenta
http://technorep.tmf.bg.ac.rs/handle/123456789/4726
DOI: 10.1016/j.jelechem.2020.114324
ISSN: 1572-6657
WoS: 000572073600001
Scopus: 2-s2.0-85086820704
Institucija/grupa
Tehnološko-metalurški fakultetTY - JOUR AU - Vajdle, Olga AU - Šekuljica, Sanja AU - Guzsvány, Valéria AU - Nagy, László AU - Kónya, Zoltán AU - Avramov-Ivić, Milka AU - Mijin, Dušan AU - Petrović, Slobodan AU - Anojčić, Jasmina PY - 2020 UR - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/4392 AB - In this work, carbon paste electrode (CPE) and carbon paste electrode modified with gold nanoparticics (AuNPs/CPE) were employed with rapid direct anodic square wave voltammetry (SWV) for macrolide antibiotics erythromycin cthylsuccinate (EIS), azithromycin (A7.1), clarithromycin (OA) and roxithromycin (ROX) determination. The surface of working electrodes was morphologically characterized by scanning electron microscopic (SEM) measurements whereby the presence of randomly distributed AuNPs of 10 nm diameter size on CPE surface was confirmed by energy dispersive spectrometer (EDS). SWV determination of four macrolide antibiotics using CPE was performed in aqueous Britton-Robinson buffer solutions (pH 2.0 to 11.98) showing that oxidation signals strongly depend upon pH (at pH gt = 6) and exhibited the most favorable characteristics at pH 8.0 in the case of EES and pH 11.98 in the case of AZI, CIA and ROX. Under optimized conditions, the SWV method using CPE enables determination of all investigated macrolide antibiotics in low mu g mL(-1) concentration ranges with relative standard deviations (RSDs) lower than 6% and achieved detection limits (1.0Ds) as 0.18, 0.045, 1.43 and 0.30 mu g mL(-1) for EES, AZI, CLA and ROX, respectively. In the case of AZ1 and ROX, it was demonstrated that the use of AuNPs/CPE as working electrode could additionally improve the results obtained with the SWV method concerning exhibited sensitivity, reproducibility and linear concentration range, due to the electrocatalytic properties of synthesized AuNPs. The optimized experimental parameters with the use of SWV method and CPF. or AuNPs/CPE were successfully applied for determination of ROX and AZI in their pharmaceutical preparations Runac (R) and Ilemomycine, respectively. The reliability of the elaborated procedures and thus the accuracy of the obtained results were validated by comparing them with those obtained by means of H PLC-DAD measurements. PB - Elsevier B.V. T2 - Journal of Electroanalytical Chemistry T1 - Use of carbon paste electrode and modified by gold nanoparticles for selected macrolide antibiotics determination as standard and in pharmaceutical preparations SP - 114324 VL - 873 DO - 10.1016/j.jelechem.2020.114324 ER -
@article{ author = "Vajdle, Olga and Šekuljica, Sanja and Guzsvány, Valéria and Nagy, László and Kónya, Zoltán and Avramov-Ivić, Milka and Mijin, Dušan and Petrović, Slobodan and Anojčić, Jasmina", year = "2020", abstract = "In this work, carbon paste electrode (CPE) and carbon paste electrode modified with gold nanoparticics (AuNPs/CPE) were employed with rapid direct anodic square wave voltammetry (SWV) for macrolide antibiotics erythromycin cthylsuccinate (EIS), azithromycin (A7.1), clarithromycin (OA) and roxithromycin (ROX) determination. The surface of working electrodes was morphologically characterized by scanning electron microscopic (SEM) measurements whereby the presence of randomly distributed AuNPs of 10 nm diameter size on CPE surface was confirmed by energy dispersive spectrometer (EDS). SWV determination of four macrolide antibiotics using CPE was performed in aqueous Britton-Robinson buffer solutions (pH 2.0 to 11.98) showing that oxidation signals strongly depend upon pH (at pH gt = 6) and exhibited the most favorable characteristics at pH 8.0 in the case of EES and pH 11.98 in the case of AZI, CIA and ROX. Under optimized conditions, the SWV method using CPE enables determination of all investigated macrolide antibiotics in low mu g mL(-1) concentration ranges with relative standard deviations (RSDs) lower than 6% and achieved detection limits (1.0Ds) as 0.18, 0.045, 1.43 and 0.30 mu g mL(-1) for EES, AZI, CLA and ROX, respectively. In the case of AZ1 and ROX, it was demonstrated that the use of AuNPs/CPE as working electrode could additionally improve the results obtained with the SWV method concerning exhibited sensitivity, reproducibility and linear concentration range, due to the electrocatalytic properties of synthesized AuNPs. The optimized experimental parameters with the use of SWV method and CPF. or AuNPs/CPE were successfully applied for determination of ROX and AZI in their pharmaceutical preparations Runac (R) and Ilemomycine, respectively. The reliability of the elaborated procedures and thus the accuracy of the obtained results were validated by comparing them with those obtained by means of H PLC-DAD measurements.", publisher = "Elsevier B.V.", journal = "Journal of Electroanalytical Chemistry", title = "Use of carbon paste electrode and modified by gold nanoparticles for selected macrolide antibiotics determination as standard and in pharmaceutical preparations", pages = "114324", volume = "873", doi = "10.1016/j.jelechem.2020.114324" }
Vajdle, O., Šekuljica, S., Guzsvány, V., Nagy, L., Kónya, Z., Avramov-Ivić, M., Mijin, D., Petrović, S.,& Anojčić, J.. (2020). Use of carbon paste electrode and modified by gold nanoparticles for selected macrolide antibiotics determination as standard and in pharmaceutical preparations. in Journal of Electroanalytical Chemistry Elsevier B.V.., 873, 114324. https://doi.org/10.1016/j.jelechem.2020.114324
Vajdle O, Šekuljica S, Guzsvány V, Nagy L, Kónya Z, Avramov-Ivić M, Mijin D, Petrović S, Anojčić J. Use of carbon paste electrode and modified by gold nanoparticles for selected macrolide antibiotics determination as standard and in pharmaceutical preparations. in Journal of Electroanalytical Chemistry. 2020;873:114324. doi:10.1016/j.jelechem.2020.114324 .
Vajdle, Olga, Šekuljica, Sanja, Guzsvány, Valéria, Nagy, László, Kónya, Zoltán, Avramov-Ivić, Milka, Mijin, Dušan, Petrović, Slobodan, Anojčić, Jasmina, "Use of carbon paste electrode and modified by gold nanoparticles for selected macrolide antibiotics determination as standard and in pharmaceutical preparations" in Journal of Electroanalytical Chemistry, 873 (2020):114324, https://doi.org/10.1016/j.jelechem.2020.114324 . .