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dc.creatorStojanović, Marija
dc.creatorSimović, Milica
dc.creatorMihailović, Mladen
dc.creatorVeličković, Dušan
dc.creatorDimitrijević, Aleksandra
dc.creatorMilosavić, Nenad
dc.creatorBezbradica, Dejan
dc.date.accessioned2021-03-15T11:58:04Z
dc.date.available2021-03-15T11:58:04Z
dc.date.issued2015
dc.identifier.issn0885-4513
dc.identifier.urihttp://TechnoRep.tmf.bg.ac.rs/handle/123456789/4720
dc.description.abstractFatty acid (FA) ascorbyl esters are recently emerging food, cosmetic, and pharmaceutical additives, which can be prepared in an eco-friendly way by using lipases as catalysts. Because they are amphiphilic molecules, which possess high free radical scavenging capacity, they can be applied as liposoluble antioxidants as well as emulsifiers and biosurfactants. In this study, the influence of a wide range of acyl donors on ester yield in lipase-catalyzed synthesis and ester antioxidant activity was examined. Among saturated acyl donors, higher yields and antioxidant activities of esters were achieved when short-chain FAs were used. Oleic acid gave the highest yield overall and its ester exhibited a high antioxidant activity. Optimization of experimental factors showed that the highest conversion (60.5%) in acetone was achieved with 5 g L-1 of lipase, 50 mM of vitamin C, 10-fold molar excess of oleic acid, and 0.7 mL L-1 of initial water. Obtained results showed that even short- and medium-chain ascorbyl esters could be synthesized with high yields and retained (or even exceeded) free radical scavenging capacity of l-ascorbic acid, indicating prospects of broadening their application in emulsions and liposomes.
dc.languageen
dc.publisherWiley, Hoboken
dc.relationinfo:eu-repo/grantAgreement/MESTD/Integrated and Interdisciplinary Research (IIR or III)/46010/RS//
dc.rightsembargoedAccess
dc.rights.urihttps://creativecommons.org/licenses/by-nc/4.0/
dc.sourceBiotechnology and Applied Biochemistry
dc.titleInfluence of fatty acid on lipase-catalyzed synthesis of ascorbyl esters and their free radical scavenging capacity
dc.typearticleen
dc.rights.licenseBY-NC
dc.citation.epage466
dc.citation.issue4
dc.citation.rankM23
dc.citation.spage458
dc.citation.volume62
dc.description.otherThis is the peer-reviewed version of the following article: Stojanović, M.; Simović, M.; Mihailović, M.; Veličković, D.; Dimitrijević, A.; Milosavić, N.; Bezbradica, D. Influence of Fatty Acid on Lipase-Catalyzed Synthesis of Ascorbyl Esters and Their Free Radical Scavenging Capacity. Biotechnology and Applied Biochemistry 2015, 62 (4), 458–466. [https://doi.org/10.1002/bab.1296]
dc.identifier.doi10.1002/bab.1296
dc.identifier.fulltexthttp://TechnoRep.tmf.bg.ac.rs/bitstream/id/7269/Influence_of_fatty_acc_2015.pdf
dc.identifier.scopus2-s2.0-84939574136
dc.identifier.wos000360229200004
dc.type.versionacceptedVersion


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