TechnoRep - Faculty of Technology and Metallurgy Repository
University of Belgrade - Faculty of Technology and Metallurgy
    • English
    • Српски
    • Српски (Serbia)
  • English 
    • English
    • Serbian (Cyrillic)
    • Serbian (Latin)
  • Login
View Item 
  •   TechnoRep
  • Tehnološko-metalurški fakultet
  • Radovi istraživača / Researchers’ publications (TMF)
  • View Item
  •   TechnoRep
  • Tehnološko-metalurški fakultet
  • Radovi istraživača / Researchers’ publications (TMF)
  • View Item
JavaScript is disabled for your browser. Some features of this site may not work without it.

Mechanical Oscillations in 2D Collective Cell Migration: The Elastic Turbulence

Thumbnail
2020
4445.pdf (1.454Mb)
Authors
Pajić-Lijaković, Ivana
Milivojević, Milan
Article (Published version)
Metadata
Show full item record
Abstract
Various types of mechanical waves, such as propagative waves and standing waves, are observed during 2D collective cell migration. Propagative waves are generated during monolayer free expansion, whereas standing waves are generated during swirling motion of a confluent monolayer. Significant attempts have been made to describe the main characteristics of mechanical waves obtained within various experimental systems. However, much less attention is paid to correlate the viscoelasticity with the generated oscillatory instabilities. Mechanical waves have recognized during flow of various viscoelastic systems under low Reynolds number and called "the elastic turbulence." In addition to Reynolds number, Weissenberg number is needed for characterizing the elastic turbulence. The viscoelastic resistive force generated during collective cell migration caused by a residual stress accumulation is capable of inducing apparent inertial effects by balancing with other forces such as the surface te...nsion force, the traction force, and the resultant force responsible for cell migration. The resultant force represents a product of various biochemical processes such as cell signaling and gene expression. The force balance induces (1) forward flow and backward flow in the direction of cell migration as characteristics of the propagative waves and (2) inflow and outflow perpendicular to the direction of migration as characteristics of the standing waves. The apparent inertial effects are essential for appearing the elastic turbulence and represent the characteristic of (1) the backward flow during the monolayer free expansion and (2) the inflow during the cell swirling motion within a confluent monolayer.

Keywords:
multi scale nature of viscoelasticity of multicellular system / collective cell migration / apparent inertia effects / the elastic turbulence / rheological behavior of extracellular matrix
Source:
Frontiers in Physics, 2020, 8
Publisher:
  • Frontiers Media Sa, Lausanne
Funding / projects:
  • Ministry of Education, Science and Technological Development, Republic of Serbia, Grant no. 200135 (University of Belgrade, Faculty of Technology and Metallurgy) (RS-200135)

DOI: 10.3389/fphy.2020.585681

ISSN: 2296-424X

WoS: 000591196100001

Scopus: 2-s2.0-85096402159
[ Google Scholar ]
13
4
URI
http://TechnoRep.tmf.bg.ac.rs/handle/123456789/4448
Collections
  • Radovi istraživača / Researchers’ publications (TMF)
Institution/Community
Tehnološko-metalurški fakultet
TY  - JOUR
AU  - Pajić-Lijaković, Ivana
AU  - Milivojević, Milan
PY  - 2020
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/4448
AB  - Various types of mechanical waves, such as propagative waves and standing waves, are observed during 2D collective cell migration. Propagative waves are generated during monolayer free expansion, whereas standing waves are generated during swirling motion of a confluent monolayer. Significant attempts have been made to describe the main characteristics of mechanical waves obtained within various experimental systems. However, much less attention is paid to correlate the viscoelasticity with the generated oscillatory instabilities. Mechanical waves have recognized during flow of various viscoelastic systems under low Reynolds number and called "the elastic turbulence." In addition to Reynolds number, Weissenberg number is needed for characterizing the elastic turbulence. The viscoelastic resistive force generated during collective cell migration caused by a residual stress accumulation is capable of inducing apparent inertial effects by balancing with other forces such as the surface tension force, the traction force, and the resultant force responsible for cell migration. The resultant force represents a product of various biochemical processes such as cell signaling and gene expression. The force balance induces (1) forward flow and backward flow in the direction of cell migration as characteristics of the propagative waves and (2) inflow and outflow perpendicular to the direction of migration as characteristics of the standing waves. The apparent inertial effects are essential for appearing the elastic turbulence and represent the characteristic of (1) the backward flow during the monolayer free expansion and (2) the inflow during the cell swirling motion within a confluent monolayer.
PB  - Frontiers Media Sa, Lausanne
T2  - Frontiers in Physics
T1  - Mechanical Oscillations in 2D Collective Cell Migration: The Elastic Turbulence
VL  - 8
DO  - 10.3389/fphy.2020.585681
ER  - 
@article{
author = "Pajić-Lijaković, Ivana and Milivojević, Milan",
year = "2020",
abstract = "Various types of mechanical waves, such as propagative waves and standing waves, are observed during 2D collective cell migration. Propagative waves are generated during monolayer free expansion, whereas standing waves are generated during swirling motion of a confluent monolayer. Significant attempts have been made to describe the main characteristics of mechanical waves obtained within various experimental systems. However, much less attention is paid to correlate the viscoelasticity with the generated oscillatory instabilities. Mechanical waves have recognized during flow of various viscoelastic systems under low Reynolds number and called "the elastic turbulence." In addition to Reynolds number, Weissenberg number is needed for characterizing the elastic turbulence. The viscoelastic resistive force generated during collective cell migration caused by a residual stress accumulation is capable of inducing apparent inertial effects by balancing with other forces such as the surface tension force, the traction force, and the resultant force responsible for cell migration. The resultant force represents a product of various biochemical processes such as cell signaling and gene expression. The force balance induces (1) forward flow and backward flow in the direction of cell migration as characteristics of the propagative waves and (2) inflow and outflow perpendicular to the direction of migration as characteristics of the standing waves. The apparent inertial effects are essential for appearing the elastic turbulence and represent the characteristic of (1) the backward flow during the monolayer free expansion and (2) the inflow during the cell swirling motion within a confluent monolayer.",
publisher = "Frontiers Media Sa, Lausanne",
journal = "Frontiers in Physics",
title = "Mechanical Oscillations in 2D Collective Cell Migration: The Elastic Turbulence",
volume = "8",
doi = "10.3389/fphy.2020.585681"
}
Pajić-Lijaković, I.,& Milivojević, M.. (2020). Mechanical Oscillations in 2D Collective Cell Migration: The Elastic Turbulence. in Frontiers in Physics
Frontiers Media Sa, Lausanne., 8.
https://doi.org/10.3389/fphy.2020.585681
Pajić-Lijaković I, Milivojević M. Mechanical Oscillations in 2D Collective Cell Migration: The Elastic Turbulence. in Frontiers in Physics. 2020;8.
doi:10.3389/fphy.2020.585681 .
Pajić-Lijaković, Ivana, Milivojević, Milan, "Mechanical Oscillations in 2D Collective Cell Migration: The Elastic Turbulence" in Frontiers in Physics, 8 (2020),
https://doi.org/10.3389/fphy.2020.585681 . .

DSpace software copyright © 2002-2015  DuraSpace
About TechnoRep | Send Feedback

OpenAIRERCUB
 

 

All of DSpaceInstitutions/communitiesAuthorsTitlesSubjectsThis institutionAuthorsTitlesSubjects

Statistics

View Usage Statistics

DSpace software copyright © 2002-2015  DuraSpace
About TechnoRep | Send Feedback

OpenAIRERCUB