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dc.creatorJovanović, Aleksandra
dc.creatorLevic, Steva M.
dc.creatorPavlović, Vladimir B.
dc.creatorMarkovic, Smilja B.
dc.creatorPjanović, Rada
dc.creatorĐorđević, Verica
dc.creatorNedović, Viktor
dc.creatorBugarski, Branko
dc.date.accessioned2022-03-04T11:20:43Z
dc.date.available2022-03-04T11:20:43Z
dc.date.issued2021
dc.identifier.issn1420-3049
dc.identifier.urihttp://TechnoRep.tmf.bg.ac.rs/handle/123456789/4863
dc.description.abstractFreeze drying was compared with spray drying regarding feasibility to process wild thyme drugs in order to obtain dry formulations at laboratory scale starting from liquid extracts produced by different extraction methods: maceration and heat-, ultrasound-, and microwave-assisted extractions. Higher total powder yield (based on the dry weight prior to extraction) was achieved by freeze than spray drying and lower loss of total polyphenol content (TPC) and total flavonoid content (TFC) due to the drying process. Gelatin as a coating agent (5% w/w) provided better TPC recovery by 70% in case of lyophilization and higher total powder yield in case of spray drying by diminishing material deposition on the wall of the drying chamber. The resulting gelatin-free and gelatin-containing powders carried polyphenols in amount similar to 190 and 53-75 mg gallic acid equivalents GAE/g of powder, respectively. Microwave-assisted extract formulation was distinguished from the others by a higher content of polyphenols, proteins and sugars, higher bulk density and lower solubility. The type of the drying process mainly affected the position of the gelatin-derived -OH and amide bands in FTIR spectra. Spray-dried formulations compared to freeze-dried expressed higher thermal stability as confirmed by differential scanning calorimetry analysis and a higher diffusion coefficient; the last feature can be associated with the lower specific surface area of irregularly shaped freeze-dried particles (151-223 mu m) compared to small microspheres (similar to 8 mu m) in spray-dried powder.en
dc.relationinfo:eu-repo/grantAgreement/MESTD/inst-2020/200003/RS//
dc.relationinfo:eu-repo/grantAgreement/MESTD/inst-2020/200135/RS//
dc.relationinfo:eu-repo/grantAgreement/MESTD/inst-2020/200287/RS//
dc.rightsopenAccess
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.sourceMolecules
dc.subjectencapsulationen
dc.subjectfreeze dryingen
dc.subjectgelatinen
dc.subjectpolyphenolsen
dc.subjectspray dryingen
dc.titleFreeze vs. Spray Drying for Dry Wild Thyme (Thymus serpyllum L.) Extract Formulations: The Impact of Gelatin as a Coating Materialen
dc.typearticle
dc.rights.licenseBY
dc.citation.issue13
dc.citation.other26(13): -
dc.citation.rankM22
dc.citation.volume26
dc.identifier.doi10.3390/molecules26133933
dc.identifier.fulltexthttp://TechnoRep.tmf.bg.ac.rs/bitstream/id/7947/Freeze_vs._Spray_pub_2021.pdf
dc.identifier.pmid34203164
dc.identifier.scopus2-s2.0-85109563316
dc.identifier.wos000672012700001
dc.type.versionpublishedVersion


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Приказ основних података о документу