Novel Hydrogel Scaffolds Based on Alginate, Gelatin, 2-Hydroxyethyl Methacrylate, and Hydroxyapatite
Authors
Tomić, SimonidaNikodinović-Runić, Jasmina
Vukomanovic, Marija
Babić, Marija M.
Vuković, Jovana
Article (Published version)
Metadata
Show full item recordAbstract
Hydrogel scaffolding biomaterials are one of the most attractive polymeric biomaterials for regenerative engineering and can be engineered into tissue mimetic scaffolds to support cell growth due to their similarity to the native extracellular matrix. The novel, versatile hydrogel scaffolds based on alginate, gelatin, 2-hydroxyethyl methacrylate, and inorganic agent hydroxyapatite were prepared by modified cryogelation. The chemical composition, morphology, porosity, mechanical properties, effects on cell viability, in vitro degradation, in vitro and in vivo biocompatibility were tested to correlate the material's composition with the corresponding properties. Scaffolds showed an interconnected porous microstructure, satisfactory mechanical strength, favorable hydrophilicity, degradation, and suitable in vitro and in vivo biocompatible behavior. Materials showed good biocompatibility with healthy human fibroblast in cell culture, as well as in vivo with zebrafish assay, suggesting newl...y synthesized hydrogel scaffolds as a potential new generation of hydrogel scaffolding biomaterials with tunable properties for versatile biomedical applications and tissue regeneration.
Keywords:
alginate / gelatin / 2-hydroxyethyl methacrylate / hydroxyapatite / hydrogel scaffolding biomaterial / degradable scaffolds / biocompatibility / tissue regeneration engineeringSource:
Polymers, 2021, 13, 6, 932-Funding / projects:
- Chemical and structural designing of nanomaterials for application in medicine and tissue engineering (RS-MESTD-Basic Research (BR or ON)-172026)
- Synthesis and characterization of novel functional polymers and polymeric nanocomposites (RS-MESTD-Basic Research (BR or ON)-172062)
DOI: 10.3390/polym13060932
ISSN: 2073-4360
PubMed: 33803545
WoS: 000651944700001
Scopus: 2-s2.0-85103494235
Institution/Community
Tehnološko-metalurški fakultetTY - JOUR AU - Tomić, Simonida AU - Nikodinović-Runić, Jasmina AU - Vukomanovic, Marija AU - Babić, Marija M. AU - Vuković, Jovana PY - 2021 UR - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/4926 AB - Hydrogel scaffolding biomaterials are one of the most attractive polymeric biomaterials for regenerative engineering and can be engineered into tissue mimetic scaffolds to support cell growth due to their similarity to the native extracellular matrix. The novel, versatile hydrogel scaffolds based on alginate, gelatin, 2-hydroxyethyl methacrylate, and inorganic agent hydroxyapatite were prepared by modified cryogelation. The chemical composition, morphology, porosity, mechanical properties, effects on cell viability, in vitro degradation, in vitro and in vivo biocompatibility were tested to correlate the material's composition with the corresponding properties. Scaffolds showed an interconnected porous microstructure, satisfactory mechanical strength, favorable hydrophilicity, degradation, and suitable in vitro and in vivo biocompatible behavior. Materials showed good biocompatibility with healthy human fibroblast in cell culture, as well as in vivo with zebrafish assay, suggesting newly synthesized hydrogel scaffolds as a potential new generation of hydrogel scaffolding biomaterials with tunable properties for versatile biomedical applications and tissue regeneration. T2 - Polymers T1 - Novel Hydrogel Scaffolds Based on Alginate, Gelatin, 2-Hydroxyethyl Methacrylate, and Hydroxyapatite IS - 6 SP - 932 VL - 13 DO - 10.3390/polym13060932 ER -
@article{ author = "Tomić, Simonida and Nikodinović-Runić, Jasmina and Vukomanovic, Marija and Babić, Marija M. and Vuković, Jovana", year = "2021", abstract = "Hydrogel scaffolding biomaterials are one of the most attractive polymeric biomaterials for regenerative engineering and can be engineered into tissue mimetic scaffolds to support cell growth due to their similarity to the native extracellular matrix. The novel, versatile hydrogel scaffolds based on alginate, gelatin, 2-hydroxyethyl methacrylate, and inorganic agent hydroxyapatite were prepared by modified cryogelation. The chemical composition, morphology, porosity, mechanical properties, effects on cell viability, in vitro degradation, in vitro and in vivo biocompatibility were tested to correlate the material's composition with the corresponding properties. Scaffolds showed an interconnected porous microstructure, satisfactory mechanical strength, favorable hydrophilicity, degradation, and suitable in vitro and in vivo biocompatible behavior. Materials showed good biocompatibility with healthy human fibroblast in cell culture, as well as in vivo with zebrafish assay, suggesting newly synthesized hydrogel scaffolds as a potential new generation of hydrogel scaffolding biomaterials with tunable properties for versatile biomedical applications and tissue regeneration.", journal = "Polymers", title = "Novel Hydrogel Scaffolds Based on Alginate, Gelatin, 2-Hydroxyethyl Methacrylate, and Hydroxyapatite", number = "6", pages = "932", volume = "13", doi = "10.3390/polym13060932" }
Tomić, S., Nikodinović-Runić, J., Vukomanovic, M., Babić, M. M.,& Vuković, J.. (2021). Novel Hydrogel Scaffolds Based on Alginate, Gelatin, 2-Hydroxyethyl Methacrylate, and Hydroxyapatite. in Polymers, 13(6), 932. https://doi.org/10.3390/polym13060932
Tomić S, Nikodinović-Runić J, Vukomanovic M, Babić MM, Vuković J. Novel Hydrogel Scaffolds Based on Alginate, Gelatin, 2-Hydroxyethyl Methacrylate, and Hydroxyapatite. in Polymers. 2021;13(6):932. doi:10.3390/polym13060932 .
Tomić, Simonida, Nikodinović-Runić, Jasmina, Vukomanovic, Marija, Babić, Marija M., Vuković, Jovana, "Novel Hydrogel Scaffolds Based on Alginate, Gelatin, 2-Hydroxyethyl Methacrylate, and Hydroxyapatite" in Polymers, 13, no. 6 (2021):932, https://doi.org/10.3390/polym13060932 . .